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• W4200508970 abstract "Vinca alkaloids are well-known microtubule targeting agents, which are used against some types of cancer. Vindoline is one of the monomeric Vinca alkaloids which does not have anti-tumor effect, although its derivatives have serious impact on the field of these indole alkaloids. Chrysin is a secondary plant metabolite, which has broad-spectrum biological activity, among others anticancer activity. Chrysin had shown synergic effect with several antiproliferative compounds (e. g., doxorubicin, cisplatin and ciglitazone), therefore, we attempted the synthesis of a novel vindoline-chrysin hybrid molecule. However, in the first case a diphenylamine structure was isolated. The mechanism of the unexpected reaction was studied, and then the originally targeted hybrid was synthesized by a reverse route coupling. A further hybrid was produced using a different site of the molecule. The antitumor activities were determined against 60 human tumor cell lines (NCI60), where the aimed hybrid showed low micromolar GI50 values on most of the cell lines." @default.
• W4200508970 created "2021-12-31" @default.
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• W4200508970 date "2021-12-07" @default.
• W4200508970 modified "2023-09-26" @default.
• W4200508970 title "Synthesis of Novel Vindoline‐Chrysin Hybrids" @default.
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• W4200508970 doi "https://doi.org/10.1002/cbdv.202100725" @default.
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