FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200509322> ?p ?o ?g. }

• W4200509322 abstract "The applications of deep sequencing technologies in life science research and clinical diagnostics have increased rapidly over the last decade. Although fast algorithms for data processing exist, intuitive, portable solutions for data analysis are still rare. For this purpose, we developed a web-based transcriptome data-base, which provides a platform-independent, intuitive solution to easily explore and compare ocular gene expression of 100 diseased and healthy human tissue samples from 15 different tissue types collected at the Eye Center of the Universi-ty of Freiburg. To ensure comparability of expression between different tissues, reads were normalized across all 100 samples. Differentially expressed genes were calculated between each tissue type to determine tissue-specific genes. Unsupervised analysis of all 100 samples revealed an accurate clustering ac-cording to different tissue types. Cluster analysis based on known cell type-specific marker genes allowed differentiation of respective tissues. Several tis-sue-specific marker genes were identified. These genes were involved in tissue- or disease-specific processes, such as myelination for the optic nerve, visual perception for retina, keratinocyte differentiation for conjunctival carcinoma, as well as endothelial cell migration for choroidal neovascularization membranes. The results are accessible at the Human Eye Transcriptome Atlas website at https://www.eye-transcriptome.com. In summary, this searchable transcriptome database enables easy exploration of ocular gene expression in healthy and diseased human ocular tissues without bioinformatics expertise. Thus, it provides rapid access to detailed insights into the molecular mechanisms of various ocular tissues and diseases, as well as the rapid retrieval of potential new diagnostic and therapeutic targets." @default.
• W4200509322 created "2021-12-31" @default.
• W4200509322 creator A5008216236 @default.
• W4200509322 creator A5025141761 @default.
• W4200509322 creator A5031077655 @default.
• W4200509322 creator A5035282612 @default.
• W4200509322 creator A5048384772 @default.
• W4200509322 creator A5056699097 @default.
• W4200509322 creator A5058057229 @default.
• W4200509322 creator A5061950047 @default.
• W4200509322 creator A5066426166 @default.
• W4200509322 creator A5078246476 @default.
• W4200509322 date "2021-11-05" @default.
• W4200509322 modified "2023-10-15" @default.
• W4200509322 title "The Human Eye Transcriptome Atlas: A Searchable Comparative Transcriptome Database for Healthy and Diseased Human Eye Tissue" @default.
• W4200509322 doi "https://doi.org/10.1101/2021.11.04.467318" @default.
• W4200509322 hasPublicationYear "2021" @default.
• W4200509322 type Work @default.
• W4200509322 citedByCount "1" @default.
• W4200509322 countsByYear W42005093222021 @default.
• W4200509322 crossrefType "posted-content" @default.
• W4200509322 hasAuthorship W4200509322A5008216236 @default.
• W4200509322 hasAuthorship W4200509322A5025141761 @default.
• W4200509322 hasAuthorship W4200509322A5031077655 @default.
• W4200509322 hasAuthorship W4200509322A5035282612 @default.
• W4200509322 hasAuthorship W4200509322A5048384772 @default.
• W4200509322 hasAuthorship W4200509322A5056699097 @default.
• W4200509322 hasAuthorship W4200509322A5058057229 @default.
• W4200509322 hasAuthorship W4200509322A5061950047 @default.
• W4200509322 hasAuthorship W4200509322A5066426166 @default.
• W4200509322 hasAuthorship W4200509322A5078246476 @default.
• W4200509322 hasBestOaLocation W42005093221 @default.
• W4200509322 hasConcept C104317684 @default.
• W4200509322 hasConcept C150194340 @default.
• W4200509322 hasConcept C162317418 @default.
• W4200509322 hasConcept C54355233 @default.
• W4200509322 hasConcept C70721500 @default.
• W4200509322 hasConcept C86803240 @default.
• W4200509322 hasConceptScore W4200509322C104317684 @default.
• W4200509322 hasConceptScore W4200509322C150194340 @default.
• W4200509322 hasConceptScore W4200509322C162317418 @default.
• W4200509322 hasConceptScore W4200509322C54355233 @default.
• W4200509322 hasConceptScore W4200509322C70721500 @default.
• W4200509322 hasConceptScore W4200509322C86803240 @default.
• W4200509322 hasLocation W42005093221 @default.
• W4200509322 hasOpenAccess W4200509322 @default.
• W4200509322 hasPrimaryLocation W42005093221 @default.
• W4200509322 hasRelatedWork W1971124177 @default.
• W4200509322 hasRelatedWork W2009966535 @default.
• W4200509322 hasRelatedWork W2102579905 @default.
• W4200509322 hasRelatedWork W2734403094 @default.
• W4200509322 hasRelatedWork W3012091774 @default.
• W4200509322 hasRelatedWork W3097825150 @default.
• W4200509322 hasRelatedWork W3146618441 @default.
• W4200509322 hasRelatedWork W3201422854 @default.
• W4200509322 hasRelatedWork W4220661273 @default.
• W4200509322 hasRelatedWork W4247273247 @default.
• W4200509322 isParatext "false" @default.
• W4200509322 isRetracted "false" @default.
• W4200509322 workType "article" @default.