FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200509527> ?p ?o ?g. }

• W4200509527 endingPage "108411" @default.
• W4200509527 startingPage "108411" @default.
• W4200509527 abstract "Healthy aging may be associated with neural degeneration in the cochlea even before clinical hearing loss emerges. Reduction in frequency-following responses (FFRs) to tonal carriers in older clinically normal-hearing listeners has previously been reported, and has been argued to reflect an age-dependent decline in temporal processing in the central auditory system. Alternatively, age-dependent loss of auditory nerve fibers (ANFs) may have little effect on audiometric sensitivity and yet compromise the precision of neural phase-locking relying on joint activity across populations of fibers. This peripheral loss may, in turn, contribute to reduced neural synchrony in the brainstem as reflected in the FFR. Here, we combined human electrophysiology and auditory nerve (AN) modeling to investigate whether age-related changes in the FFR would be consistent with peripheral neural degeneration. FFRs elicited by pure tones and frequency sweeps at carrier frequencies between 200 and 1200 Hz were obtained in older (ages 48-76) and younger (ages 20-30) listeners, both groups having clinically normal audiometric thresholds up to 6 kHz. The same stimuli were presented to a computational model of the AN in which age-related loss of hair cells or ANFs was modelled using human histopathological data. In the older human listeners, the measured FFRs to both sweeps and pure tones were found to be reduced across the carrier frequencies examined. These FFR reductions were consistent with model simulations of age-related ANF loss. In model simulations, the phase-locked response produced by the population of remaining fibers decreased proportionally with increasing loss of the ANFs. Basal-turn loss of inner hair cells also reduced synchronous activity at lower frequencies, albeit to a lesser degree. Model simulations of age-related threshold elevation further indicated that outer hair cell dysfunction had no negative effect on phase-locked AN responses. These results are consistent with a peripheral source of the FFR reductions observed in older normal-hearing listeners, and indicate that FFRs at lower carrier frequencies may potentially be a sensitive marker of peripheral neural degeneration." @default.
• W4200509527 created "2021-12-31" @default.
• W4200509527 creator A5011347693 @default.
• W4200509527 creator A5035701879 @default.
• W4200509527 creator A5046255570 @default.
• W4200509527 creator A5056775688 @default.
• W4200509527 creator A5072612624 @default.
• W4200509527 creator A5078013894 @default.
• W4200509527 date "2022-02-01" @default.
• W4200509527 modified "2023-09-26" @default.
• W4200509527 title "Age-related reduction in frequency-following responses as a potential marker of cochlear neural degeneration" @default.
• W4200509527 cites W1497444511 @default.
• W4200509527 cites W1511507145 @default.
• W4200509527 cites W1529222614 @default.
• W4200509527 cites W1543088917 @default.
• W4200509527 cites W1881872627 @default.
• W4200509527 cites W1967037344 @default.
• W4200509527 cites W1972168487 @default.
• W4200509527 cites W1979556977 @default.
• W4200509527 cites W1980778624 @default.
• W4200509527 cites W1983171295 @default.
• W4200509527 cites W1993569028 @default.
• W4200509527 cites W1995452115 @default.
• W4200509527 cites W1996233236 @default.
• W4200509527 cites W2003046807 @default.
• W4200509527 cites W2006378264 @default.
• W4200509527 cites W2006571108 @default.
• W4200509527 cites W2010019352 @default.
• W4200509527 cites W2015132422 @default.
• W4200509527 cites W2023565615 @default.
• W4200509527 cites W2024442432 @default.
• W4200509527 cites W2027321916 @default.
• W4200509527 cites W2030431480 @default.
• W4200509527 cites W2033268692 @default.
• W4200509527 cites W2035840980 @default.
• W4200509527 cites W2037115848 @default.
• W4200509527 cites W2037918173 @default.
• W4200509527 cites W2043956553 @default.
• W4200509527 cites W2045745277 @default.
• W4200509527 cites W2051642304 @default.
• W4200509527 cites W2053365926 @default.
• W4200509527 cites W2057336857 @default.
• W4200509527 cites W2057725339 @default.
• W4200509527 cites W2059070069 @default.
• W4200509527 cites W2060102462 @default.
• W4200509527 cites W2061759362 @default.
• W4200509527 cites W2064036565 @default.
• W4200509527 cites W2064743338 @default.
• W4200509527 cites W2066557022 @default.
• W4200509527 cites W2066828931 @default.
• W4200509527 cites W2075295076 @default.
• W4200509527 cites W2089402280 @default.
• W4200509527 cites W2091739746 @default.
• W4200509527 cites W2092663121 @default.
• W4200509527 cites W2097498366 @default.
• W4200509527 cites W2114143668 @default.
• W4200509527 cites W2114226942 @default.
• W4200509527 cites W2127399017 @default.
• W4200509527 cites W2151886218 @default.
• W4200509527 cites W2161851299 @default.
• W4200509527 cites W2171061694 @default.
• W4200509527 cites W2182271310 @default.
• W4200509527 cites W2186445644 @default.
• W4200509527 cites W2189352412 @default.
• W4200509527 cites W222028059 @default.
• W4200509527 cites W2269259465 @default.
• W4200509527 cites W2279581188 @default.
• W4200509527 cites W2315870034 @default.
• W4200509527 cites W2336568988 @default.
• W4200509527 cites W2444494065 @default.
• W4200509527 cites W2508567103 @default.
• W4200509527 cites W2510415332 @default.
• W4200509527 cites W2520380456 @default.
• W4200509527 cites W2548290184 @default.
• W4200509527 cites W2650156602 @default.
• W4200509527 cites W2765384211 @default.
• W4200509527 cites W2767572399 @default.
• W4200509527 cites W2777667864 @default.
• W4200509527 cites W2781404744 @default.
• W4200509527 cites W2795174957 @default.
• W4200509527 cites W2879916001 @default.
• W4200509527 cites W2884288133 @default.
• W4200509527 cites W2886113798 @default.
• W4200509527 cites W2898242559 @default.
• W4200509527 cites W2921978574 @default.
• W4200509527 cites W2941449643 @default.
• W4200509527 cites W2950629677 @default.
• W4200509527 cites W2954092764 @default.
• W4200509527 cites W2987410081 @default.
• W4200509527 cites W3042659524 @default.
• W4200509527 cites W3107091102 @default.
• W4200509527 cites W3138669734 @default.
• W4200509527 cites W3212669898 @default.
• W4200509527 doi "https://doi.org/10.1016/j.heares.2021.108411" @default.
• W4200509527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34929535" @default.
• W4200509527 hasPublicationYear "2022" @default.
• W4200509527 type Work @default.
• W4200509527 citedByCount "3" @default.

• next