FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200511349> ?p ?o ?g. }

• W4200511349 abstract "Interferon-gamma (IFN-γ) is overexpressed in rheumatoid synovium and thought to be involved in the pathogenesis of rheumatoid arthritis (RA). In this study, we examined our hypothesis that IFN-γ activates innate immune cells and upregulates inflammatory cytokines. Peripheral blood neutrophils were stimulated with IFN-γ in the presence or absence of Janus kinase (JAK) inhibitors. Interleukin-6 (IL-6) mRNA and protein expression were analyzed using real-time polymerase chain reaction (PCR) method and enzyme-linked immunosorbent assay. Protein phosphorylation of JAKs or STAT1 was assessed by Western blot using phospho-specific antibodies.IFN-γ stimulation induces IL-6 expression in protein and mRNA levels in human neutrophils. Furthermore, IFN-γ stimulation induces JAK1/JAK2 phosphorylation and downstream signal transducer and activator of transcription (STAT) 1 phosphorylation in human neutrophils. Although all JAKi, blocked IFN-γ-induced JAK1.2/STAT1 phosphorylation at higher concentrations (100 nM), baricitinib most efficiently inhibited IFN-γ-induced JAK1.2/STAT1 phosphorylation at lower concentrations (≤ 25 nM). Among these JAKi, baricitinib was the most potent regulator for IFN-γ-induced IL-6 production in human neutrophils. Our data indicate that IFN-γ upregulates IL-6 production via the JAK1/2-STAT1 pathway in human innate immune cells. Furthermore, this IFN-γ-mediated IL-6 induction via JAK/STAT was downregulated by JAKi." @default.
• W4200511349 created "2021-12-31" @default.
• W4200511349 creator A5010988080 @default.
• W4200511349 creator A5013815950 @default.
• W4200511349 creator A5017736424 @default.
• W4200511349 creator A5038413661 @default.
• W4200511349 creator A5040468145 @default.
• W4200511349 creator A5044267497 @default.
• W4200511349 creator A5057574490 @default.
• W4200511349 creator A5059480693 @default.
• W4200511349 creator A5071346122 @default.
• W4200511349 creator A5075159797 @default.
• W4200511349 creator A5079822291 @default.
• W4200511349 creator A5088939006 @default.
• W4200511349 date "2021-12-01" @default.
• W4200511349 modified "2023-10-07" @default.
• W4200511349 title "Interferon-γ induces interleukin-6 production by neutrophils via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway" @default.
• W4200511349 cites W1559833512 @default.
• W4200511349 cites W1953573634 @default.
• W4200511349 cites W1965366240 @default.
• W4200511349 cites W1976133234 @default.
• W4200511349 cites W1994367842 @default.
• W4200511349 cites W2001294602 @default.
• W4200511349 cites W2031060692 @default.
• W4200511349 cites W2054883607 @default.
• W4200511349 cites W2069520063 @default.
• W4200511349 cites W2098776090 @default.
• W4200511349 cites W2112855876 @default.
• W4200511349 cites W2133982451 @default.
• W4200511349 cites W2135718475 @default.
• W4200511349 cites W2137368119 @default.
• W4200511349 cites W2152985701 @default.
• W4200511349 cites W2155702314 @default.
• W4200511349 cites W2171197664 @default.
• W4200511349 cites W2239571459 @default.
• W4200511349 cites W2257779930 @default.
• W4200511349 cites W2276265958 @default.
• W4200511349 cites W2623617647 @default.
• W4200511349 cites W2808860595 @default.
• W4200511349 cites W2884938031 @default.
• W4200511349 cites W2954359924 @default.
• W4200511349 cites W2991331878 @default.
• W4200511349 cites W3009820091 @default.
• W4200511349 cites W3018387634 @default.
• W4200511349 cites W3207808840 @default.
• W4200511349 doi "https://doi.org/10.1186/s13104-021-05860-w" @default.
• W4200511349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34895310" @default.
• W4200511349 hasPublicationYear "2021" @default.
• W4200511349 type Work @default.
• W4200511349 citedByCount "5" @default.
• W4200511349 countsByYear W42005113492022 @default.
• W4200511349 countsByYear W42005113492023 @default.
• W4200511349 crossrefType "journal-article" @default.
• W4200511349 hasAuthorship W4200511349A5010988080 @default.
• W4200511349 hasAuthorship W4200511349A5013815950 @default.
• W4200511349 hasAuthorship W4200511349A5017736424 @default.
• W4200511349 hasAuthorship W4200511349A5038413661 @default.
• W4200511349 hasAuthorship W4200511349A5040468145 @default.
• W4200511349 hasAuthorship W4200511349A5044267497 @default.
• W4200511349 hasAuthorship W4200511349A5057574490 @default.
• W4200511349 hasAuthorship W4200511349A5059480693 @default.
• W4200511349 hasAuthorship W4200511349A5071346122 @default.
• W4200511349 hasAuthorship W4200511349A5075159797 @default.
• W4200511349 hasAuthorship W4200511349A5079822291 @default.
• W4200511349 hasAuthorship W4200511349A5088939006 @default.
• W4200511349 hasBestOaLocation W42005113491 @default.
• W4200511349 hasConcept C101544691 @default.
• W4200511349 hasConcept C112392421 @default.
• W4200511349 hasConcept C11960822 @default.
• W4200511349 hasConcept C136449434 @default.
• W4200511349 hasConcept C153911025 @default.
• W4200511349 hasConcept C154390347 @default.
• W4200511349 hasConcept C157333092 @default.
• W4200511349 hasConcept C171958077 @default.
• W4200511349 hasConcept C183315844 @default.
• W4200511349 hasConcept C203014093 @default.
• W4200511349 hasConcept C2776090121 @default.
• W4200511349 hasConcept C2776178377 @default.
• W4200511349 hasConcept C2777003663 @default.
• W4200511349 hasConcept C2778277574 @default.
• W4200511349 hasConcept C2778690821 @default.
• W4200511349 hasConcept C2778923194 @default.
• W4200511349 hasConcept C2780841837 @default.
• W4200511349 hasConcept C32465701 @default.
• W4200511349 hasConcept C502942594 @default.
• W4200511349 hasConcept C62478195 @default.
• W4200511349 hasConcept C65439459 @default.
• W4200511349 hasConcept C79484868 @default.
• W4200511349 hasConcept C86803240 @default.
• W4200511349 hasConcept C8891405 @default.
• W4200511349 hasConcept C95444343 @default.
• W4200511349 hasConceptScore W4200511349C101544691 @default.
• W4200511349 hasConceptScore W4200511349C112392421 @default.
• W4200511349 hasConceptScore W4200511349C11960822 @default.
• W4200511349 hasConceptScore W4200511349C136449434 @default.
• W4200511349 hasConceptScore W4200511349C153911025 @default.
• W4200511349 hasConceptScore W4200511349C154390347 @default.
• W4200511349 hasConceptScore W4200511349C157333092 @default.
• W4200511349 hasConceptScore W4200511349C171958077 @default.
• W4200511349 hasConceptScore W4200511349C183315844 @default.

• next