FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200517711> ?p ?o ?g. }

• W4200517711 abstract "IL-22 plays a crucial role in promoting inflammation, antimicrobial immunity and tissue repair at barrier surfaces. The role of IL-22 in colitis is still controversial: while IL-22 has a protective effect on gut epithelium in acute injuries, it also enhances colitis in a context-dependent manner. Here, we summarize the Yin and Yang of IL-22 in colitis. Particularly, we emphasize the role of innate lymphoid cells (ILCs) in IL-22 production and regulation. A previously underappreciated transcription factor, Musculin (MSC), has been recently identified to be expressed in not only Th17 cells, but also RORγt+/Id2+ IL-22-producing group 3 ILCs in the gut of naïve mice. We hypothesize that the co-expression and interaction of MSC with the key transcription repressor Id2 in developing lymphoid cells (e.g., in LTi cells) and ILC precursors might fine tune the developmental programs or regulate the plasticity of adaptive Th subset and innate ILCs. The much-elevated expression of IL-22 in MSC-/- ILC3s suggests that MSC may function as: 1) a transcription suppressor for cytokines, particularly for IL-22, and/or 2) a gatekeeper for specific lineages of Th cells and innate ILCs as well. Amelioration of colitis symptoms in MSC-/- mice by IL-22-blocking agent IL-22BP-Fc suggests a counterintuitive pathogenic role of IL-22 in the absence of MSC as a checkpoint. The theory that exuberant production of IL-22 under pathological conditions (e.g., in human inflammatory bowel disease, IBD) may cause epithelial inflammation due to endoplasmic reticulum (ER) stress response is worth further investigation. Rheostatic regulation of IL-22 may be of therapeutic value to restore homeostatic balance and promote intestinal health in human colitis." @default.
• W4200517711 created "2021-12-31" @default.
• W4200517711 creator A5018484566 @default.
• W4200517711 creator A5020286464 @default.
• W4200517711 creator A5025154426 @default.
• W4200517711 creator A5051080513 @default.
• W4200517711 creator A5057638932 @default.
• W4200517711 creator A5062051935 @default.
• W4200517711 date "2021-12-21" @default.
• W4200517711 modified "2023-10-02" @default.
• W4200517711 title "The Pathogenic Roles of IL-22 in Colitis: Its Transcription Regulation by Musculin in T Helper Subsets and Innate Lymphoid Cells" @default.
• W4200517711 cites W1228965893 @default.
• W4200517711 cites W1579102917 @default.
• W4200517711 cites W1579108180 @default.
• W4200517711 cites W1580316172 @default.
• W4200517711 cites W1651776210 @default.
• W4200517711 cites W168918095 @default.
• W4200517711 cites W1891705702 @default.
• W4200517711 cites W1938903801 @default.
• W4200517711 cites W1971329821 @default.
• W4200517711 cites W1976026025 @default.
• W4200517711 cites W1979408872 @default.
• W4200517711 cites W1982180094 @default.
• W4200517711 cites W1985732675 @default.
• W4200517711 cites W1993460388 @default.
• W4200517711 cites W1995961172 @default.
• W4200517711 cites W2000246281 @default.
• W4200517711 cites W2002987322 @default.
• W4200517711 cites W2006338438 @default.
• W4200517711 cites W2006538571 @default.
• W4200517711 cites W2007136776 @default.
• W4200517711 cites W2008202534 @default.
• W4200517711 cites W2008713912 @default.
• W4200517711 cites W2008751364 @default.
• W4200517711 cites W2011882192 @default.
• W4200517711 cites W2016872451 @default.
• W4200517711 cites W2021340905 @default.
• W4200517711 cites W2034965950 @default.
• W4200517711 cites W2037259928 @default.
• W4200517711 cites W2047089179 @default.
• W4200517711 cites W2051465794 @default.
• W4200517711 cites W2054865038 @default.
• W4200517711 cites W2055912677 @default.
• W4200517711 cites W2058520337 @default.
• W4200517711 cites W2059402104 @default.
• W4200517711 cites W2069618168 @default.
• W4200517711 cites W2071377034 @default.
• W4200517711 cites W2080152737 @default.
• W4200517711 cites W2082898864 @default.
• W4200517711 cites W2083610532 @default.
• W4200517711 cites W2085625330 @default.
• W4200517711 cites W2086068975 @default.
• W4200517711 cites W2087549177 @default.
• W4200517711 cites W2091674262 @default.
• W4200517711 cites W2094624212 @default.
• W4200517711 cites W2097849141 @default.
• W4200517711 cites W2099220251 @default.
• W4200517711 cites W2101068992 @default.
• W4200517711 cites W2106464597 @default.
• W4200517711 cites W2107066107 @default.
• W4200517711 cites W2107401866 @default.
• W4200517711 cites W2119532085 @default.
• W4200517711 cites W2122084527 @default.
• W4200517711 cites W2122939321 @default.
• W4200517711 cites W2123462731 @default.
• W4200517711 cites W2123617326 @default.
• W4200517711 cites W2125742175 @default.
• W4200517711 cites W2126759065 @default.
• W4200517711 cites W2132130088 @default.
• W4200517711 cites W2146288152 @default.
• W4200517711 cites W2150892663 @default.
• W4200517711 cites W2152882892 @default.
• W4200517711 cites W2155272318 @default.
• W4200517711 cites W2155779547 @default.
• W4200517711 cites W2155997615 @default.
• W4200517711 cites W2160966000 @default.
• W4200517711 cites W2162442785 @default.
• W4200517711 cites W2164665293 @default.
• W4200517711 cites W2169355315 @default.
• W4200517711 cites W2170602248 @default.
• W4200517711 cites W2180956994 @default.
• W4200517711 cites W2195777839 @default.
• W4200517711 cites W2236648876 @default.
• W4200517711 cites W2243046831 @default.
• W4200517711 cites W2267931422 @default.
• W4200517711 cites W2283396335 @default.
• W4200517711 cites W2284327277 @default.
• W4200517711 cites W2327236643 @default.
• W4200517711 cites W2467696249 @default.
• W4200517711 cites W2493588600 @default.
• W4200517711 cites W2524037376 @default.
• W4200517711 cites W2530089097 @default.
• W4200517711 cites W2533422282 @default.
• W4200517711 cites W2581075228 @default.
• W4200517711 cites W2587770185 @default.
• W4200517711 cites W2603454965 @default.
• W4200517711 cites W2604523348 @default.
• W4200517711 cites W2606398981 @default.
• W4200517711 cites W2613214396 @default.
• W4200517711 cites W2619080185 @default.

• next