Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200518462> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4200518462 abstract "Maternal genetic variants associated with offspring birth weight and adult type 2 diabetes (T2D) risk loci show some overlap. Whether T2D genetic risk influences longitudinal fetal weight and the gestational timing when these relationships begin is unknown. We investigated the associations of T2D genetic risk score (GRS) with longitudinal fetal weight and birth weight among 1,513 pregnant women from four ancestral groups. Women had up to 5 ultrasonography. Ancestry-matched GRS were constructed separately using 380 European- (GRS<i>eur</i>), 104 African- (GRS<i>afr</i>), and 189 East Asian- (GRS<i>eas</i>) related T2D loci discovered in different population groups. Among European Americans, the highest quartile GRS<i>eur</i> was significantly associated with 53.8 g higher fetal weight (95% confidence interval [CI] 19.2-88.5 g) over the pregnancy. The associations began at gestational week 24 and continued through week 40, with a 106.8 g (95% CI: 6.5-207.1 g) increase in birth weight. The findings were similar in analysis further adjusted for maternal glucose challenge test results. No consistent association was found using ancestry-matched or cross-ancestry GRS in non-Europeans. In conclusion, T2D genetic susceptibility may influence fetal growth starting at mid-second trimester among Europeans. Absence of similar associations in non-Europeans urges the need for further genetic T2D studies in diverse ancestries." @default.
- W4200518462 created "2021-12-31" @default.
- W4200518462 creator A5023594259 @default.
- W4200518462 creator A5024164269 @default.
- W4200518462 creator A5028542613 @default.
- W4200518462 creator A5062730712 @default.
- W4200518462 creator A5076220623 @default.
- W4200518462 date "2021-11-17" @default.
- W4200518462 modified "2023-09-28" @default.
- W4200518462 title "Ancestry-Matched and Cross-Ancestry Genetic Risk Scores of Type 2 Diabetes in Pregnant Women and Fetal Growth—A Study in an Ancestrally Diverse Cohort" @default.
- W4200518462 doi "https://doi.org/10.2337/figshare.16999933" @default.
- W4200518462 hasPublicationYear "2021" @default.
- W4200518462 type Work @default.
- W4200518462 citedByCount "0" @default.
- W4200518462 crossrefType "posted-content" @default.
- W4200518462 hasAuthorship W4200518462A5023594259 @default.
- W4200518462 hasAuthorship W4200518462A5024164269 @default.
- W4200518462 hasAuthorship W4200518462A5028542613 @default.
- W4200518462 hasAuthorship W4200518462A5062730712 @default.
- W4200518462 hasAuthorship W4200518462A5076220623 @default.
- W4200518462 hasBestOaLocation W42005184621 @default.
- W4200518462 hasConcept C112672928 @default.
- W4200518462 hasConcept C126322002 @default.
- W4200518462 hasConcept C131872663 @default.
- W4200518462 hasConcept C134018914 @default.
- W4200518462 hasConcept C144024400 @default.
- W4200518462 hasConcept C149923435 @default.
- W4200518462 hasConcept C172680121 @default.
- W4200518462 hasConcept C2777180221 @default.
- W4200518462 hasConcept C2778376644 @default.
- W4200518462 hasConcept C2779234561 @default.
- W4200518462 hasConcept C2779434492 @default.
- W4200518462 hasConcept C2908647359 @default.
- W4200518462 hasConcept C44249647 @default.
- W4200518462 hasConcept C46973012 @default.
- W4200518462 hasConcept C54355233 @default.
- W4200518462 hasConcept C555293320 @default.
- W4200518462 hasConcept C66322754 @default.
- W4200518462 hasConcept C68443243 @default.
- W4200518462 hasConcept C71924100 @default.
- W4200518462 hasConcept C86803240 @default.
- W4200518462 hasConceptScore W4200518462C112672928 @default.
- W4200518462 hasConceptScore W4200518462C126322002 @default.
- W4200518462 hasConceptScore W4200518462C131872663 @default.
- W4200518462 hasConceptScore W4200518462C134018914 @default.
- W4200518462 hasConceptScore W4200518462C144024400 @default.
- W4200518462 hasConceptScore W4200518462C149923435 @default.
- W4200518462 hasConceptScore W4200518462C172680121 @default.
- W4200518462 hasConceptScore W4200518462C2777180221 @default.
- W4200518462 hasConceptScore W4200518462C2778376644 @default.
- W4200518462 hasConceptScore W4200518462C2779234561 @default.
- W4200518462 hasConceptScore W4200518462C2779434492 @default.
- W4200518462 hasConceptScore W4200518462C2908647359 @default.
- W4200518462 hasConceptScore W4200518462C44249647 @default.
- W4200518462 hasConceptScore W4200518462C46973012 @default.
- W4200518462 hasConceptScore W4200518462C54355233 @default.
- W4200518462 hasConceptScore W4200518462C555293320 @default.
- W4200518462 hasConceptScore W4200518462C66322754 @default.
- W4200518462 hasConceptScore W4200518462C68443243 @default.
- W4200518462 hasConceptScore W4200518462C71924100 @default.
- W4200518462 hasConceptScore W4200518462C86803240 @default.
- W4200518462 hasLocation W42005184621 @default.
- W4200518462 hasLocation W42005184622 @default.
- W4200518462 hasLocation W42005184623 @default.
- W4200518462 hasOpenAccess W4200518462 @default.
- W4200518462 hasPrimaryLocation W42005184621 @default.
- W4200518462 hasRelatedWork W10512665 @default.
- W4200518462 hasRelatedWork W11957777 @default.
- W4200518462 hasRelatedWork W14550711 @default.
- W4200518462 hasRelatedWork W2139894 @default.
- W4200518462 hasRelatedWork W3697404 @default.
- W4200518462 hasRelatedWork W6399536 @default.
- W4200518462 hasRelatedWork W6436733 @default.
- W4200518462 hasRelatedWork W8971033 @default.
- W4200518462 hasRelatedWork W9667040 @default.
- W4200518462 hasRelatedWork W9849857 @default.
- W4200518462 isParatext "false" @default.
- W4200518462 isRetracted "false" @default.
- W4200518462 workType "article" @default.