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• W4200518687 abstract "We aimed to investigate the expression of Klotho gene in peripheral blood of patients with cerebral infarction (CI) and the association of its polymorphisms with the occurrence of CI.A total of 60 CI patients (CI group) and 20 healthy people receiving physical examination (control group) were enrolled as the research subjects. The expression of Klotho gene in CI group and control group was determined using enzyme-linked immunosorbent assay kit. Single nucleotide polymorphisms (rs192031, rs200131 and rs102312) in the promoter region of the Klotho gene were typed via conformational difference gel electrophoresis. Besides, whether the distribution frequencies of Klotho genotypes conformed to Hardy-Weinberg equilibrium was evaluated by chi-square test. Meanwhile, the associations of Klotho alleles and gene polymorphisms with CI occurrence were analyzed.The protein expression level of Klotho in the peripheral blood was remarkably lower in patients in CI group than that in control group (P<0.05).HardyWeinberg equilibrium analysis revealed that Klotho gene polymorphisms (rs192031, rs200131 and rs102312) conformed to the genetic equilibrium distribution (P>0.05). Gene-based association analysis manifested that only rs192031 polymorphism and alleles were correlated with CI occurrence (P<0.05). Systolic blood pressure and highdensity lipoprotein cholesterol were notably higher in CI patients with TT genotype of Klotho gene polymorphism rs192031 than those in control group (P<0.05). Furthermore, there were no associations of rs200131 and rs102312 polymorphisms and alleles with the occurrence of CI (P>0.05).The expression level of Klotho is evidently reduced in the peripheral blood of CI patients. Rs192031 in the promoter region of the Klotho gene is associated with the occurrence of CI, while rs200131 and rs102312 have no relations with CI.Cilj nam je bio da istražimo ekspresiju Klotho gena u perifernoj krvi pacijenata sa cerebralnim infarktom (CI) i povezanost njegovih polimorfizama sa pojavom CI.Ukupno 60 pacijenata sa CI (CI grupa) i 20 zdravih osoba na fizikalnom pregledu (kontrolna grupa) upisano je kao subjekti istraživanja. Ekspresija Klotho gena u CI grupi i kontrolnoj grupi je određena korišćenjem kompleta za en - zimski imunosorbentni test. Polimorfizmi pojedinačnih nukleotida (rs192031, rs200131 i rs102312) u promotorskom regionu Klotho gena su tipizovani putem konformacione razlike u gel elektroforezi. Osim toga, da li su frekvencije distribucije Klotho genotipova u skladu sa Hardy-Wein-bergovom ravnotećom procenjeno je hi-kvadrat testom. U međuvremenu, analizirane su asocijacije Klotho alela i polimorfizama gena sa pojavom CI.Nivo ekspresije proteina Klotho-a u perifernoj krvi bio je značajno niži kod pacijenata u CI grupi nego u kontrolnoj grupi (P<0,05). Hardy-Weinbergova analiza ravnoteže otkrila je da se polimorfizmi Klotho gena (rs192031, rs200131 i rs102312) podudaraju sa distribucija genetičke ravnoteže (P>0,05). Analiza asocijacije zasnovana na genima pokazala je da su samo rs192031 polimorfizam i aleli u korelaciji sa pojavom CI (P<0,05). Sistolni krvni pritisak i holesterol lipoproteina visoke gustine bili su značajno viši kod pacijenata sa CI sa TT genotipom polimorfizma Klotho gena rs192031 od onih u kontrolnoj grupi (P<0,05). Štaviše, nije bilo asocijacija rs200131 i rs102312 polimorfizama i alela sa pojavom CI (P>0,05).Nivo ekspresije Klotho-a je evidentno smanjen u perifernoj krvi pacijenata sa CI. Rs192031 u promotorskom regionu Klotho gena je povezan sa pojavom CI, dok rs200131 i rs102312 nemaju veze sa CI." @default.
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• W4200518687 date "2022-01-01" @default.
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• W4200518687 title "Association of 'Klotho' gene polymorphism with cerebral infarction" @default.
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• W4200518687 doi "https://doi.org/10.5937/jomb0-34196" @default.
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