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• W4200520123 abstract "Unequal cluster sizes are common in cluster randomized trials (CRTs). While there are a number of previous investigations studying the impact of unequal cluster sizes on the power for testing the average treatment effect in CRTs, little is known about the impact of unequal cluster sizes on the power for testing the heterogeneous treatment effect (HTE) in CRTs. In this work, we expand the sample size procedures for studying HTE in CRTs to accommodate cluster size variation under the linear mixed model framework. Through analytical derivation and graphical exploration, we show that the sample size for the HTE with an individual-level effect modifier is less affected by unequal cluster sizes than with a cluster-level effect modifier. The impact of cluster size variability jointly depends on the mean and coefficient of variation of cluster sizes, covariate intraclass correlation coefficient (ICC) and the conditional outcome ICC. In addition, we demonstrate that the HTE-motivated analysis of covariance framework can be used for analyzing the average treatment effect, and offer a more efficient sample size procedure for studying the average treatment effect adjusting for the effect modifier. We use simulations to confirm the accuracy of the proposed sample size procedures for both the average treatment effect and HTE in CRTs. Extensions to multivariate effect modifiers are provided and our procedure is illustrated in the context of the Strategies to Reduce Injuries and Develop Confidence in Elders trial." @default.
• W4200520123 created "2021-12-31" @default.
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• W4200520123 creator A5044812776 @default.
• W4200520123 date "2021-12-19" @default.
• W4200520123 modified "2023-10-16" @default.
• W4200520123 title "Accounting for unequal cluster sizes in designing cluster randomized trials to detect treatment effect heterogeneity" @default.
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• W4200520123 doi "https://doi.org/10.1002/sim.9283" @default.
• W4200520123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34923655" @default.
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