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• W4200520501 endingPage "152703" @default.
• W4200520501 startingPage "152703" @default.
• W4200520501 abstract "The frequent occurrence of antibiotics in source waters may affect the formation of harmful algal blooms (HABs) dominated by the cyanobacterium Microcystis aeruginosa. However, it remains poorly understood whether dissolved algal organic matters (AOM) can be altered by the introduction of antibiotics in source waters. To resolve these discrepancies, this study investigated the physiological, biochemical, and transcriptional responses of a toxigenic strain of M. aeruginosa to the commonly-detected antibiotic roxithromycin (ROX) at environmentally relevant concentrations ranging from 30 to 8000 ng L-1. The growth and microcystin (MC) production of M. aeruginosa was significantly stimulated by 300 and 1000 ng L-1 ROX, whereas inhibited by 5000 and 8000 ng L-1 ROX. This may be owing to the regulation of genes related to photosynthesis and MCs. Although the membrane of cyanobacterial cells remained intact, the release of MCs was increased significantly with the growing ROX dosages, which may cause additional challenges in drinking water treatment. The amounts of AOM were enhanced by 300 and 1000 ng L-1 ROX, while decreased by 5000 and 8000 ng L-1 ROX. It may be attributed to the changes of cyanobacterial cell growth and the gene expression related to carbon fixation, carbohydrate metabolism and nitrogen metabolism. To further understand the regulation of related genes in M. aeruginosa exposed to ROX, trend analysis of differentially expressed genes was performed. The results indicated that the regulation of metabolism-related genes (e.g., lipopolysaccharide biosynthesis) may be also responsible for the changes of cyanobacterial cell densities. Generally, low levels of ROX (300 and 1000 ng L-1) could stimulated the cyanobacterial growth, MC synthesis and AOM production, which may promote the formation of HABs and reduce the source water quality. Although higher levels of ROX (5000 and 8000 ng L-1) inhibited the formation of HABs, the threat of increasing extracellular MCs should be considered." @default.
• W4200520501 created "2021-12-31" @default.
• W4200520501 creator A5034710072 @default.
• W4200520501 creator A5048933747 @default.
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• W4200520501 date "2022-03-01" @default.
• W4200520501 modified "2023-10-16" @default.
• W4200520501 title "Physiological, biochemical and transcriptional responses of cyanobacteria to environmentally relevant concentrations of a typical antibiotic—roxithromycin" @default.
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• W4200520501 doi "https://doi.org/10.1016/j.scitotenv.2021.152703" @default.
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