Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200523912> ?p ?o ?g. }
- W4200523912 abstract "Bartonella spp. are facultative intracellular pathogens that infect a wide range of mammalian hosts including humans. The VirB/VirD4 type IV secretion system (T4SS) is a key virulence factor utilized to translocate Bartonella effector proteins (Beps) into host cells in order to subvert their functions. Crucial for effector translocation is the C-terminal Bep intracellular delivery (BID) domain that together with a positively charged tail sequence forms a bipartite translocation signal. Multiple BID domains also evolved secondary effector functions within host cells. The majority of Beps possess an N-terminal filamentation induced by cAMP (FIC) domain and a central connecting oligonucleotide binding (OB) fold. FIC domains typically mediate AMPylation or related post-translational modifications of target proteins. Some Beps harbor other functional modules, such as tandem-repeated tyrosine-phosphorylation (EPIYA-related) motifs. Within host cells the EPIYA-related motifs are phosphorylated, which facilitates the interaction with host signaling proteins. In this review, we will summarize our current knowledge on the molecular functions of the different domains present in Beps and highlight examples of Bep-dependent host cell modulation." @default.
- W4200523912 created "2021-12-31" @default.
- W4200523912 creator A5018962844 @default.
- W4200523912 creator A5038642433 @default.
- W4200523912 date "2021-12-15" @default.
- W4200523912 modified "2023-09-29" @default.
- W4200523912 title "The Impact of Bartonella VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells" @default.
- W4200523912 cites W1186606388 @default.
- W4200523912 cites W1590138776 @default.
- W4200523912 cites W1598166759 @default.
- W4200523912 cites W1919712230 @default.
- W4200523912 cites W1968541721 @default.
- W4200523912 cites W1973232510 @default.
- W4200523912 cites W1976566902 @default.
- W4200523912 cites W1978517760 @default.
- W4200523912 cites W1983767314 @default.
- W4200523912 cites W1998408165 @default.
- W4200523912 cites W2003448359 @default.
- W4200523912 cites W2011747741 @default.
- W4200523912 cites W2027777116 @default.
- W4200523912 cites W2032432541 @default.
- W4200523912 cites W2036467696 @default.
- W4200523912 cites W2039220900 @default.
- W4200523912 cites W2043661964 @default.
- W4200523912 cites W2044702107 @default.
- W4200523912 cites W2055802786 @default.
- W4200523912 cites W2056979628 @default.
- W4200523912 cites W2065973221 @default.
- W4200523912 cites W2067613735 @default.
- W4200523912 cites W2072760254 @default.
- W4200523912 cites W2078738962 @default.
- W4200523912 cites W2082610876 @default.
- W4200523912 cites W2084734004 @default.
- W4200523912 cites W2089002984 @default.
- W4200523912 cites W2089594628 @default.
- W4200523912 cites W2090188358 @default.
- W4200523912 cites W2097165693 @default.
- W4200523912 cites W2097254806 @default.
- W4200523912 cites W2116552697 @default.
- W4200523912 cites W2118874922 @default.
- W4200523912 cites W2119852931 @default.
- W4200523912 cites W2122301597 @default.
- W4200523912 cites W2123617460 @default.
- W4200523912 cites W2129196764 @default.
- W4200523912 cites W2147491616 @default.
- W4200523912 cites W2151173508 @default.
- W4200523912 cites W2155208388 @default.
- W4200523912 cites W2159165131 @default.
- W4200523912 cites W2160511815 @default.
- W4200523912 cites W2171392588 @default.
- W4200523912 cites W2307025906 @default.
- W4200523912 cites W2345774905 @default.
- W4200523912 cites W2409724360 @default.
- W4200523912 cites W2553282380 @default.
- W4200523912 cites W2592841058 @default.
- W4200523912 cites W2768292356 @default.
- W4200523912 cites W2900557017 @default.
- W4200523912 cites W2906052725 @default.
- W4200523912 cites W2907457004 @default.
- W4200523912 cites W2910038189 @default.
- W4200523912 cites W2922159598 @default.
- W4200523912 cites W2943133037 @default.
- W4200523912 cites W2974154647 @default.
- W4200523912 cites W2996420143 @default.
- W4200523912 cites W2998342995 @default.
- W4200523912 cites W3008057350 @default.
- W4200523912 cites W3010864714 @default.
- W4200523912 cites W3112486435 @default.
- W4200523912 cites W3122388062 @default.
- W4200523912 cites W3125875296 @default.
- W4200523912 cites W3139344756 @default.
- W4200523912 cites W3192397504 @default.
- W4200523912 doi "https://doi.org/10.3389/fmicb.2021.762582" @default.
- W4200523912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34975788" @default.
- W4200523912 hasPublicationYear "2021" @default.
- W4200523912 type Work @default.
- W4200523912 citedByCount "4" @default.
- W4200523912 countsByYear W42005239122022 @default.
- W4200523912 countsByYear W42005239122023 @default.
- W4200523912 crossrefType "journal-article" @default.
- W4200523912 hasAuthorship W4200523912A5018962844 @default.
- W4200523912 hasAuthorship W4200523912A5038642433 @default.
- W4200523912 hasBestOaLocation W42005239121 @default.
- W4200523912 hasConcept C104317684 @default.
- W4200523912 hasConcept C126831891 @default.
- W4200523912 hasConcept C153726182 @default.
- W4200523912 hasConcept C188018408 @default.
- W4200523912 hasConcept C49039625 @default.
- W4200523912 hasConcept C51785407 @default.
- W4200523912 hasConcept C54355233 @default.
- W4200523912 hasConcept C55493867 @default.
- W4200523912 hasConcept C60987743 @default.
- W4200523912 hasConcept C79879829 @default.
- W4200523912 hasConcept C86803240 @default.
- W4200523912 hasConcept C95444343 @default.
- W4200523912 hasConceptScore W4200523912C104317684 @default.
- W4200523912 hasConceptScore W4200523912C126831891 @default.
- W4200523912 hasConceptScore W4200523912C153726182 @default.
- W4200523912 hasConceptScore W4200523912C188018408 @default.
- W4200523912 hasConceptScore W4200523912C49039625 @default.