Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200526169> ?p ?o ?g. }
- W4200526169 abstract "Oligonucleotides containing cleavable linkers have emerged as versatile tools to achieve stimulus-responsive and site-specific cleavage of DNA. However, the limitations of previously reported cleavable linkers including photolabile and disulfide linkers have restricted their applications in vivo. Inspired by the cathepsin B-sensitive dipeptide linkers in antibody-drug conjugates (ADCs) such as Adcetris, we have developed Val-Ala-02 and Val-Ala-Chalcone phosphoramidites for the automated synthesis of enzyme-cleavable oligonucleotides. Cathepsin B digests Val-Ala-02 and Val-Ala-Chalcone linkers efficiently, enabling cleavage of oligonucleotides into two components or release of small-molecule payloads. Based on the prior success of dipeptide linkers in ADCs, we believe that these dipeptide linker phosphoramidites will promote new clinical applications of therapeutic oligonucleotides." @default.
- W4200526169 created "2021-12-31" @default.
- W4200526169 creator A5002164849 @default.
- W4200526169 creator A5012443982 @default.
- W4200526169 creator A5024421064 @default.
- W4200526169 creator A5072432989 @default.
- W4200526169 creator A5074404084 @default.
- W4200526169 creator A5074565235 @default.
- W4200526169 date "2022-02-10" @default.
- W4200526169 modified "2023-10-14" @default.
- W4200526169 title "Engineering Enzyme‐Cleavable Oligonucleotides by Automated Solid‐Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers" @default.
- W4200526169 cites W1484675846 @default.
- W4200526169 cites W1822869875 @default.
- W4200526169 cites W1974024002 @default.
- W4200526169 cites W1995513865 @default.
- W4200526169 cites W2001155370 @default.
- W4200526169 cites W2002767447 @default.
- W4200526169 cites W2011937157 @default.
- W4200526169 cites W2014756142 @default.
- W4200526169 cites W2023013315 @default.
- W4200526169 cites W2039288218 @default.
- W4200526169 cites W2042406691 @default.
- W4200526169 cites W2053996189 @default.
- W4200526169 cites W2092528383 @default.
- W4200526169 cites W2128779315 @default.
- W4200526169 cites W2141368947 @default.
- W4200526169 cites W2156506990 @default.
- W4200526169 cites W2169350127 @default.
- W4200526169 cites W2303964045 @default.
- W4200526169 cites W2474157905 @default.
- W4200526169 cites W2582812828 @default.
- W4200526169 cites W2597045666 @default.
- W4200526169 cites W2750173239 @default.
- W4200526169 cites W2761114443 @default.
- W4200526169 cites W2783268592 @default.
- W4200526169 cites W2803566305 @default.
- W4200526169 cites W2809014346 @default.
- W4200526169 cites W2907422601 @default.
- W4200526169 cites W2945727406 @default.
- W4200526169 cites W2958576566 @default.
- W4200526169 cites W2978718877 @default.
- W4200526169 cites W2999487447 @default.
- W4200526169 cites W3010682444 @default.
- W4200526169 cites W3010805080 @default.
- W4200526169 cites W3036442269 @default.
- W4200526169 cites W3094044183 @default.
- W4200526169 cites W3180194790 @default.
- W4200526169 cites W4200526169 @default.
- W4200526169 cites W4210818358 @default.
- W4200526169 cites W4229976774 @default.
- W4200526169 cites W4243040611 @default.
- W4200526169 doi "https://doi.org/10.1002/anie.202114016" @default.
- W4200526169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34953094" @default.
- W4200526169 hasPublicationYear "2022" @default.
- W4200526169 type Work @default.
- W4200526169 citedByCount "7" @default.
- W4200526169 countsByYear W42005261692022 @default.
- W4200526169 countsByYear W42005261692023 @default.
- W4200526169 crossrefType "journal-article" @default.
- W4200526169 hasAuthorship W4200526169A5002164849 @default.
- W4200526169 hasAuthorship W4200526169A5012443982 @default.
- W4200526169 hasAuthorship W4200526169A5024421064 @default.
- W4200526169 hasAuthorship W4200526169A5072432989 @default.
- W4200526169 hasAuthorship W4200526169A5074404084 @default.
- W4200526169 hasAuthorship W4200526169A5074565235 @default.
- W4200526169 hasBestOaLocation W42005261691 @default.
- W4200526169 hasConcept C111919701 @default.
- W4200526169 hasConcept C129312508 @default.
- W4200526169 hasConcept C151730666 @default.
- W4200526169 hasConcept C161624437 @default.
- W4200526169 hasConcept C175156509 @default.
- W4200526169 hasConcept C181199279 @default.
- W4200526169 hasConcept C185592680 @default.
- W4200526169 hasConcept C21951064 @default.
- W4200526169 hasConcept C2776469878 @default.
- W4200526169 hasConcept C2779138802 @default.
- W4200526169 hasConcept C2779281246 @default.
- W4200526169 hasConcept C2780557392 @default.
- W4200526169 hasConcept C28021979 @default.
- W4200526169 hasConcept C41008148 @default.
- W4200526169 hasConcept C43369102 @default.
- W4200526169 hasConcept C552990157 @default.
- W4200526169 hasConcept C55493867 @default.
- W4200526169 hasConcept C71240020 @default.
- W4200526169 hasConcept C86803240 @default.
- W4200526169 hasConceptScore W4200526169C111919701 @default.
- W4200526169 hasConceptScore W4200526169C129312508 @default.
- W4200526169 hasConceptScore W4200526169C151730666 @default.
- W4200526169 hasConceptScore W4200526169C161624437 @default.
- W4200526169 hasConceptScore W4200526169C175156509 @default.
- W4200526169 hasConceptScore W4200526169C181199279 @default.
- W4200526169 hasConceptScore W4200526169C185592680 @default.
- W4200526169 hasConceptScore W4200526169C21951064 @default.
- W4200526169 hasConceptScore W4200526169C2776469878 @default.
- W4200526169 hasConceptScore W4200526169C2779138802 @default.
- W4200526169 hasConceptScore W4200526169C2779281246 @default.
- W4200526169 hasConceptScore W4200526169C2780557392 @default.
- W4200526169 hasConceptScore W4200526169C28021979 @default.
- W4200526169 hasConceptScore W4200526169C41008148 @default.
- W4200526169 hasConceptScore W4200526169C43369102 @default.