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- W4200526936 abstract "Historically, chorioamnionitis has been thought to result from ascending microbes driving inflammation of the chorioamnion, and is associated with PTB, perinatal morbidity, and adverse fetal outcomes. However, pathophysiology studies in humans suggest that it results from focal membrane colonization. Here, we studied the extent and spread of chorioamnionitis in non-human primates induced by sterile intraamniotic injection (IA) of IL1β, LPS, or Ureaplasma parvum (UP). Under ultrasound guidance, intraamniotic injections of saline, 1mg LPS (E. coli 055:B5), 10μg IL-1β, or 107 CFU Ureaplasma parvum were given to preterm (126-132 days) Rhesus macaques (n=40). Placenta, amniotic fluid, and colon samples were collected for cytokine expression study and placenta and colon tissues were used for histopathology. IL-1β treatment induced histologic acute chorioamnionitis, whereas LPS induced acute subchorionitis. However, no membrane infiltration was observed in any of the colon samples, as well as the placenta samples with Ureaplasma IA. Significant (p< 0.01) increases in neutrophils and proinflammatory cytokines like IL-6, IL-8, IL-10, and MCP-1 was observed in amniotic fluid 16 h post intra-amniotic LPS or 48 h post IL-1β injection. There are three significant findings of importance: (1) chorioamnionitis is accompanied by intrauterine but not proximal tissue (gut) nor systemic inflammation, (2) Ureaplasma does not induce intrauterine inflammation with injection, and (3) in contrast, sterile pro-inflammatory cytokines do induce histologically evident chorioamnionits in a Rhesus macaque model.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
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- W4200526936 date "2022-01-01" @default.
- W4200526936 modified "2023-09-25" @default.
- W4200526936 title "LPS, IL-1β or U. parvum-induced chorioamnionitis shows pro-inflammatory signatures in amniotic fluid and placental tissue" @default.
- W4200526936 doi "https://doi.org/10.1016/j.ajog.2021.11.064" @default.
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