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- W4200527470 abstract "The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage tracing and single-cell transcriptomics to investigate the mechanisms underlying this process in primary human islet cells. Using drug-induced ER stress and cytoskeleton modification models, we demonstrate that altering the islet structure triggers an unfolding protein response that causes the downregulation of β-cell maturity genes. Collectively, our findings illustrate the close relationship between endoplasmic reticulum homeostasis and β-cell phenotype, and strengthen the concept of altered β-cell identity as a mechanism underlying the loss of functional β-cell mass." @default.
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- W4200527470 date "2021-12-19" @default.
- W4200527470 modified "2023-10-14" @default.
- W4200527470 title "Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress" @default.
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- W4200527470 doi "https://doi.org/10.3390/cells10123585" @default.
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