Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200529219> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4200529219 abstract "Nature connects multiple fuel-driven chemical/enzymatic reaction networks (CRNs/ERNs) via cross-regulation to hierarchically control biofunctions for a tailored adaption in complex sensory landscapes. In contrast, emerging artificial fuel-driven systems most-ly focus on a single CRN and their implementation to direct self-assembly or material responses. In this work, we introduce a facile example of communication and cross-regulation among multiple DNA-based ERNs regulated by a concatenated RNA transcription regulator. For this purpose, we run two fuel-driven DNA-based ERNs by concurrent NAD+-fueled ligation and restriction via endo-nucleases (REases) in parallel. ERN one allows for the dynamic steady-state formation of the promoter sequence for T7 RNA poly-merase, which activates RNA transcription. The produced RNA regulator can repress or promote the second ERN via RNA-mediated strand displacement. Furthermore, adding RNase H to degrade the produced RNA can restart the reaction or tune the lag time of two ERNs, giving rise to a repression-recovery and promotion-stop processes. We believe that concatenation of multiple CRNs provides a basis for the design of more elaborate autonomous regulatory mechanisms in systems chemistry and synthetic biology." @default.
- W4200529219 created "2021-12-31" @default.
- W4200529219 creator A5018406941 @default.
- W4200529219 creator A5019312823 @default.
- W4200529219 creator A5022279219 @default.
- W4200529219 date "2021-12-14" @default.
- W4200529219 modified "2023-10-16" @default.
- W4200529219 title "Communication and Cross-Regulation Between Multiple Concatenated Enzymatic Reaction Networks" @default.
- W4200529219 doi "https://doi.org/10.26434/chemrxiv-2021-l3hzf" @default.
- W4200529219 hasPublicationYear "2021" @default.
- W4200529219 type Work @default.
- W4200529219 citedByCount "0" @default.
- W4200529219 crossrefType "posted-content" @default.
- W4200529219 hasAuthorship W4200529219A5018406941 @default.
- W4200529219 hasAuthorship W4200529219A5019312823 @default.
- W4200529219 hasAuthorship W4200529219A5022279219 @default.
- W4200529219 hasBestOaLocation W42005292191 @default.
- W4200529219 hasConcept C104317684 @default.
- W4200529219 hasConcept C10879258 @default.
- W4200529219 hasConcept C138885662 @default.
- W4200529219 hasConcept C179926584 @default.
- W4200529219 hasConcept C185592680 @default.
- W4200529219 hasConcept C191908910 @default.
- W4200529219 hasConcept C41008148 @default.
- W4200529219 hasConcept C41895202 @default.
- W4200529219 hasConcept C552990157 @default.
- W4200529219 hasConcept C55493867 @default.
- W4200529219 hasConcept C67705224 @default.
- W4200529219 hasConcept C6929976 @default.
- W4200529219 hasConcept C70721500 @default.
- W4200529219 hasConcept C83640560 @default.
- W4200529219 hasConcept C86803240 @default.
- W4200529219 hasConcept C95444343 @default.
- W4200529219 hasConceptScore W4200529219C104317684 @default.
- W4200529219 hasConceptScore W4200529219C10879258 @default.
- W4200529219 hasConceptScore W4200529219C138885662 @default.
- W4200529219 hasConceptScore W4200529219C179926584 @default.
- W4200529219 hasConceptScore W4200529219C185592680 @default.
- W4200529219 hasConceptScore W4200529219C191908910 @default.
- W4200529219 hasConceptScore W4200529219C41008148 @default.
- W4200529219 hasConceptScore W4200529219C41895202 @default.
- W4200529219 hasConceptScore W4200529219C552990157 @default.
- W4200529219 hasConceptScore W4200529219C55493867 @default.
- W4200529219 hasConceptScore W4200529219C67705224 @default.
- W4200529219 hasConceptScore W4200529219C6929976 @default.
- W4200529219 hasConceptScore W4200529219C70721500 @default.
- W4200529219 hasConceptScore W4200529219C83640560 @default.
- W4200529219 hasConceptScore W4200529219C86803240 @default.
- W4200529219 hasConceptScore W4200529219C95444343 @default.
- W4200529219 hasLocation W42005292191 @default.
- W4200529219 hasOpenAccess W4200529219 @default.
- W4200529219 hasPrimaryLocation W42005292191 @default.
- W4200529219 hasRelatedWork W1966103612 @default.
- W4200529219 hasRelatedWork W2010603372 @default.
- W4200529219 hasRelatedWork W2015146829 @default.
- W4200529219 hasRelatedWork W2022965478 @default.
- W4200529219 hasRelatedWork W2034544470 @default.
- W4200529219 hasRelatedWork W2041019796 @default.
- W4200529219 hasRelatedWork W2085300355 @default.
- W4200529219 hasRelatedWork W2143540931 @default.
- W4200529219 hasRelatedWork W2403732661 @default.
- W4200529219 hasRelatedWork W2999184291 @default.
- W4200529219 isParatext "false" @default.
- W4200529219 isRetracted "false" @default.
- W4200529219 workType "article" @default.