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- W4200529384 abstract "Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects. The strong antitumor effect of bufadienolides has attracted considerable attention in recent years, but the clinical application of bufadienolides is limited due to their low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored, such as structural modification, solid dispersion, cyclodextrin inclusion, microemulsion and nanodrug delivery systems, etc. In this review, we have tried to summarize the pharmacological activities and structure-activity relationship of bufadienolides. Furthermore, the strategies for solubility and bioavailability enhancement of bufadienolides also are discussed. This review can provide a basis for further study on bufadienolides." @default.
- W4200529384 created "2021-12-31" @default.
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- W4200529384 creator A5089966579 @default.
- W4200529384 date "2021-12-22" @default.
- W4200529384 modified "2023-10-11" @default.
- W4200529384 title "Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides" @default.
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