FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200529404> ?p ?o ?g. }

• W4200529404 abstract "Biological aging may occur at different rates than chronological aging due to genetic, social, and environmental factors. DNA methylation (DNAm) age is thought to be a reliable measure of accelerated biological aging which has been linked to an array of poor health outcomes. Given the importance of chronological age in recovery following aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke, DNAm age may also be an important biomarker of outcomes, further improving predictive models. Cerebrospinal fluid (CSF) is a unique tissue representing the local central nervous system environment post-aSAH. However, the validity of CSF DNAm age is unknown, and it is unclear which epigenetic clock is ideal to compute CSF DNAm age, particularly given changes in cell type heterogeneity (CTH) during the acute recovery period. Further, the stability of DNAm age post-aSAH, specifically, has not been examined and may improve our understanding of patient recovery post-aSAH. Therefore, the purpose of this study was to characterize CSF DNAm age over 14 days post-aSAH using four epigenetic clocks.Genome-wide DNAm data were available for two tissues: (1) CSF for N = 273 participants with serial sampling over 14 days post-aSAH (N = 850 samples) and (2) blood for a subset of n = 72 participants at one time point post-aSAH. DNAm age was calculated using the Horvath, Hannum, Levine, and Improved Precision (Zhang) epigenetic clocks. Age acceleration was computed as the residuals of DNAm age regressed on chronological age both with and without correcting for CTH. Using scatterplots, Pearson correlations, and group-based trajectory analysis, we examined the relationships between CSF DNAm age and chronological age, the concordance between DNAm ages calculated from CSF versus blood, and the stability (i.e., trajectories) of CSF DNAm age acceleration over time during recovery from aSAH. We observed moderate to strong correlations between CSF DNAm age and chronological age (R = 0.66 [Levine] to R = 0.97 [Zhang]), moderate to strong correlations between DNAm age in CSF versus blood (R = 0.69 [Levine] to R = 0.98 [Zhang]), and stable CSF age acceleration trajectories over 14 days post-aSAH in the Horvath and Zhang clocks (unadjusted for CTH), as well as the Hannum clock (adjusted for CTH).CSF DNAm age was generally stable post-aSAH. Although correlated, CSF DNAm age differs from blood DNAm age in the Horvath, Hannum, and Levine clocks, but not in the Zhang clock. Taken together, our results suggest that, of the clocks examined here, the Zhang clock is the most robust to CTH and is recommended for use in complex tissues such as CSF." @default.
• W4200529404 created "2021-12-31" @default.
• W4200529404 creator A5033510739 @default.
• W4200529404 creator A5035793544 @default.
• W4200529404 creator A5045139528 @default.
• W4200529404 creator A5085494924 @default.
• W4200529404 creator A5087068903 @default.
• W4200529404 date "2021-12-01" @default.
• W4200529404 modified "2023-10-13" @default.
• W4200529404 title "Characterization of cerebrospinal fluid DNA methylation age during the acute recovery period following aneurysmal subarachnoid hemorrhage" @default.
• W4200529404 cites W1891158457 @default.
• W4200529404 cites W1974047233 @default.
• W4200529404 cites W1997944093 @default.
• W4200529404 cites W2004511032 @default.
• W4200529404 cites W2013071495 @default.
• W4200529404 cites W2019286511 @default.
• W4200529404 cites W2029372700 @default.
• W4200529404 cites W2035476209 @default.
• W4200529404 cites W2059389984 @default.
• W4200529404 cites W2060752639 @default.
• W4200529404 cites W2118094114 @default.
• W4200529404 cites W2119883345 @default.
• W4200529404 cites W2121091193 @default.
• W4200529404 cites W2127874289 @default.
• W4200529404 cites W2159536887 @default.
• W4200529404 cites W2160233610 @default.
• W4200529404 cites W2170324063 @default.
• W4200529404 cites W2170357404 @default.
• W4200529404 cites W2202178422 @default.
• W4200529404 cites W2347100089 @default.
• W4200529404 cites W2503964352 @default.
• W4200529404 cites W2505539351 @default.
• W4200529404 cites W2545208659 @default.
• W4200529404 cites W2557295976 @default.
• W4200529404 cites W2618311580 @default.
• W4200529404 cites W2778824377 @default.
• W4200529404 cites W2786473728 @default.
• W4200529404 cites W2790137094 @default.
• W4200529404 cites W2796559433 @default.
• W4200529404 cites W2917830189 @default.
• W4200529404 cites W2949100461 @default.
• W4200529404 cites W2965256346 @default.
• W4200529404 cites W2969410982 @default.
• W4200529404 cites W2990428470 @default.
• W4200529404 cites W2996718942 @default.
• W4200529404 cites W3013089584 @default.
• W4200529404 cites W3037305338 @default.
• W4200529404 cites W3083730060 @default.
• W4200529404 cites W3093934958 @default.
• W4200529404 cites W3210998569 @default.
• W4200529404 cites W4211004345 @default.
• W4200529404 doi "https://doi.org/10.1186/s43682-021-00002-6" @default.
• W4200529404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35083469" @default.
• W4200529404 hasPublicationYear "2021" @default.
• W4200529404 type Work @default.
• W4200529404 citedByCount "2" @default.
• W4200529404 countsByYear W42005294042022 @default.
• W4200529404 countsByYear W42005294042023 @default.
• W4200529404 crossrefType "journal-article" @default.
• W4200529404 hasAuthorship W4200529404A5033510739 @default.
• W4200529404 hasAuthorship W4200529404A5035793544 @default.
• W4200529404 hasAuthorship W4200529404A5045139528 @default.
• W4200529404 hasAuthorship W4200529404A5085494924 @default.
• W4200529404 hasAuthorship W4200529404A5087068903 @default.
• W4200529404 hasBestOaLocation W42005294041 @default.
• W4200529404 hasConcept C104317684 @default.
• W4200529404 hasConcept C126322002 @default.
• W4200529404 hasConcept C143998085 @default.
• W4200529404 hasConcept C150194340 @default.
• W4200529404 hasConcept C190727270 @default.
• W4200529404 hasConcept C2775921022 @default.
• W4200529404 hasConcept C2777736543 @default.
• W4200529404 hasConcept C2779651940 @default.
• W4200529404 hasConcept C2781197716 @default.
• W4200529404 hasConcept C41091548 @default.
• W4200529404 hasConcept C54355233 @default.
• W4200529404 hasConcept C60644358 @default.
• W4200529404 hasConcept C71924100 @default.
• W4200529404 hasConcept C86803240 @default.
• W4200529404 hasConceptScore W4200529404C104317684 @default.
• W4200529404 hasConceptScore W4200529404C126322002 @default.
• W4200529404 hasConceptScore W4200529404C143998085 @default.
• W4200529404 hasConceptScore W4200529404C150194340 @default.
• W4200529404 hasConceptScore W4200529404C190727270 @default.
• W4200529404 hasConceptScore W4200529404C2775921022 @default.
• W4200529404 hasConceptScore W4200529404C2777736543 @default.
• W4200529404 hasConceptScore W4200529404C2779651940 @default.
• W4200529404 hasConceptScore W4200529404C2781197716 @default.
• W4200529404 hasConceptScore W4200529404C41091548 @default.
• W4200529404 hasConceptScore W4200529404C54355233 @default.
• W4200529404 hasConceptScore W4200529404C60644358 @default.
• W4200529404 hasConceptScore W4200529404C71924100 @default.
• W4200529404 hasConceptScore W4200529404C86803240 @default.
• W4200529404 hasFunder F4320337353 @default.
• W4200529404 hasFunder F4320337472 @default.
• W4200529404 hasIssue "1" @default.
• W4200529404 hasLocation W42005294041 @default.
• W4200529404 hasLocation W42005294042 @default.
• W4200529404 hasLocation W42005294043 @default.
• W4200529404 hasOpenAccess W4200529404 @default.

• next