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- W4200530879 abstract "Les cofacteurs de l'anaphylaxie, présents dans jusqu'à 30 % des cas, renvoient à la recherche de circonstances aggravantes qui conduisent à des réactions cliniques plus sévères. Les médicaments jouent un rôle déterminant comme les anti-inflammatoires non stéroïdiens, les bêtabloquants, les inhibiteurs de l'enzyme de conversion, les sartans, les inhibiteurs de pompe à protons et les statines. Certaines situations comme les infections aiguës, l'exercice, la consommation d'alcool ainsi que les comorbidités des patients (asthme, maladies cardiovasculaires, pathologies mastocytaires) constituent d'autres cofacteurs identifiés. L'influence de certaines hormones comme les œstrogènes pourrait jouer un rôle dans l'anaphylaxie sévère. Récemment, l'hyper-alpha-tryptasémie héréditaire responsable de l'élévation de la tryptase basale plasmatique constitue un facteur de risque de l'anaphylaxie en particulier aux hyménoptères. The cofactors of anaphylaxis, seen in up to 30 % of cases, require screening for any of the aggravating circumstances that can cause the most severe clinical reactions. Drugs play a key role in this respect, with the following having all been incriminated: NSAlDs, beta-blockers, ACE inhibitors, angiotensin II receptor antagonists, proton-pump inhibitors and statins. Certain situations such as acute infections, exercise, alcohol consumption and patients' comorbidities (e.g., asthma, cardiovascular disease, mastocytosis) constitute further identified cofactors. The effect of certain hormones such as estrogens could play a role in the severity of anaphylaxis. The recently described elevation basal serum tryptase, hereditary alpha-tryptasemia has been reported to impact severe anaphylaxis notably in hymenoptera venom allergy." @default.
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- W4200530879 date "2021-12-01" @default.
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- W4200530879 title "Les facteurs de risque et cofacteurs de l'anaphylaxie" @default.
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- W4200530879 doi "https://doi.org/10.1016/s1877-0320(21)00436-x" @default.
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