FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200532016> ?p ?o ?g. }

• W4200532016 endingPage "153055" @default.
• W4200532016 startingPage "153055" @default.
• W4200532016 abstract "Both long-term and short-term alcohol consumption can cause internal homeostasis imbalance, and they have been proved to be related to the initiation and development of atrial fibrillation (AF). Ferroptosis is an iron-dependent form of non-apoptotic oxidative death which also regulate the cell death homeostasis, but whether it involves in AF induced by alcohol consumption remains unclear. Here, we report a study on the effect of ferroptosis on susceptibility to AF at different alcohol consumption frequencies. We divided the mice into single or frequent excessive alcohol consumption group which given sterile drinking water or alcohol by gavage at different frequencies. Meanwhile, the experimental group was given an intraperitoneal injection of ferroptosis inhibitor (Fer-1) before alcohol drinking. It was found that once exposure to 5 g/kg/d frequent excessive alcohol consumption, compared with the single excessive alcohol consumption group, the mice serum non-heme iron concentration, accumulation of iron and oxidative stress reaction in atrial tissues were increased, while the body weight, heart weight and heart weight to tibia length (HW/TL) ratio were decreased. In addition, the inducibility rate of AF increased, while RR interval, effective refractory periods (ERPs) and 90 % action potential duration (APD90) shortened, as well as QTc interval prolonged. Furthermore, the protein and mRNA expression levels of GPx4, FTL, FTH1, Kv1.5, Kv2.1, Kv4.3, Cav1.2, Serca2α, p-PLB were down-regulated, while PTGS2 was up-regulated. Most of the changes can be partially or completely reversed by Fer-1. These results suggest that frequent excessive alcohol consumption activates ferroptosis and increases the inducibility rate of AF. Nevertheless, inhibition of ferroptosis can balance iron overload disorders and reduce the generation of reactive oxygen species (ROS), eventually decrease the susceptibility to AF. Our results highlight the importance of guidance and warnings for unhealthy alcohol-abuse lifestyle." @default.
• W4200532016 created "2021-12-31" @default.
• W4200532016 creator A5022270596 @default.
• W4200532016 creator A5023102000 @default.
• W4200532016 creator A5023868028 @default.
• W4200532016 creator A5031499083 @default.
• W4200532016 creator A5033033828 @default.
• W4200532016 creator A5034305048 @default.
• W4200532016 creator A5045490292 @default.
• W4200532016 creator A5061940416 @default.
• W4200532016 creator A5066384705 @default.
• W4200532016 creator A5077388601 @default.
• W4200532016 creator A5077574174 @default.
• W4200532016 creator A5085028455 @default.
• W4200532016 date "2022-01-01" @default.
• W4200532016 modified "2023-10-17" @default.
• W4200532016 title "Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation" @default.
• W4200532016 cites W151616777 @default.
• W4200532016 cites W1589007430 @default.
• W4200532016 cites W1987171553 @default.
• W4200532016 cites W1997183854 @default.
• W4200532016 cites W2002490399 @default.
• W4200532016 cites W2028585334 @default.
• W4200532016 cites W2035898183 @default.
• W4200532016 cites W2074892323 @default.
• W4200532016 cites W2096080244 @default.
• W4200532016 cites W2140665078 @default.
• W4200532016 cites W2265062179 @default.
• W4200532016 cites W2470889344 @default.
• W4200532016 cites W2607238069 @default.
• W4200532016 cites W2610079580 @default.
• W4200532016 cites W2611610643 @default.
• W4200532016 cites W2767414526 @default.
• W4200532016 cites W2773404048 @default.
• W4200532016 cites W2788640168 @default.
• W4200532016 cites W2804551710 @default.
• W4200532016 cites W2889517514 @default.
• W4200532016 cites W2890214476 @default.
• W4200532016 cites W2902425824 @default.
• W4200532016 cites W2912101705 @default.
• W4200532016 cites W2914574872 @default.
• W4200532016 cites W2918678782 @default.
• W4200532016 cites W2919513611 @default.
• W4200532016 cites W2935369648 @default.
• W4200532016 cites W2969617477 @default.
• W4200532016 cites W2989385987 @default.
• W4200532016 cites W2990154656 @default.
• W4200532016 cites W2992633709 @default.
• W4200532016 cites W3020890805 @default.
• W4200532016 cites W3027169469 @default.
• W4200532016 cites W3043636716 @default.
• W4200532016 cites W3044098214 @default.
• W4200532016 cites W3087535438 @default.
• W4200532016 cites W3119210053 @default.
• W4200532016 cites W3126487988 @default.
• W4200532016 cites W3160079418 @default.
• W4200532016 cites W3182855926 @default.
• W4200532016 cites W3192389360 @default.
• W4200532016 cites W4213095840 @default.
• W4200532016 cites W4232013301 @default.
• W4200532016 doi "https://doi.org/10.1016/j.tox.2021.153055" @default.
• W4200532016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34864093" @default.
• W4200532016 hasPublicationYear "2022" @default.
• W4200532016 type Work @default.
• W4200532016 citedByCount "20" @default.
• W4200532016 countsByYear W42005320162022 @default.
• W4200532016 countsByYear W42005320162023 @default.
• W4200532016 crossrefType "journal-article" @default.
• W4200532016 hasAuthorship W4200532016A5022270596 @default.
• W4200532016 hasAuthorship W4200532016A5023102000 @default.
• W4200532016 hasAuthorship W4200532016A5023868028 @default.
• W4200532016 hasAuthorship W4200532016A5031499083 @default.
• W4200532016 hasAuthorship W4200532016A5033033828 @default.
• W4200532016 hasAuthorship W4200532016A5034305048 @default.
• W4200532016 hasAuthorship W4200532016A5045490292 @default.
• W4200532016 hasAuthorship W4200532016A5061940416 @default.
• W4200532016 hasAuthorship W4200532016A5066384705 @default.
• W4200532016 hasAuthorship W4200532016A5077388601 @default.
• W4200532016 hasAuthorship W4200532016A5077574174 @default.
• W4200532016 hasAuthorship W4200532016A5085028455 @default.
• W4200532016 hasConcept C126322002 @default.
• W4200532016 hasConcept C134018914 @default.
• W4200532016 hasConcept C185592680 @default.
• W4200532016 hasConcept C190283241 @default.
• W4200532016 hasConcept C2776151105 @default.
• W4200532016 hasConcept C2780159080 @default.
• W4200532016 hasConcept C2781066024 @default.
• W4200532016 hasConcept C31573885 @default.
• W4200532016 hasConcept C55493867 @default.
• W4200532016 hasConcept C63645605 @default.
• W4200532016 hasConcept C71924100 @default.
• W4200532016 hasConceptScore W4200532016C126322002 @default.
• W4200532016 hasConceptScore W4200532016C134018914 @default.
• W4200532016 hasConceptScore W4200532016C185592680 @default.
• W4200532016 hasConceptScore W4200532016C190283241 @default.
• W4200532016 hasConceptScore W4200532016C2776151105 @default.
• W4200532016 hasConceptScore W4200532016C2780159080 @default.
• W4200532016 hasConceptScore W4200532016C2781066024 @default.

• next