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- W4200532078 abstract "Benzene imine (1) ⇌ 1H-azepine (2) isomerization occurs through sequential valence and endo-exo isomerism. Quantum chemical and quasiclassical trajectory (QCT) simulations reveal the coupled reaction pathway - ring-expansion followed by N-inversion to the most stable isomer, exo-1H-azepine (Exo-2). Direct-dynamics produce a mixture of endo- and exo-1H-azepine stereoisomers and govern the endo-1H-azepine (Endo-2) ⇌ exo-1H-azepine (Exo-2) ratio. Exo-2 is computationally identified as the most stable product while Endo-2 is fleetingly stable with a survival time (ST) ∼50 fs. N-Methyl substitution exclusively results in an exo-1-methyl-1H-azepine isomer. F-substitution at the N-site increases the barrier for N-inversion and alters the preference by stabilizing Endo-2. Interestingly, the exo-1-fluoro-1H-azepine (minor product) is formed through bifurcation via non-statistical dynamics. A highly concaved Arrhenius plot for 1a → 2a highlights the influence of heavy-atom tunneling on valence isomerism, particularly at low temperatures. Heavy-atom tunneling also results in a normal N-H(D) secondary KIE above 100 K even though the increase in hybridization from sp2 to sp3 at nitrogen should cause an inverse KIE classically." @default.
- W4200532078 created "2021-12-31" @default.
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- W4200532078 date "2022-01-01" @default.
- W4200532078 modified "2023-10-18" @default.
- W4200532078 title "Stereoelectronic and dynamical effects dictate nitrogen inversion during valence isomerism in benzene imine" @default.
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- W4200532078 doi "https://doi.org/10.1039/d1sc04855d" @default.
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