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• W4200534900 abstract "Biocatalytic alkylation reactions can be performed with high chemo-, regio- and stereoselectivity using S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) and SAM analogs. Currently, however, this methodology is limited in application due to the rather laborious protocols to access SAM analogs. It has recently been shown that halide methyltransferases (HMTs) enable synthesis and recycling of SAM analogs with readily available haloalkanes as starting material. Here we expand this work by using substrate profiling of the anion MT enzyme family to explore promiscuous SAM analog synthesis. Our study shows that anion MTs are in general very promiscuous with respect to the alkyl chain as well as the halide leaving group. Substrate profiling further suggests that promiscuous anion MTs cluster in sequence space. Next to iodoalkanes, cheaper, less toxic, and more available bromoalkanes have been converted and several haloalkanes bearing short alkyl groups, alkyl rings, and functional groups such as alkene, alkyne and aromatic moieties are accepted as substrates. Further, we applied the SAM analogs as electrophiles in enzyme-catalyzed regioselective pyrazole allylation with 3-bromopropene as starting material." @default.
• W4200534900 created "2021-12-31" @default.
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• W4200534900 date "2022-01-05" @default.
• W4200534900 modified "2023-09-29" @default.
• W4200534900 title "Substrate Profiling of Anion Methyltransferases for Promiscuous Synthesis of <i>S</i> ‐Adenosylmethionine Analogs from Haloalkanes" @default.
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• W4200534900 doi "https://doi.org/10.1002/cbic.202100632" @default.
• W4200534900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34927779" @default.
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