Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200534982> ?p ?o ?g. }
- W4200534982 endingPage "261" @default.
- W4200534982 startingPage "261" @default.
- W4200534982 abstract "The concept of hormesis describes a phenomenon of adaptive response to low-dose ionizing radiation (LDIR). Similarly, the concept of mitohormesis states that the adaptive program in mitochondria is activated in response to minor stress effects. The mechanisms of hormesis effects are not clear, but it is assumed that they can be mediated by reactive oxygen species. Here, we studied effects of LDIR on mitochondria in mesenchymal stem cells. We have found that X-ray radiation at a dose of 10 cGy as well as oxidized fragments of cell-free DNA (cfDNA) at a concentration of 50 ng/mL resulted in an increased expression of a large number of genes regulating the function of the mitochondrial respiratory chain complexes in human mesenchymal stem cells (MSC). Several genes remained upregulated within hours after the exposure. Both X-ray radiation and oxidized cfDNA resulted in upregulation of FIS1 and MFN1 genes, which regulated fusion and fission of mitochondria, within 3-24 h after the exposure. Three hours after the exposure, the number of copies of mitochondrial DNA in cells had increased. These findings support the hypothesis that assumes oxidized cell-free DNA as a mediator of MSC response to low doses of radiation." @default.
- W4200534982 created "2021-12-31" @default.
- W4200534982 creator A5012984969 @default.
- W4200534982 creator A5014414692 @default.
- W4200534982 creator A5031560265 @default.
- W4200534982 creator A5041899270 @default.
- W4200534982 creator A5046988480 @default.
- W4200534982 creator A5047149301 @default.
- W4200534982 creator A5054405791 @default.
- W4200534982 creator A5069217525 @default.
- W4200534982 creator A5083951919 @default.
- W4200534982 date "2021-12-27" @default.
- W4200534982 modified "2023-09-27" @default.
- W4200534982 title "Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells" @default.
- W4200534982 cites W1582272383 @default.
- W4200534982 cites W1600038923 @default.
- W4200534982 cites W1969752287 @default.
- W4200534982 cites W2001773716 @default.
- W4200534982 cites W2004129180 @default.
- W4200534982 cites W2014159055 @default.
- W4200534982 cites W2017275974 @default.
- W4200534982 cites W2020179005 @default.
- W4200534982 cites W2021786783 @default.
- W4200534982 cites W2056673369 @default.
- W4200534982 cites W2057495460 @default.
- W4200534982 cites W2066630518 @default.
- W4200534982 cites W2076769172 @default.
- W4200534982 cites W2079436242 @default.
- W4200534982 cites W2085470258 @default.
- W4200534982 cites W2089663038 @default.
- W4200534982 cites W2104336168 @default.
- W4200534982 cites W2109966195 @default.
- W4200534982 cites W2120600243 @default.
- W4200534982 cites W2125916479 @default.
- W4200534982 cites W2127553088 @default.
- W4200534982 cites W2151568543 @default.
- W4200534982 cites W2158236840 @default.
- W4200534982 cites W2159886619 @default.
- W4200534982 cites W2185370759 @default.
- W4200534982 cites W2201588943 @default.
- W4200534982 cites W2277468569 @default.
- W4200534982 cites W2511725062 @default.
- W4200534982 cites W2534298094 @default.
- W4200534982 cites W2537109546 @default.
- W4200534982 cites W2734784015 @default.
- W4200534982 cites W2750097589 @default.
- W4200534982 cites W2792218846 @default.
- W4200534982 cites W2793006112 @default.
- W4200534982 cites W2801874003 @default.
- W4200534982 cites W2808339519 @default.
- W4200534982 cites W2811034983 @default.
- W4200534982 cites W2889320693 @default.
- W4200534982 cites W2895197931 @default.
- W4200534982 cites W2900333403 @default.
- W4200534982 cites W3026100224 @default.
- W4200534982 cites W3086171259 @default.
- W4200534982 cites W3113317088 @default.
- W4200534982 cites W4229633773 @default.
- W4200534982 doi "https://doi.org/10.3390/ijms23010261" @default.
- W4200534982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35008689" @default.
- W4200534982 hasPublicationYear "2021" @default.
- W4200534982 type Work @default.
- W4200534982 citedByCount "4" @default.
- W4200534982 countsByYear W42005349822022 @default.
- W4200534982 countsByYear W42005349822023 @default.
- W4200534982 crossrefType "journal-article" @default.
- W4200534982 hasAuthorship W4200534982A5012984969 @default.
- W4200534982 hasAuthorship W4200534982A5014414692 @default.
- W4200534982 hasAuthorship W4200534982A5031560265 @default.
- W4200534982 hasAuthorship W4200534982A5041899270 @default.
- W4200534982 hasAuthorship W4200534982A5046988480 @default.
- W4200534982 hasAuthorship W4200534982A5047149301 @default.
- W4200534982 hasAuthorship W4200534982A5054405791 @default.
- W4200534982 hasAuthorship W4200534982A5069217525 @default.
- W4200534982 hasAuthorship W4200534982A5083951919 @default.
- W4200534982 hasBestOaLocation W42005349821 @default.
- W4200534982 hasConcept C104317684 @default.
- W4200534982 hasConcept C111337013 @default.
- W4200534982 hasConcept C121332964 @default.
- W4200534982 hasConcept C127561419 @default.
- W4200534982 hasConcept C143425029 @default.
- W4200534982 hasConcept C150194340 @default.
- W4200534982 hasConcept C153911025 @default.
- W4200534982 hasConcept C162317418 @default.
- W4200534982 hasConcept C163950672 @default.
- W4200534982 hasConcept C18231593 @default.
- W4200534982 hasConcept C185544564 @default.
- W4200534982 hasConcept C186256576 @default.
- W4200534982 hasConcept C198826908 @default.
- W4200534982 hasConcept C24586158 @default.
- W4200534982 hasConcept C2776151105 @default.
- W4200534982 hasConcept C2777755479 @default.
- W4200534982 hasConcept C28328180 @default.
- W4200534982 hasConcept C28859421 @default.
- W4200534982 hasConcept C54355233 @default.
- W4200534982 hasConcept C552990157 @default.
- W4200534982 hasConcept C55493867 @default.
- W4200534982 hasConcept C86803240 @default.