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- W4200535887 abstract "Large inter-individual variability in immunological cell composition and function determines immune responses in general and susceptibility of immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes, the pathophysiological mechanisms through which these variations exert their effects are unknown. In this study, we characterize the genetic and non-genetic factors influencing immune responses in patients with type 1 diabetes. We show that age and season affect both immune cell traits and cytokine production upon stimulation. Genetic variants that determine susceptibility to T1D significantly affect T cell composition. Specifically, the CCR5+ regulatory T cells associate with T1D through the CCR region, suggesting a shared genetic regulation. Genome-wide quantitative trait loci (QTL) mapping analysis of immune traits revealed 15 genetic loci that influence immune responses in T1D. Among them, 12 have never been reported in healthy population studies, implying a disease-specific genetic regulation." @default.
- W4200535887 created "2021-12-31" @default.
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- W4200535887 date "2021-12-07" @default.
- W4200535887 modified "2023-09-27" @default.
- W4200535887 title "Genetic and environmental effects on the immune phenotypes in type 1 diabetes" @default.
- W4200535887 doi "https://doi.org/10.1101/2021.12.06.21264056" @default.
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