FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200538861> ?p ?o ?g. }

• W4200538861 endingPage "105163" @default.
• W4200538861 startingPage "105163" @default.
• W4200538861 abstract "The spike protein of SARS-CoV-2 and the host ACE2 receptor plays a vital role in the entry to the cell. Among which the hotspot residue 501 is continuously subjected to positive selection pressure and induces unusual virulence. Keeping in view the importance of the hot spot residue 501, we predicted the potentially emerging structural variants of 501 residue. We analyzed the binding pattern of wild type and mutants (Spike RBD) to the ACE2 receptor by deciphering variations in the amino acids' interaction networks by graph kernels along with evolutionary, network metrics, and energetic information. Our analysis revealed that N501I, N501T, and N501V increase the binding affinity and alter the intra and inter-residue bonding networks. The N501T has shown strong positive selection and fitness in other animals. Docking results and repeated simulations (three times) confirmed the structural stability and tighter binding of these three variants, correlated with the previous results following the global stability trend. Consequently, we reported three variants N501I, N501T, and N501V could worsen the situation further if they emerged. The relations between the viral fitness and binding affinity is a complicated game thus the emergence of high affinity mutations in the SARS-CoV-2 RBD brings up the question of whether or not positive selection favours these mutations or not?" @default.
• W4200538861 created "2021-12-31" @default.
• W4200538861 creator A5007416894 @default.
• W4200538861 creator A5026707096 @default.
• W4200538861 creator A5032222232 @default.
• W4200538861 creator A5042246162 @default.
• W4200538861 creator A5044173924 @default.
• W4200538861 creator A5045550052 @default.
• W4200538861 creator A5046474212 @default.
• W4200538861 creator A5054224961 @default.
• W4200538861 creator A5055852370 @default.
• W4200538861 creator A5062315365 @default.
• W4200538861 creator A5071411811 @default.
• W4200538861 creator A5073826446 @default.
• W4200538861 creator A5076397213 @default.
• W4200538861 creator A5078443786 @default.
• W4200538861 creator A5087292277 @default.
• W4200538861 date "2022-02-01" @default.
• W4200538861 modified "2023-10-11" @default.
• W4200538861 title "Computational modelling of potentially emerging SARS-CoV-2 spike protein RBDs mutations with higher binding affinity towards ACE2: A structural modelling study" @default.
• W4200538861 cites W10914455 @default.
• W4200538861 cites W2029153773 @default.
• W4200538861 cites W2038532826 @default.
• W4200538861 cites W2081231020 @default.
• W4200538861 cites W2089468765 @default.
• W4200538861 cites W2100561975 @default.
• W4200538861 cites W2103325328 @default.
• W4200538861 cites W2132629607 @default.
• W4200538861 cites W2142868265 @default.
• W4200538861 cites W2153983456 @default.
• W4200538861 cites W2216435628 @default.
• W4200538861 cites W2294798173 @default.
• W4200538861 cites W2332712348 @default.
• W4200538861 cites W2498359070 @default.
• W4200538861 cites W2512372054 @default.
• W4200538861 cites W2787724043 @default.
• W4200538861 cites W2883755802 @default.
• W4200538861 cites W2909194930 @default.
• W4200538861 cites W2945403072 @default.
• W4200538861 cites W3001118548 @default.
• W4200538861 cites W3001897055 @default.
• W4200538861 cites W3002893740 @default.
• W4200538861 cites W3003217347 @default.
• W4200538861 cites W3005660249 @default.
• W4200538861 cites W3008827533 @default.
• W4200538861 cites W3009335299 @default.
• W4200538861 cites W3014067025 @default.
• W4200538861 cites W3015190630 @default.
• W4200538861 cites W3038931692 @default.
• W4200538861 cites W3048584818 @default.
• W4200538861 cites W3048714202 @default.
• W4200538861 cites W3080677494 @default.
• W4200538861 cites W3081474723 @default.
• W4200538861 cites W3096912664 @default.
• W4200538861 cites W3113688533 @default.
• W4200538861 cites W3118790515 @default.
• W4200538861 cites W3118874595 @default.
• W4200538861 cites W3121365103 @default.
• W4200538861 cites W3126996424 @default.
• W4200538861 cites W3131287340 @default.
• W4200538861 cites W3134208712 @default.
• W4200538861 cites W3134566701 @default.
• W4200538861 cites W3136193945 @default.
• W4200538861 cites W3137259003 @default.
• W4200538861 cites W3153785976 @default.
• W4200538861 cites W3159596225 @default.
• W4200538861 cites W3160376113 @default.
• W4200538861 cites W3170677418 @default.
• W4200538861 cites W3173632619 @default.
• W4200538861 cites W3175506019 @default.
• W4200538861 cites W3199436157 @default.
• W4200538861 cites W3199850280 @default.
• W4200538861 doi "https://doi.org/10.1016/j.compbiomed.2021.105163" @default.
• W4200538861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34979405" @default.
• W4200538861 hasPublicationYear "2022" @default.
• W4200538861 type Work @default.
• W4200538861 citedByCount "12" @default.
• W4200538861 countsByYear W42005388612022 @default.
• W4200538861 countsByYear W42005388612023 @default.
• W4200538861 crossrefType "journal-article" @default.
• W4200538861 hasAuthorship W4200538861A5007416894 @default.
• W4200538861 hasAuthorship W4200538861A5026707096 @default.
• W4200538861 hasAuthorship W4200538861A5032222232 @default.
• W4200538861 hasAuthorship W4200538861A5042246162 @default.
• W4200538861 hasAuthorship W4200538861A5044173924 @default.
• W4200538861 hasAuthorship W4200538861A5045550052 @default.
• W4200538861 hasAuthorship W4200538861A5046474212 @default.
• W4200538861 hasAuthorship W4200538861A5054224961 @default.
• W4200538861 hasAuthorship W4200538861A5055852370 @default.
• W4200538861 hasAuthorship W4200538861A5062315365 @default.
• W4200538861 hasAuthorship W4200538861A5071411811 @default.
• W4200538861 hasAuthorship W4200538861A5073826446 @default.
• W4200538861 hasAuthorship W4200538861A5076397213 @default.
• W4200538861 hasAuthorship W4200538861A5078443786 @default.
• W4200538861 hasAuthorship W4200538861A5087292277 @default.
• W4200538861 hasBestOaLocation W42005388612 @default.
• W4200538861 hasConcept C104317684 @default.
• W4200538861 hasConcept C143065580 @default.

• next