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• W4200540336 endingPage "737827" @default.
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• W4200540336 abstract "Dyslexia-associated protein KIAA0319, with immunoglobulin-like polycystic kidney disease (PKD) domains, is a dyslexia susceptibility protein. KIAA0319 participates in neuronal migration and is involved in the interaction between neurons and glial fibers. Recent studies found that KIAA0319 acts as a viral receptor via an interaction between its PKD domains with viruses. KIAA0319 mediates viral internalization via a clathrin-dependent pathway involving interaction with adaptor protein 2 (AP2). In the present study, we identified a cDNA encoding a dyslexia-associated KIAA0319-like protein from Marsupenaeus japonicus (designated as MjKIAA0319L). MjKIAA0319L was upregulated in shrimp challenged by white spot syndrome virus (WSSV). After knockdown of MjKIAA0319L using RNA interference, followed by WSSV infection in shrimp, WSSV replication increased and the shrimp survival rate decreased significantly. Further study found that the extracellular domain of MjKIAA0319L expressed in Escherichia coli bound WSSV particles by interacting with the WSSV envelope protein VP28. Fluorescent immunocytochemical analysis showed that MjKIAA0319L was internalized into the cytoplasm of hemocytes during WSSV infection. The intracellular domain of MjKIAA0319L, comprising a YXXΦ motif, interacted with AP2μ, suggesting that MjKIAA0319L binds to WSSV and induces endocytosis in a clathrin-dependent manner. Therefore, MjKIAA0319L recognizes WSSV via its extracellular domain and induces endocytosis of WSSV through its intracellular domain in shrimp. Thus, the MjKIAA0319L-AP2-clathrin pathway is involved in the phagocytosis of WSSV to restrict viral infection in shrimp." @default.
• W4200540336 created "2021-12-31" @default.
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• W4200540336 date "2022-03-01" @default.
• W4200540336 modified "2023-10-13" @default.
• W4200540336 title "The dyslexia-associated KIAA0319-like protein from Marsupenaeus japonicus recognizes white spot syndrome virus and restricts its replication" @default.
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• W4200540336 doi "https://doi.org/10.1016/j.aquaculture.2021.737827" @default.
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