Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200543375> ?p ?o ?g. }
- W4200543375 endingPage "132152" @default.
- W4200543375 startingPage "132152" @default.
- W4200543375 abstract "Methicillin-resistant Staphylococcus aureus (MRSA) is the most common and widespread antibiotic-resistant species. Novel Schiff-bases (2–8) have been synthesized and characterized using FTIR, 1H NMR, 13C NMR and ESI-Mass spectroscopy. An in vitro anti-MRSA study with the ATCC 43300 strain revealed that compounds 2, 4 and 6 inhibited the MRSA strain significantly (MIC 256–512 µg/mL). The molecular docking study against the FabI enzyme from S. aureus indicated that potent compound 6 has significant docking score (-8.756 Kcal/mol) and forms hydrogen bonding and pi-pi stacking with Tyr157 and additional hydrogen bond with Ser197. All the tested derivatives showed lower toxicity with IC50 values >278 µM and none of them were cytotoxic against mammalian Vero cell line." @default.
- W4200543375 created "2021-12-31" @default.
- W4200543375 creator A5001731139 @default.
- W4200543375 creator A5003442864 @default.
- W4200543375 creator A5014034596 @default.
- W4200543375 creator A5064634732 @default.
- W4200543375 creator A5069225405 @default.
- W4200543375 date "2022-03-01" @default.
- W4200543375 modified "2023-10-10" @default.
- W4200543375 title "Synthesis and characterization of new Schiff-bases as Methicillin resistant Staphylococcus aureus (MRSA) inhibitors" @default.
- W4200543375 cites W1878404532 @default.
- W4200543375 cites W1967943545 @default.
- W4200543375 cites W1973953981 @default.
- W4200543375 cites W1979723172 @default.
- W4200543375 cites W1984113256 @default.
- W4200543375 cites W2026923392 @default.
- W4200543375 cites W2030154323 @default.
- W4200543375 cites W2046203973 @default.
- W4200543375 cites W2048892639 @default.
- W4200543375 cites W2049674084 @default.
- W4200543375 cites W2062478950 @default.
- W4200543375 cites W2082126924 @default.
- W4200543375 cites W2083137210 @default.
- W4200543375 cites W2094217997 @default.
- W4200543375 cites W2101680235 @default.
- W4200543375 cites W2112111953 @default.
- W4200543375 cites W2122171231 @default.
- W4200543375 cites W2130462828 @default.
- W4200543375 cites W2144590059 @default.
- W4200543375 cites W2214354012 @default.
- W4200543375 cites W2276443311 @default.
- W4200543375 cites W2318905168 @default.
- W4200543375 cites W2334494402 @default.
- W4200543375 cites W2399838881 @default.
- W4200543375 cites W2462418396 @default.
- W4200543375 cites W2538154912 @default.
- W4200543375 cites W2593476044 @default.
- W4200543375 cites W2754510205 @default.
- W4200543375 cites W2757863523 @default.
- W4200543375 cites W2774988521 @default.
- W4200543375 cites W2795339868 @default.
- W4200543375 cites W2891857145 @default.
- W4200543375 cites W2896564915 @default.
- W4200543375 cites W2910550373 @default.
- W4200543375 cites W2917773096 @default.
- W4200543375 cites W2950699317 @default.
- W4200543375 cites W2980604111 @default.
- W4200543375 cites W2991330881 @default.
- W4200543375 cites W2998763703 @default.
- W4200543375 cites W3003476614 @default.
- W4200543375 cites W3008104356 @default.
- W4200543375 cites W3008952686 @default.
- W4200543375 cites W3009229119 @default.
- W4200543375 cites W3011444460 @default.
- W4200543375 cites W3015943244 @default.
- W4200543375 cites W3034750014 @default.
- W4200543375 cites W3156706849 @default.
- W4200543375 doi "https://doi.org/10.1016/j.molstruc.2021.132152" @default.
- W4200543375 hasPublicationYear "2022" @default.
- W4200543375 type Work @default.
- W4200543375 citedByCount "8" @default.
- W4200543375 countsByYear W42005433752022 @default.
- W4200543375 countsByYear W42005433752023 @default.
- W4200543375 crossrefType "journal-article" @default.
- W4200543375 hasAuthorship W4200543375A5001731139 @default.
- W4200543375 hasAuthorship W4200543375A5003442864 @default.
- W4200543375 hasAuthorship W4200543375A5014034596 @default.
- W4200543375 hasAuthorship W4200543375A5064634732 @default.
- W4200543375 hasAuthorship W4200543375A5069225405 @default.
- W4200543375 hasConcept C112887158 @default.
- W4200543375 hasConcept C159110408 @default.
- W4200543375 hasConcept C176947019 @default.
- W4200543375 hasConcept C178790620 @default.
- W4200543375 hasConcept C181199279 @default.
- W4200543375 hasConcept C185592680 @default.
- W4200543375 hasConcept C202751555 @default.
- W4200543375 hasConcept C2777052132 @default.
- W4200543375 hasConcept C2779489039 @default.
- W4200543375 hasConcept C32909587 @default.
- W4200543375 hasConcept C41685203 @default.
- W4200543375 hasConcept C501593827 @default.
- W4200543375 hasConcept C523546767 @default.
- W4200543375 hasConcept C54355233 @default.
- W4200543375 hasConcept C55493867 @default.
- W4200543375 hasConcept C71240020 @default.
- W4200543375 hasConcept C71924100 @default.
- W4200543375 hasConcept C86803240 @default.
- W4200543375 hasConcept C89138240 @default.
- W4200543375 hasConcept C89423630 @default.
- W4200543375 hasConceptScore W4200543375C112887158 @default.
- W4200543375 hasConceptScore W4200543375C159110408 @default.
- W4200543375 hasConceptScore W4200543375C176947019 @default.
- W4200543375 hasConceptScore W4200543375C178790620 @default.
- W4200543375 hasConceptScore W4200543375C181199279 @default.
- W4200543375 hasConceptScore W4200543375C185592680 @default.
- W4200543375 hasConceptScore W4200543375C202751555 @default.
- W4200543375 hasConceptScore W4200543375C2777052132 @default.
- W4200543375 hasConceptScore W4200543375C2779489039 @default.