Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200546717> ?p ?o ?g. }
- W4200546717 abstract "Rotavirus (RV) is the foremost enteric pathogen associated with severe diarrheal illness in young children (<5years) and animals worldwide. RV primarily infects mature enterocytes in the intestinal epithelium causing villus atrophy, enhanced epithelial cell turnover and apoptosis. Intestinal epithelial cells (IECs) being the first physical barrier against RV infection employs a range of innate immune strategies to counteract RVs invasion, including mucus production, toll-like receptor signaling and cytokine/chemokine production. Conversely, RVs have evolved numerous mechanisms to escape/subvert host immunity, seizing translation machinery of the host for effective replication and transmission. RV cell entry process involve penetration through the outer mucus layer, interaction with cell surface molecules and intestinal microbiota before reaching the IECs. For successful cell attachment and entry, RVs use sialic acid, histo-blood group antigens, heat shock cognate protein 70 and cell-surface integrins as attachment factors and/or (co)-receptors. In this review, a comprehensive summary of the existing knowledge of mechanisms underlying RV-IECs interactions, including the role of gut microbiota, during RV infection is presented. Understanding these mechanisms is imperative for developing efficacious strategies to control RV infections, including development of antiviral therapies and vaccines that target specific immune system antagonists within IECs." @default.
- W4200546717 created "2021-12-31" @default.
- W4200546717 creator A5033829654 @default.
- W4200546717 creator A5037377735 @default.
- W4200546717 creator A5053117840 @default.
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- W4200546717 creator A5084442629 @default.
- W4200546717 creator A5084923732 @default.
- W4200546717 creator A5089681872 @default.
- W4200546717 date "2021-12-22" @default.
- W4200546717 modified "2023-10-13" @default.
- W4200546717 title "Rotavirus Interactions With Host Intestinal Epithelial Cells" @default.
- W4200546717 cites W13919364 @default.
- W4200546717 cites W1488128764 @default.
- W4200546717 cites W148883625 @default.
- W4200546717 cites W1491526770 @default.
- W4200546717 cites W1505123947 @default.
- W4200546717 cites W1511393469 @default.
- W4200546717 cites W1544174173 @default.
- W4200546717 cites W1553466821 @default.
- W4200546717 cites W1607977850 @default.
- W4200546717 cites W1610515357 @default.
- W4200546717 cites W1755734703 @default.
- W4200546717 cites W1841904820 @default.
- W4200546717 cites W1903799742 @default.
- W4200546717 cites W1966103266 @default.
- W4200546717 cites W1966136245 @default.
- W4200546717 cites W1969540615 @default.
- W4200546717 cites W1969622783 @default.
- W4200546717 cites W1973289148 @default.
- W4200546717 cites W1977137815 @default.
- W4200546717 cites W1977362669 @default.
- W4200546717 cites W1977546970 @default.
- W4200546717 cites W1984372001 @default.
- W4200546717 cites W1984443288 @default.
- W4200546717 cites W1985955773 @default.
- W4200546717 cites W1987679698 @default.
- W4200546717 cites W1997477860 @default.
- W4200546717 cites W2002110984 @default.
- W4200546717 cites W2002765243 @default.
- W4200546717 cites W2002895453 @default.
- W4200546717 cites W2006767067 @default.
- W4200546717 cites W2009645460 @default.
- W4200546717 cites W2009690466 @default.
- W4200546717 cites W2010095150 @default.
- W4200546717 cites W2010095476 @default.
- W4200546717 cites W2010848191 @default.
- W4200546717 cites W2011423580 @default.
- W4200546717 cites W2012268278 @default.
- W4200546717 cites W2013202475 @default.
- W4200546717 cites W2015750714 @default.
- W4200546717 cites W2016496481 @default.
- W4200546717 cites W2017161741 @default.
- W4200546717 cites W2020445888 @default.
- W4200546717 cites W2024053493 @default.
- W4200546717 cites W2024375133 @default.
- W4200546717 cites W2025592853 @default.
- W4200546717 cites W2026811557 @default.
- W4200546717 cites W2028776321 @default.
- W4200546717 cites W2033856426 @default.
- W4200546717 cites W2033941331 @default.
- W4200546717 cites W2034974813 @default.
- W4200546717 cites W2035326826 @default.
- W4200546717 cites W2038053000 @default.
- W4200546717 cites W2039737871 @default.
- W4200546717 cites W2041200643 @default.
- W4200546717 cites W2042587442 @default.
- W4200546717 cites W2042810377 @default.
- W4200546717 cites W2047007523 @default.
- W4200546717 cites W2047440121 @default.
- W4200546717 cites W2047915395 @default.
- W4200546717 cites W2047930958 @default.
- W4200546717 cites W2051580617 @default.
- W4200546717 cites W2051587879 @default.
- W4200546717 cites W2053388780 @default.
- W4200546717 cites W2054068279 @default.
- W4200546717 cites W2055463894 @default.
- W4200546717 cites W2055692179 @default.
- W4200546717 cites W2055925640 @default.
- W4200546717 cites W2056592635 @default.
- W4200546717 cites W2056626440 @default.
- W4200546717 cites W2058440842 @default.
- W4200546717 cites W2058530259 @default.
- W4200546717 cites W2062550809 @default.
- W4200546717 cites W2068718360 @default.
- W4200546717 cites W2068824485 @default.
- W4200546717 cites W2072853431 @default.
- W4200546717 cites W2073576658 @default.
- W4200546717 cites W2074782559 @default.
- W4200546717 cites W2079459330 @default.
- W4200546717 cites W2081159398 @default.
- W4200546717 cites W2082788728 @default.
- W4200546717 cites W2084512022 @default.
- W4200546717 cites W2084937356 @default.
- W4200546717 cites W2085882278 @default.
- W4200546717 cites W2093506734 @default.
- W4200546717 cites W2094326163 @default.
- W4200546717 cites W2095255396 @default.
- W4200546717 cites W2095406871 @default.
- W4200546717 cites W2096372976 @default.