Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200547340> ?p ?o ?g. }
- W4200547340 endingPage "121307" @default.
- W4200547340 startingPage "121307" @default.
- W4200547340 abstract "Due to increasing safety and intracellular delivery concerns about hydrophilic polymers in amphiphilic polymer-based nanoparticles (NPs), this study investigates small hydrophilic molecule-stabilized NPs for effective intracellular delivery with multiorganelle targetability and dual responsiveness to acidic pH/glutathione (GSH). In the construction of small hydrophilic molecule-stabilized NP (MSPCL-NP), the A-B-A-type amphiphilic polymer (MSPCL-P) is composed of two short hydrophilic carboxylate-capped disulfide derivatives (A) that replace hydrophilic polymers and assist in providing colloidal stability and preventing antibody (e.g., at least anti-PEG antibody)-mediated specific interactions and complement activation in the plasma and a hydrophobic multiple disulfide-containing poly(ε-caprolactone) block (B) that carries hydrophobic drugs. The carboxylates on the surface of MSPCL-NP target the acidic extratumoral/endolysosomal milieu by sensing and buffering acidic pH values, and the hydrophobic carboxylic acids improve adsorptive endocytosis and effective endosomal escape. Multiple disulfide linkages selectively target cytosolic GSH, resulting in rapid drug release from the destroyed MSPCL-NP via the cleavage of disulfide bonds in MSPCL-P. Doxorubicin (DOX)-loaded NP (DOX@MSPCL-NP) exerts strong effects on killing cells in vitro and inhibits tumor growth in HCT116 xenograft tumor-bearing mice. In conclusion, the multifunctionality and multispatial targetability of MSPCL-NP might effectively overcome various sequential drug delivery hurdles, ranging from blood circulation to drug release. Furthermore, the introduction of small hydrophilic molecules represents a potential strategy to make self-assembled NPs without the use of hydrophilic polymers." @default.
- W4200547340 created "2021-12-31" @default.
- W4200547340 creator A5004295906 @default.
- W4200547340 creator A5020206432 @default.
- W4200547340 creator A5039455078 @default.
- W4200547340 creator A5040861635 @default.
- W4200547340 creator A5041053589 @default.
- W4200547340 creator A5042826784 @default.
- W4200547340 creator A5048899607 @default.
- W4200547340 creator A5079573974 @default.
- W4200547340 creator A5083524882 @default.
- W4200547340 creator A5091417501 @default.
- W4200547340 creator A5091589126 @default.
- W4200547340 date "2022-01-01" @default.
- W4200547340 modified "2023-10-06" @default.
- W4200547340 title "Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability" @default.
- W4200547340 cites W1752114428 @default.
- W4200547340 cites W1912498426 @default.
- W4200547340 cites W1998327691 @default.
- W4200547340 cites W2014928486 @default.
- W4200547340 cites W2043069157 @default.
- W4200547340 cites W2054567646 @default.
- W4200547340 cites W2071750459 @default.
- W4200547340 cites W2100623297 @default.
- W4200547340 cites W2158155063 @default.
- W4200547340 cites W2240896203 @default.
- W4200547340 cites W2259739023 @default.
- W4200547340 cites W2284550715 @default.
- W4200547340 cites W2315302880 @default.
- W4200547340 cites W2529007481 @default.
- W4200547340 cites W2770537485 @default.
- W4200547340 cites W2803390405 @default.
- W4200547340 cites W2941157893 @default.
- W4200547340 cites W2941434812 @default.
- W4200547340 cites W2984395468 @default.
- W4200547340 cites W2992907419 @default.
- W4200547340 cites W3003603323 @default.
- W4200547340 cites W3008373388 @default.
- W4200547340 cites W3018213314 @default.
- W4200547340 cites W3029123196 @default.
- W4200547340 cites W3082800301 @default.
- W4200547340 cites W3083811806 @default.
- W4200547340 cites W3098742359 @default.
- W4200547340 doi "https://doi.org/10.1016/j.biomaterials.2021.121307" @default.
- W4200547340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34894582" @default.
- W4200547340 hasPublicationYear "2022" @default.
- W4200547340 type Work @default.
- W4200547340 citedByCount "5" @default.
- W4200547340 countsByYear W42005473402022 @default.
- W4200547340 countsByYear W42005473402023 @default.
- W4200547340 crossrefType "journal-article" @default.
- W4200547340 hasAuthorship W4200547340A5004295906 @default.
- W4200547340 hasAuthorship W4200547340A5020206432 @default.
- W4200547340 hasAuthorship W4200547340A5039455078 @default.
- W4200547340 hasAuthorship W4200547340A5040861635 @default.
- W4200547340 hasAuthorship W4200547340A5041053589 @default.
- W4200547340 hasAuthorship W4200547340A5042826784 @default.
- W4200547340 hasAuthorship W4200547340A5048899607 @default.
- W4200547340 hasAuthorship W4200547340A5079573974 @default.
- W4200547340 hasAuthorship W4200547340A5083524882 @default.
- W4200547340 hasAuthorship W4200547340A5091417501 @default.
- W4200547340 hasAuthorship W4200547340A5091589126 @default.
- W4200547340 hasConcept C11268172 @default.
- W4200547340 hasConcept C12554922 @default.
- W4200547340 hasConcept C13245373 @default.
- W4200547340 hasConcept C155672457 @default.
- W4200547340 hasConcept C15920480 @default.
- W4200547340 hasConcept C171250308 @default.
- W4200547340 hasConcept C178790620 @default.
- W4200547340 hasConcept C18150654 @default.
- W4200547340 hasConcept C184651966 @default.
- W4200547340 hasConcept C185592680 @default.
- W4200547340 hasConcept C192562407 @default.
- W4200547340 hasConcept C21951064 @default.
- W4200547340 hasConcept C2778074193 @default.
- W4200547340 hasConcept C2779820397 @default.
- W4200547340 hasConcept C521977710 @default.
- W4200547340 hasConcept C67407626 @default.
- W4200547340 hasConcept C86803240 @default.
- W4200547340 hasConceptScore W4200547340C11268172 @default.
- W4200547340 hasConceptScore W4200547340C12554922 @default.
- W4200547340 hasConceptScore W4200547340C13245373 @default.
- W4200547340 hasConceptScore W4200547340C155672457 @default.
- W4200547340 hasConceptScore W4200547340C15920480 @default.
- W4200547340 hasConceptScore W4200547340C171250308 @default.
- W4200547340 hasConceptScore W4200547340C178790620 @default.
- W4200547340 hasConceptScore W4200547340C18150654 @default.
- W4200547340 hasConceptScore W4200547340C184651966 @default.
- W4200547340 hasConceptScore W4200547340C185592680 @default.
- W4200547340 hasConceptScore W4200547340C192562407 @default.
- W4200547340 hasConceptScore W4200547340C21951064 @default.
- W4200547340 hasConceptScore W4200547340C2778074193 @default.
- W4200547340 hasConceptScore W4200547340C2779820397 @default.
- W4200547340 hasConceptScore W4200547340C521977710 @default.
- W4200547340 hasConceptScore W4200547340C67407626 @default.
- W4200547340 hasConceptScore W4200547340C86803240 @default.
- W4200547340 hasLocation W42005473401 @default.
- W4200547340 hasLocation W42005473402 @default.