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- W4200549795 abstract "Proton minibeam radiation therapy (pMBRT) is a novel cancer therapy approach based on a high spatial dose modulation. pMBRT activates distinct radiobiological mechanisms and it has been shown to lead in small animal experiments to a significant increase in normal tissue dose tolerances while maintaining or enhancing tumor control effectiveness as compared with conventional radiotherapy. Although recently proposed, the biological observations collected thus far challenge the classical paradigm in RT and encourage the preparation of phase I clinical trials. La radiothérapie par mini-faisceaux de protons (pMBRT) est une nouvelle approche de thérapie du cancer basée sur une forte modulation spatiale de la dose. La pMBRT active des mécanismes radiobiologiques distincts et il a été démontré dans des expériences sur de petits animaux qu’elle conduit à une augmentation significative des tolérances de dose pour les tissus normaux tout en maintenant ou en améliorant l’efficacité du contrôle des tumeurs par rapport à la radiothérapie conventionnelle. Bien que récemment proposées, les observations biologiques recueillies jusqu’à présent remettent en question le paradigme classique de la RT et encouragent la préparation d’essais cliniques de phase I." @default.
- W4200549795 created "2021-12-31" @default.
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- W4200549795 date "2021-12-20" @default.
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- W4200549795 title "Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors" @default.
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- W4200549795 doi "https://doi.org/10.5802/crbiol.71" @default.
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