Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200550401> ?p ?o ?g. }
- W4200550401 endingPage "174480692110594" @default.
- W4200550401 startingPage "174480692110594" @default.
- W4200550401 abstract "Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic for chronic migraine. Curiously, inhibition of neurokinin receptor 1 (NK1R) failed to alleviate acute migraine attacks in clinical trials, and the neurokinins were consequently abandoned as potential antimigraine candidates. The reason behind this has remained enigmatic.Utilizing immunohistochemistry and semi-quantitative cell counts the expression of neurokinins and their associated receptors was examined in the rat trigeminal ganglion.Immunohistochemistry results revealed SP co-localization in CGRP positive neurons and C-fibres, where it mainly concentrated at boutons. Neurokinin A (NKA) was observed in a population of C-fibres and small neurons where it could co-localize with SP. In contrast, neurokinin B (NKB) did not co-localize with SP and was observed in large/medium sized neurons and Aδ-fibres. All neurokinin receptors (NK1-3R) were found to be expressed in a majority of trigeminal ganglion neurons and A-fibres.The functional release of SP and CGRP in the trigeminovascular system was stimulated with either 60 mM K+ or 100 nM capsaicin and measured with an enzyme-linked immunosorbent assay (ELISA). ELISA results established that SP can be released locally from trigeminovascular system. The released SP was comparatively minor compared to the CGRP release from stimulated dura mater, trigeminal ganglion neurons and fibres. We hypothesize that SP and CGRP signalling pathways may work in tandem to exacerbate painful stimuli in the TGV system." @default.
- W4200550401 created "2021-12-31" @default.
- W4200550401 creator A5036565846 @default.
- W4200550401 creator A5048776295 @default.
- W4200550401 creator A5084413123 @default.
- W4200550401 creator A5085116945 @default.
- W4200550401 creator A5086914270 @default.
- W4200550401 creator A5087844597 @default.
- W4200550401 date "2021-01-01" @default.
- W4200550401 modified "2023-09-27" @default.
- W4200550401 title "Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain" @default.
- W4200550401 cites W1486930410 @default.
- W4200550401 cites W1967854252 @default.
- W4200550401 cites W1968081766 @default.
- W4200550401 cites W1970846628 @default.
- W4200550401 cites W1975097170 @default.
- W4200550401 cites W1976632666 @default.
- W4200550401 cites W1978432165 @default.
- W4200550401 cites W1979307581 @default.
- W4200550401 cites W1984768437 @default.
- W4200550401 cites W1998139699 @default.
- W4200550401 cites W2000976225 @default.
- W4200550401 cites W2022008397 @default.
- W4200550401 cites W2029253166 @default.
- W4200550401 cites W2032443632 @default.
- W4200550401 cites W2032562396 @default.
- W4200550401 cites W2038649996 @default.
- W4200550401 cites W2058991699 @default.
- W4200550401 cites W2065518439 @default.
- W4200550401 cites W2066457807 @default.
- W4200550401 cites W2066524898 @default.
- W4200550401 cites W2068736424 @default.
- W4200550401 cites W2080360524 @default.
- W4200550401 cites W2083516978 @default.
- W4200550401 cites W2089123585 @default.
- W4200550401 cites W2094681881 @default.
- W4200550401 cites W2125072666 @default.
- W4200550401 cites W2130088345 @default.
- W4200550401 cites W2134150167 @default.
- W4200550401 cites W2138814983 @default.
- W4200550401 cites W2209818202 @default.
- W4200550401 cites W2442224165 @default.
- W4200550401 cites W2586533881 @default.
- W4200550401 cites W2751884637 @default.
- W4200550401 cites W2786913845 @default.
- W4200550401 cites W2801341258 @default.
- W4200550401 cites W2894883593 @default.
- W4200550401 cites W2895868360 @default.
- W4200550401 cites W2940808555 @default.
- W4200550401 cites W2954464607 @default.
- W4200550401 cites W2970903952 @default.
- W4200550401 cites W2971348120 @default.
- W4200550401 cites W2981902069 @default.
- W4200550401 cites W2986783054 @default.
- W4200550401 cites W3032898711 @default.
- W4200550401 doi "https://doi.org/10.1177/17448069211059400" @default.
- W4200550401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34898306" @default.
- W4200550401 hasPublicationYear "2021" @default.
- W4200550401 type Work @default.
- W4200550401 citedByCount "15" @default.
- W4200550401 countsByYear W42005504012022 @default.
- W4200550401 countsByYear W42005504012023 @default.
- W4200550401 crossrefType "journal-article" @default.
- W4200550401 hasAuthorship W4200550401A5036565846 @default.
- W4200550401 hasAuthorship W4200550401A5048776295 @default.
- W4200550401 hasAuthorship W4200550401A5084413123 @default.
- W4200550401 hasAuthorship W4200550401A5085116945 @default.
- W4200550401 hasAuthorship W4200550401A5086914270 @default.
- W4200550401 hasAuthorship W4200550401A5087844597 @default.
- W4200550401 hasBestOaLocation W42005504011 @default.
- W4200550401 hasConcept C118303440 @default.
- W4200550401 hasConcept C126322002 @default.
- W4200550401 hasConcept C134018914 @default.
- W4200550401 hasConcept C137130169 @default.
- W4200550401 hasConcept C163170386 @default.
- W4200550401 hasConcept C169760540 @default.
- W4200550401 hasConcept C170493617 @default.
- W4200550401 hasConcept C185592680 @default.
- W4200550401 hasConcept C2776089194 @default.
- W4200550401 hasConcept C2776352249 @default.
- W4200550401 hasConcept C2776533618 @default.
- W4200550401 hasConcept C2777056410 @default.
- W4200550401 hasConcept C2778541695 @default.
- W4200550401 hasConcept C2780051329 @default.
- W4200550401 hasConcept C2781359426 @default.
- W4200550401 hasConcept C2908647359 @default.
- W4200550401 hasConcept C55938493 @default.
- W4200550401 hasConcept C71924100 @default.
- W4200550401 hasConcept C86803240 @default.
- W4200550401 hasConcept C94487597 @default.
- W4200550401 hasConcept C99454951 @default.
- W4200550401 hasConceptScore W4200550401C118303440 @default.
- W4200550401 hasConceptScore W4200550401C126322002 @default.
- W4200550401 hasConceptScore W4200550401C134018914 @default.
- W4200550401 hasConceptScore W4200550401C137130169 @default.
- W4200550401 hasConceptScore W4200550401C163170386 @default.
- W4200550401 hasConceptScore W4200550401C169760540 @default.
- W4200550401 hasConceptScore W4200550401C170493617 @default.