Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200550764> ?p ?o ?g. }
- W4200550764 abstract "Abstract Subclonal heterogeneity and evolution are characteristics of breast cancer that play a fundamental role in tumour development, progression and resistance to current therapies. In this review, we focus on the recent advances in understanding the epigenetic and transcriptomic changes that occur within breast cancer and their importance in terms of cancer development, progression and therapy resistance with a particular focus on alterations at the single-cell level. Furthermore, we highlight the utility of using single-cell tracing and molecular barcoding methodologies in preclinical models to assess disease evolution and response to therapy. We discuss how the integration of single-cell profiling from patient samples can be used in conjunction with results from preclinical models to untangle the complexities of this disease and identify biomarkers of disease progression, including measures of intra-tumour heterogeneity themselves, and how enhancing this understanding has the potential to uncover new targetable vulnerabilities in breast cancer." @default.
- W4200550764 created "2021-12-31" @default.
- W4200550764 creator A5002010072 @default.
- W4200550764 creator A5057324933 @default.
- W4200550764 creator A5060919268 @default.
- W4200550764 creator A5064639228 @default.
- W4200550764 date "2021-12-21" @default.
- W4200550764 modified "2023-10-01" @default.
- W4200550764 title "Subclonal heterogeneity and evolution in breast cancer" @default.
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