FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200552396> ?p ?o ?g. }

• W4200552396 endingPage "e023300" @default.
• W4200552396 startingPage "e023300" @default.
• W4200552396 abstract "Background After renal transplantation, there is a need of immunosuppressive regimens that effectively prevent allograft rejection while minimizing cardiovascular complications. This substudy of the TRITON trial evaluated the cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in renal transplant recipients. Methods and Results Renal transplant recipients were randomized to MSC therapy, infused at weeks 6 and 7 after transplantation, with withdrawal at week 8 of tacrolimus or standard tacrolimus dose. Fifty-four patients (MSC group=27; control group=27) underwent transthoracic echocardiography at weeks 4 and 24 after transplantation and were included in this substudy. Changes in clinical and echocardiographic variables were compared. The MSC group showed a benefit in blood pressure control, assessed by a significant interaction between changes in diastolic blood pressure and the treatment group (P=0.005), and a higher proportion of patients achieving the predefined blood pressure target of <140/90 mm Hg compared with the control group (59.3% versus 29.6%, P=0.03). A significant reduction in left ventricular mass index was observed in the MSC group, whereas there were no changes in the control group (P=0.002). The proportion of patients with left ventricular hypertrophy decreased at 24 weeks in the MSC group (33.3% versus 70.4%, P=0.006), whereas no changes were noted in the control group (63.0% versus 48.1%, P=0.29). Additionally, MSC therapy prevented progressive left ventricular diastolic dysfunction, as demonstrated by changes in mitral deceleration time and tricuspid regurgitant jet velocity. Conclusions MSC strategy is associated with improved blood pressure control, regression of left ventricular hypertrophy, and prevention of progressive diastolic dysfunction at 24 weeks after transplantation. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03398681." @default.
• W4200552396 created "2021-12-31" @default.
• W4200552396 creator A5023500706 @default.
• W4200552396 creator A5035752811 @default.
• W4200552396 creator A5052170046 @default.
• W4200552396 creator A5053011724 @default.
• W4200552396 creator A5055525925 @default.
• W4200552396 creator A5058384202 @default.
• W4200552396 creator A5058410505 @default.
• W4200552396 creator A5060855777 @default.
• W4200552396 date "2021-12-21" @default.
• W4200552396 modified "2023-10-16" @default.
• W4200552396 title "Cardiovascular Effects of Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Therapy With Early Tacrolimus Withdrawal in Renal Transplant Recipients: An Analysis of the Randomized TRITON Study." @default.
• W4200552396 cites W1560618174 @default.
• W4200552396 cites W1972349848 @default.
• W4200552396 cites W1977316721 @default.
• W4200552396 cites W1989398460 @default.
• W4200552396 cites W1994549657 @default.
• W4200552396 cites W1996167459 @default.
• W4200552396 cites W1999291203 @default.
• W4200552396 cites W2000630485 @default.
• W4200552396 cites W2000718582 @default.
• W4200552396 cites W2003190704 @default.
• W4200552396 cites W2008735850 @default.
• W4200552396 cites W2011253818 @default.
• W4200552396 cites W2023105924 @default.
• W4200552396 cites W2042293234 @default.
• W4200552396 cites W2054827086 @default.
• W4200552396 cites W2055110680 @default.
• W4200552396 cites W2061235756 @default.
• W4200552396 cites W2062409460 @default.
• W4200552396 cites W2065676592 @default.
• W4200552396 cites W2072795041 @default.
• W4200552396 cites W2095666785 @default.
• W4200552396 cites W2096463590 @default.
• W4200552396 cites W2101099004 @default.
• W4200552396 cites W2112777549 @default.
• W4200552396 cites W2123821258 @default.
• W4200552396 cites W2124720938 @default.
• W4200552396 cites W2131728483 @default.
• W4200552396 cites W2132072950 @default.
• W4200552396 cites W2136586552 @default.
• W4200552396 cites W2148178029 @default.
• W4200552396 cites W2149285411 @default.
• W4200552396 cites W2151970753 @default.
• W4200552396 cites W2155965977 @default.
• W4200552396 cites W2168283175 @default.
• W4200552396 cites W2187630416 @default.
• W4200552396 cites W2344387729 @default.
• W4200552396 cites W2405472538 @default.
• W4200552396 cites W2471327176 @default.
• W4200552396 cites W2560976156 @default.
• W4200552396 cites W2605115422 @default.
• W4200552396 cites W2607031541 @default.
• W4200552396 cites W2769010773 @default.
• W4200552396 cites W2893436956 @default.
• W4200552396 cites W2904150606 @default.
• W4200552396 cites W2904356389 @default.
• W4200552396 cites W3015500199 @default.
• W4200552396 cites W3084291565 @default.
• W4200552396 cites W3128582350 @default.
• W4200552396 cites W3146940434 @default.
• W4200552396 cites W1973944445 @default.
• W4200552396 doi "https://doi.org/10.1161/jaha.121.023300" @default.
• W4200552396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34913362" @default.
• W4200552396 hasPublicationYear "2021" @default.
• W4200552396 type Work @default.
• W4200552396 citedByCount "2" @default.
• W4200552396 countsByYear W42005523962023 @default.
• W4200552396 crossrefType "journal-article" @default.
• W4200552396 hasAuthorship W4200552396A5023500706 @default.
• W4200552396 hasAuthorship W4200552396A5035752811 @default.
• W4200552396 hasAuthorship W4200552396A5052170046 @default.
• W4200552396 hasAuthorship W4200552396A5053011724 @default.
• W4200552396 hasAuthorship W4200552396A5055525925 @default.
• W4200552396 hasAuthorship W4200552396A5058384202 @default.
• W4200552396 hasAuthorship W4200552396A5058410505 @default.
• W4200552396 hasAuthorship W4200552396A5060855777 @default.
• W4200552396 hasBestOaLocation W42005523961 @default.
• W4200552396 hasConcept C126322002 @default.
• W4200552396 hasConcept C126894567 @default.
• W4200552396 hasConcept C164705383 @default.
• W4200552396 hasConcept C2776002628 @default.
• W4200552396 hasConcept C2780007613 @default.
• W4200552396 hasConcept C2909675724 @default.
• W4200552396 hasConcept C2911091166 @default.
• W4200552396 hasConcept C71924100 @default.
• W4200552396 hasConcept C84393581 @default.
• W4200552396 hasConceptScore W4200552396C126322002 @default.
• W4200552396 hasConceptScore W4200552396C126894567 @default.
• W4200552396 hasConceptScore W4200552396C164705383 @default.
• W4200552396 hasConceptScore W4200552396C2776002628 @default.
• W4200552396 hasConceptScore W4200552396C2780007613 @default.
• W4200552396 hasConceptScore W4200552396C2909675724 @default.
• W4200552396 hasConceptScore W4200552396C2911091166 @default.
• W4200552396 hasConceptScore W4200552396C71924100 @default.
• W4200552396 hasConceptScore W4200552396C84393581 @default.
• W4200552396 hasIssue "24" @default.

• next