FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200559712> ?p ?o ?g. }

• W4200559712 endingPage "114533" @default.
• W4200559712 startingPage "114533" @default.
• W4200559712 abstract "Pneumococcal conjugate vaccines (PCVs) are formed by bioconjugation of a carrier protein to the purified capsular polysaccharide (Ps) from multiple serological strains of Streptococcus pneumoniae. The associated bioconjugation chemistry relies on initial selective modifications to the Ps backbone structure. Among these modifications, removal of a ketal functional group, termed deketalization, is one that is important for pharmaceutical PCV production. Herein, we report a process monitoring investigation into the deketalization of a polysaccharide relevant to PCV process development. We have applied process analytical technology (PAT) for in situ process monitoring to study the deketalization reaction in real time. We find that in situ FTIR spectroscopy elucidates multiple classes of reaction kinetics, one of which correlates strongly with the deketalization reaction of interest. This PAT approach to real time reaction monitoring offers the possibility of improved process monitoring in the pharmaceutical production of PCVs. To our knowledge, this report represents the first PAT investigation into Ps deketalization. Our findings suggest that broader application of PAT to the chemical modifications associated with PCV bioconjugation, as well as other pharmaceutically relevant bioconjugation processes, carries the power to enhance process understanding, control, and efficiency through real time process monitoring." @default.
• W4200559712 created "2021-12-31" @default.
• W4200559712 creator A5004367423 @default.
• W4200559712 creator A5012938007 @default.
• W4200559712 creator A5015978556 @default.
• W4200559712 creator A5016885064 @default.
• W4200559712 creator A5023264481 @default.
• W4200559712 creator A5024479544 @default.
• W4200559712 creator A5031642972 @default.
• W4200559712 creator A5061663827 @default.
• W4200559712 creator A5079876376 @default.
• W4200559712 creator A5083312189 @default.
• W4200559712 date "2022-02-01" @default.
• W4200559712 modified "2023-10-17" @default.
• W4200559712 title "Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology" @default.
• W4200559712 cites W1966917335 @default.
• W4200559712 cites W1973350855 @default.
• W4200559712 cites W1992941103 @default.
• W4200559712 cites W1993225994 @default.
• W4200559712 cites W2006510549 @default.
• W4200559712 cites W2012408570 @default.
• W4200559712 cites W2018365323 @default.
• W4200559712 cites W2021598569 @default.
• W4200559712 cites W2023231572 @default.
• W4200559712 cites W2027263110 @default.
• W4200559712 cites W2033393434 @default.
• W4200559712 cites W2035332286 @default.
• W4200559712 cites W2039406687 @default.
• W4200559712 cites W2057042736 @default.
• W4200559712 cites W2058055035 @default.
• W4200559712 cites W2100458127 @default.
• W4200559712 cites W2119125127 @default.
• W4200559712 cites W2124082242 @default.
• W4200559712 cites W2198715944 @default.
• W4200559712 cites W2204581405 @default.
• W4200559712 cites W2316131222 @default.
• W4200559712 cites W2316265724 @default.
• W4200559712 cites W2320502765 @default.
• W4200559712 cites W2340218746 @default.
• W4200559712 cites W2514169052 @default.
• W4200559712 cites W2955087478 @default.
• W4200559712 cites W2965317979 @default.
• W4200559712 cites W3035854730 @default.
• W4200559712 cites W3089618914 @default.
• W4200559712 cites W3166899167 @default.
• W4200559712 cites W3193997970 @default.
• W4200559712 doi "https://doi.org/10.1016/j.jpba.2021.114533" @default.
• W4200559712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34929570" @default.
• W4200559712 hasPublicationYear "2022" @default.
• W4200559712 type Work @default.
• W4200559712 citedByCount "4" @default.
• W4200559712 countsByYear W42005597122022 @default.
• W4200559712 countsByYear W42005597122023 @default.
• W4200559712 crossrefType "journal-article" @default.
• W4200559712 hasAuthorship W4200559712A5004367423 @default.
• W4200559712 hasAuthorship W4200559712A5012938007 @default.
• W4200559712 hasAuthorship W4200559712A5015978556 @default.
• W4200559712 hasAuthorship W4200559712A5016885064 @default.
• W4200559712 hasAuthorship W4200559712A5023264481 @default.
• W4200559712 hasAuthorship W4200559712A5024479544 @default.
• W4200559712 hasAuthorship W4200559712A5031642972 @default.
• W4200559712 hasAuthorship W4200559712A5061663827 @default.
• W4200559712 hasAuthorship W4200559712A5079876376 @default.
• W4200559712 hasAuthorship W4200559712A5083312189 @default.
• W4200559712 hasConcept C100817775 @default.
• W4200559712 hasConcept C111919701 @default.
• W4200559712 hasConcept C127413603 @default.
• W4200559712 hasConcept C133731056 @default.
• W4200559712 hasConcept C134306372 @default.
• W4200559712 hasConcept C171250308 @default.
• W4200559712 hasConcept C178144697 @default.
• W4200559712 hasConcept C178790620 @default.
• W4200559712 hasConcept C183696295 @default.
• W4200559712 hasConcept C185592680 @default.
• W4200559712 hasConcept C192562407 @default.
• W4200559712 hasConcept C197336794 @default.
• W4200559712 hasConcept C21880701 @default.
• W4200559712 hasConcept C21951064 @default.
• W4200559712 hasConcept C23963754 @default.
• W4200559712 hasConcept C2777822432 @default.
• W4200559712 hasConcept C2781253189 @default.
• W4200559712 hasConcept C2987858997 @default.
• W4200559712 hasConcept C2988729646 @default.
• W4200559712 hasConcept C33923547 @default.
• W4200559712 hasConcept C41008148 @default.
• W4200559712 hasConcept C42360764 @default.
• W4200559712 hasConcept C43617362 @default.
• W4200559712 hasConcept C4916135 @default.
• W4200559712 hasConcept C501593827 @default.
• W4200559712 hasConcept C55493867 @default.
• W4200559712 hasConcept C98045186 @default.
• W4200559712 hasConceptScore W4200559712C100817775 @default.
• W4200559712 hasConceptScore W4200559712C111919701 @default.
• W4200559712 hasConceptScore W4200559712C127413603 @default.
• W4200559712 hasConceptScore W4200559712C133731056 @default.
• W4200559712 hasConceptScore W4200559712C134306372 @default.
• W4200559712 hasConceptScore W4200559712C171250308 @default.
• W4200559712 hasConceptScore W4200559712C178144697 @default.

• next