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• W4200564072 abstract "Abstract We provide a functional characterization of transcription factor NF-κB in protists and provide information about the evolution and diversification of this biologically important protein. We characterized NF-κB in two protists using phylogenetic, cellular, and biochemical techniques. NF-κB of the holozoan Capsaspora owczarzaki ( Co ) has an N-terminal DNA-binding domain and a C-terminal Ankyrin repeat (ANK) domain, and its DNA-binding specificity is more similar to metazoan NF-κB proteins than to Rel proteins. Removal of the ANK domain allows Co -NF-κB to enter the nucleus, bind DNA, and activate transcription. However, C-terminal processing of Co -NF-κB is not induced by IκB kinases in human cells. Overexpressed Co -NF-κB localizes to the cytoplasm in Co cells. Co -NF-κB mRNA and DNA-binding levels differ across three Capsaspora life stages. RNA-sequencing and GO analyses identify possible gene targets of Co -NF-κB. Three NF-κB-like proteins from the choanoflagellate Acanthoeca spectabilis ( As ) contain conserved Rel Homology domain sequences, but lack C-terminal ANK repeats. All three As -NF-κB proteins constitutively enter the nucleus of cells, but differ in their DNA-binding abilities, transcriptional activation activities, and dimerization properties. These results provide a basis for understanding the evolutionary origins of this key transcription factor and could have implications for the origins of regulated immunity in higher taxa." @default.
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• W4200564072 date "2021-12-16" @default.
• W4200564072 modified "2023-10-16" @default.
• W4200564072 title "Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor" @default.
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