Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200565295> ?p ?o ?g. }
- W4200565295 endingPage "13397" @default.
- W4200565295 startingPage "13397" @default.
- W4200565295 abstract "The innate immune system plays a pivotal role in the first line of host defense against infections and is equipped with patterns recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Several classes of PRRS, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs) recognize distinct microbial components and directly activate immune cells. TLRs are transmembrane receptors, while NLRs and RLRs are intracellular molecules. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. The innate immune system also influences pathways involved in cancer immunosurveillance. Natural and synthetic agonists of TLRs, NLRs, or RLRs can trigger cell death in malignant cells, recruit immune cells, such as DCs, CD8+ T cells, and NK cells, into the tumor microenvironment, and are being explored as promising adjuvants in cancer immunotherapies. In this review, we provide a concise overview of TLRs, NLRs, and RLRs: their structure, functions, signaling pathways, and regulation. We also describe various ligands for these receptors and their possible application in treatment of hematopoietic diseases." @default.
- W4200565295 created "2021-12-31" @default.
- W4200565295 creator A5023810390 @default.
- W4200565295 creator A5030366119 @default.
- W4200565295 creator A5031419975 @default.
- W4200565295 date "2021-12-13" @default.
- W4200565295 modified "2023-10-15" @default.
- W4200565295 title "Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases" @default.
- W4200565295 cites W1483162601 @default.
- W4200565295 cites W1508237796 @default.
- W4200565295 cites W1536422556 @default.
- W4200565295 cites W1561041814 @default.
- W4200565295 cites W1598802044 @default.
- W4200565295 cites W1628984902 @default.
- W4200565295 cites W1706972008 @default.
- W4200565295 cites W1750141645 @default.
- W4200565295 cites W1814665366 @default.
- W4200565295 cites W1848603268 @default.
- W4200565295 cites W1964196894 @default.
- W4200565295 cites W1964793822 @default.
- W4200565295 cites W1967953614 @default.
- W4200565295 cites W1969072247 @default.
- W4200565295 cites W1969342260 @default.
- W4200565295 cites W1970436087 @default.
- W4200565295 cites W1971090658 @default.
- W4200565295 cites W1972425824 @default.
- W4200565295 cites W1972776583 @default.
- W4200565295 cites W1978472852 @default.
- W4200565295 cites W1979869941 @default.
- W4200565295 cites W1987376967 @default.
- W4200565295 cites W1987410025 @default.
- W4200565295 cites W1988197452 @default.
- W4200565295 cites W1988299037 @default.
- W4200565295 cites W1989249407 @default.
- W4200565295 cites W1991982546 @default.
- W4200565295 cites W1992680762 @default.
- W4200565295 cites W1995744610 @default.
- W4200565295 cites W1996050664 @default.
- W4200565295 cites W2000572318 @default.
- W4200565295 cites W2000842113 @default.
- W4200565295 cites W2001166572 @default.
- W4200565295 cites W2001590535 @default.
- W4200565295 cites W2001740313 @default.
- W4200565295 cites W2001747259 @default.
- W4200565295 cites W2001757395 @default.
- W4200565295 cites W2009219530 @default.
- W4200565295 cites W2011507014 @default.
- W4200565295 cites W2012005937 @default.
- W4200565295 cites W2013375587 @default.
- W4200565295 cites W2013999310 @default.
- W4200565295 cites W2014960200 @default.
- W4200565295 cites W2015449243 @default.
- W4200565295 cites W2015784912 @default.
- W4200565295 cites W2017515700 @default.
- W4200565295 cites W2018563185 @default.
- W4200565295 cites W2024015921 @default.
- W4200565295 cites W2025355874 @default.
- W4200565295 cites W2025539475 @default.
- W4200565295 cites W2028553476 @default.
- W4200565295 cites W2028575270 @default.
- W4200565295 cites W2030611349 @default.
- W4200565295 cites W2032196593 @default.
- W4200565295 cites W2033023829 @default.
- W4200565295 cites W2034111645 @default.
- W4200565295 cites W2035189746 @default.
- W4200565295 cites W2039461003 @default.
- W4200565295 cites W2041168913 @default.
- W4200565295 cites W2041282580 @default.
- W4200565295 cites W2042433863 @default.
- W4200565295 cites W2042631198 @default.
- W4200565295 cites W2045958044 @default.
- W4200565295 cites W2045969462 @default.
- W4200565295 cites W2046783872 @default.
- W4200565295 cites W2056623600 @default.
- W4200565295 cites W2059395206 @default.
- W4200565295 cites W2060441844 @default.
- W4200565295 cites W2062835892 @default.
- W4200565295 cites W2063310200 @default.
- W4200565295 cites W2064358027 @default.
- W4200565295 cites W2067359484 @default.
- W4200565295 cites W2067436737 @default.
- W4200565295 cites W2067706259 @default.
- W4200565295 cites W2068189492 @default.
- W4200565295 cites W2068914296 @default.
- W4200565295 cites W2068975016 @default.
- W4200565295 cites W2069502810 @default.
- W4200565295 cites W2073743133 @default.
- W4200565295 cites W2076361525 @default.
- W4200565295 cites W2077995361 @default.
- W4200565295 cites W2078666720 @default.
- W4200565295 cites W2078811876 @default.
- W4200565295 cites W2080399344 @default.
- W4200565295 cites W2083522556 @default.
- W4200565295 cites W2084895452 @default.
- W4200565295 cites W2086720218 @default.
- W4200565295 cites W2088164523 @default.
- W4200565295 cites W2089503694 @default.
- W4200565295 cites W2090144201 @default.