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- W4200565500 abstract "In The Lancet HIV, John Santelli and colleagues 1 Santelli JS Chen IS Nabukalu D et al. HIV combination prevention and declining orphanhood among adolescents, Rakai, Uganda, 2001–18: an observational community cohort study. Lancet HIV. 2022; : e32-e41 Google Scholar show that the highly impactful combination of antiretroviral therapy (ART) and medical male circumcision has reduced orphanhood in Rakai, Uganda. Orphanhood declined from 52% in 2001–02 to 23% by 2016–18 (p<0·0001) and double orphanhood from 20% to 3% (p<0·0001). 1 Santelli JS Chen IS Nabukalu D et al. HIV combination prevention and declining orphanhood among adolescents, Rakai, Uganda, 2001–18: an observational community cohort study. Lancet HIV. 2022; : e32-e41 Google Scholar Concurrently, community ART use increased from 11% in 2005–06 to 78% in 2016–18, while the rates of male circumcision increased from 19% to 65%. 1 Santelli JS Chen IS Nabukalu D et al. HIV combination prevention and declining orphanhood among adolescents, Rakai, Uganda, 2001–18: an observational community cohort study. Lancet HIV. 2022; : e32-e41 Google Scholar These data emphasise the synergy of effective treatment and prevention strategies in improving population health outcomes, not only in adults but also in children and adolescents, by reducing orphanhood and HIV transmission risk. HIV combination prevention and declining orphanhood among adolescents, Rakai, Uganda, 2001–18: an observational community cohort studyWidespread availability and uptake of HIV combination prevention was associated with marked reductions in orphanhood among adolescents. Reductions in orphanhood promise improved health and social outcomes for young people. Full-Text PDF" @default.
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- W4200565500 date "2022-01-01" @default.
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- W4200565500 title "Combination HIV prevention reduces orphanhood in Uganda" @default.
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- W4200565500 doi "https://doi.org/10.1016/s2352-3018(21)00296-4" @default.
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