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- W4200565516 startingPage "309" @default.
- W4200565516 abstract "Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis following central nervous system (CNS) injury/diseased state by a specific defence mechanism called reactive astrogliosis. Recent studies have implicated and placed reactive astrogliosis in the centre of pathophysiology of Alzheimer's disease (AD) and other neurodegenerative disorders. The AD biomarker field is evolving rapidly with new findings providing strong evidence which supports the notion that a reactive astrogliosis is an early event in the time course of AD progression which may precede other pathological hallmarks of AD. Clinical/translational in vivo PET and in vitro postmortem brain imaging studies demonstrated 'a first and second wave' of reactive astrogliosis in AD with distinct close-loop relationships with other pathological biomarkers at different stages of the disease. At the end stages, reactive astrocytes are found to be associated, or in proximity, with amyloid plaque and tau pathological deposits in postmortem AD brains. Several new PET-tracers, which are being in pipeline and validated at a very fast pace for mapping and visualising reactive astrogliosis in the brain, will provide further invaluable mechanistic insights into AD and other non-AD dementia pathologies. The complementary roles of microglia and astrocyte activation in AD progression, along with the clinical value of new fluid astrocytes biomarkers in the context of existing biomarkers, are the latest avenue that needs further exploration." @default.
- W4200565516 created "2021-12-31" @default.
- W4200565516 creator A5018824632 @default.
- W4200565516 creator A5031952467 @default.
- W4200565516 creator A5089411086 @default.
- W4200565516 date "2022-01-07" @default.
- W4200565516 modified "2023-10-18" @default.
- W4200565516 title "Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease" @default.
- W4200565516 cites W1496642521 @default.
- W4200565516 cites W1603094194 @default.
- W4200565516 cites W1966720891 @default.
- W4200565516 cites W1972637602 @default.
- W4200565516 cites W1975094715 @default.
- W4200565516 cites W1982235280 @default.
- W4200565516 cites W1983166842 @default.
- W4200565516 cites W1993326575 @default.
- W4200565516 cites W1994640389 @default.
- W4200565516 cites W2000225222 @default.
- W4200565516 cites W2001618696 @default.
- W4200565516 cites W2004356062 @default.
- W4200565516 cites W2007698927 @default.
- W4200565516 cites W2010476270 @default.
- W4200565516 cites W2012601853 @default.
- W4200565516 cites W2014463750 @default.
- W4200565516 cites W2015885252 @default.
- W4200565516 cites W2016000332 @default.
- W4200565516 cites W2018332716 @default.
- W4200565516 cites W2018813802 @default.
- W4200565516 cites W2022127378 @default.
- W4200565516 cites W2025323869 @default.
- W4200565516 cites W2033759470 @default.
- W4200565516 cites W2038274440 @default.
- W4200565516 cites W2042956691 @default.
- W4200565516 cites W2044400894 @default.
- W4200565516 cites W2044699444 @default.
- W4200565516 cites W2048979954 @default.
- W4200565516 cites W2055180596 @default.
- W4200565516 cites W2058815861 @default.
- W4200565516 cites W2065338300 @default.
- W4200565516 cites W2066295524 @default.
- W4200565516 cites W2073656988 @default.
- W4200565516 cites W2085424855 @default.
- W4200565516 cites W2085706434 @default.
- W4200565516 cites W2088448500 @default.
- W4200565516 cites W2103440561 @default.
- W4200565516 cites W2116347741 @default.
- W4200565516 cites W2134205638 @default.
- W4200565516 cites W2141706699 @default.
- W4200565516 cites W2147191089 @default.
- W4200565516 cites W2154353967 @default.
- W4200565516 cites W2154780300 @default.
- W4200565516 cites W2161722802 @default.
- W4200565516 cites W2163175900 @default.
- W4200565516 cites W2167720733 @default.
- W4200565516 cites W2181835826 @default.
- W4200565516 cites W2196268942 @default.
- W4200565516 cites W2214778242 @default.
- W4200565516 cites W2276853091 @default.
- W4200565516 cites W2289895672 @default.
- W4200565516 cites W2309442902 @default.
- W4200565516 cites W2318651009 @default.
- W4200565516 cites W2405226109 @default.
- W4200565516 cites W2497241389 @default.
- W4200565516 cites W2510806376 @default.
- W4200565516 cites W2529597092 @default.
- W4200565516 cites W2572710398 @default.
- W4200565516 cites W2586662902 @default.
- W4200565516 cites W2587701879 @default.
- W4200565516 cites W2595647051 @default.
- W4200565516 cites W2605212461 @default.
- W4200565516 cites W2609176564 @default.
- W4200565516 cites W2621558595 @default.
- W4200565516 cites W2622807556 @default.
- W4200565516 cites W2700330585 @default.
- W4200565516 cites W2738888781 @default.
- W4200565516 cites W2776096008 @default.
- W4200565516 cites W2777525962 @default.
- W4200565516 cites W2786084903 @default.
- W4200565516 cites W2794128068 @default.
- W4200565516 cites W2798054687 @default.
- W4200565516 cites W2801244110 @default.
- W4200565516 cites W2808363189 @default.
- W4200565516 cites W2884930727 @default.
- W4200565516 cites W2887230896 @default.
- W4200565516 cites W2892858870 @default.
- W4200565516 cites W2898537938 @default.
- W4200565516 cites W2903846280 @default.
- W4200565516 cites W2907017802 @default.
- W4200565516 cites W2908417137 @default.
- W4200565516 cites W2911811341 @default.
- W4200565516 cites W2912556930 @default.
- W4200565516 cites W2920279714 @default.
- W4200565516 cites W2943016427 @default.
- W4200565516 cites W2950022516 @default.
- W4200565516 cites W2970440612 @default.
- W4200565516 cites W3015907136 @default.
- W4200565516 cites W3017075749 @default.
- W4200565516 cites W3042129895 @default.