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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200565786> ?p ?o ?g. }

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• W4200565786 abstract "Relaxin is a pleiotropic hormone shown to confer cardioprotection in several preclinical models of cardiac ischemia-reperfusion injury. In the present study, the effects of up-regulating relaxin family peptide receptor 1 (RXFP1) via adeno-associated virus serotype 9 (AAV9) vectors were investigated in a mouse model of myocardial infarction. AAV9-RXFP1 vectors were generated and injected in adult male CD1 mice. Up-regulation of Rxfp1 was confirmed via quantitative polymerase chain reaction, and overexpressing animals showed increased sensitivity to relaxin-induced ventricular inotropic response. Overexpressing animals also demonstrated reduced infarct size and preserved cardiac function 24 hours after ischemia-reperfusion. Up-regulation of RXFP1 via AAV9 vectors has potential therapeutic utility in preventing adverse remodeling after myocardial infarction." @default.
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• W4200565786 date "2022-01-01" @default.
• W4200565786 modified "2023-10-09" @default.
• W4200565786 title "Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction" @default.
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• W4200565786 doi "https://doi.org/10.1016/j.jacbts.2021.10.012" @default.
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