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• W4200568890 abstract "Corrigendum15 September 2021free access Source Data BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α Diego A Rodriguez Diego A Rodriguez Search for more papers by this author Sebastian Zamorano Sebastian Zamorano Search for more papers by this author Fernanda Lisbona Fernanda Lisbona Search for more papers by this author Diego Rojas-Rivera Diego Rojas-Rivera orcid.org/0000-0002-8773-9830 Search for more papers by this author Hery Urra Hery Urra Search for more papers by this author Juan R Cubillos-Ruiz Juan R Cubillos-Ruiz Search for more papers by this author Ricardo Armisen Ricardo Armisen Search for more papers by this author Daniel R Henriquez Daniel R Henriquez orcid.org/0000-0002-1761-1217 Search for more papers by this author Emily H Cheng Emily H Cheng Search for more papers by this author Michal Letek Michal Letek Search for more papers by this author Tomas Vaisar Tomas Vaisar Search for more papers by this author Thergiory Irrazabal Thergiory Irrazabal Search for more papers by this author Christian Gonzalez-Billault Christian Gonzalez-Billault Search for more papers by this author Anthony Letai Anthony Letai orcid.org/0000-0002-1993-9013 Search for more papers by this author Felipe X Pimentel-Muiños Felipe X Pimentel-Muiños Search for more papers by this author Guido Kroemer Guido Kroemer orcid.org/0000-0002-9334-4405 Search for more papers by this author Claudio Hetz Corresponding Author Claudio Hetz [email protected] orcid.org/0000-0003-1120-7966 Search for more papers by this author Diego A Rodriguez Diego A Rodriguez Search for more papers by this author Sebastian Zamorano Sebastian Zamorano Search for more papers by this author Fernanda Lisbona Fernanda Lisbona Search for more papers by this author Diego Rojas-Rivera Diego Rojas-Rivera orcid.org/0000-0002-8773-9830 Search for more papers by this author Hery Urra Hery Urra Search for more papers by this author Juan R Cubillos-Ruiz Juan R Cubillos-Ruiz Search for more papers by this author Ricardo Armisen Ricardo Armisen Search for more papers by this author Daniel R Henriquez Daniel R Henriquez orcid.org/0000-0002-1761-1217 Search for more papers by this author Emily H Cheng Emily H Cheng Search for more papers by this author Michal Letek Michal Letek Search for more papers by this author Tomas Vaisar Tomas Vaisar Search for more papers by this author Thergiory Irrazabal Thergiory Irrazabal Search for more papers by this author Christian Gonzalez-Billault Christian Gonzalez-Billault Search for more papers by this author Anthony Letai Anthony Letai orcid.org/0000-0002-1993-9013 Search for more papers by this author Felipe X Pimentel-Muiños Felipe X Pimentel-Muiños Search for more papers by this author Guido Kroemer Guido Kroemer orcid.org/0000-0002-9334-4405 Search for more papers by this author Claudio Hetz Corresponding Author Claudio Hetz [email protected] orcid.org/0000-0003-1120-7966 Search for more papers by this author Author Information Diego A Rodriguez, Sebastian Zamorano, Fernanda Lisbona, Diego Rojas-Rivera, Hery Urra, Juan R Cubillos-Ruiz, Ricardo Armisen, Daniel R Henriquez, Emily H Cheng, Michal Letek, Tomas Vaisar, Thergiory Irrazabal, Christian Gonzalez-Billault, Anthony Letai, Felipe X Pimentel-Muiños, Guido Kroemer and Claudio Hetz * The EMBO Journal (2021)40:e109146https://doi.org/10.15252/embj.2021109146 This article corrects the following: BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α17 April 2012 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Correction to: The EMBO Journal (2012) 31: 2322–2335. DOI 10.1038/emboj.2012.84 ¦ Published online 17 April 2012 Figure 4A. Original.Source data are available online for this figure. Figure 4A. Corrected. Source data are available online for this figure. The journal was alerted to the claim that the IRE input panels are identical in Figure 1G. Since the IRE input panels show a high degree of similarity, the source data for both panels are published with this notice for the avoidance of doubt. The HSP90 blot looks very similar in Fig 3F and Fig S4A. The authors confirmed that they had stripped and re-probed the original HSP90 blot in Fig 3F and Fig S4A. Specifically, the membrane was probed with antibodies to IRE1, and HSP90, and then re-probed with anti-PERK antibodies. For that reason, HSP90 was presented in both figures because it is the same experiment. In the source data published with this correction, the authors have marked the original data with contrast boxes and arrows to indicate which blots were presented in the figure. The legends have been updated to state that a control originating from one blot is displayed in both figures. The authors acknowledge that they had removed one set of experimental conditions with wild-type parental DKO cells when preparing Fig 4A and state that this does not change the conclusions of the figure. The figure is herewith updated with a demarcating line and source data for the full experiment is published with this notice. All authors agree with this corrigendum. The authors apologize for any confusion caused by these errors. Supporting Information Source Data for Figure 1G (PDF document, 70.4 KB) Source Data for Figure 3F (PDF document, 759.2 KB) Source Data for Figure 4A (PDF document, 591.7 KB) Source Data for Appendix (PDF document, 2.1 MB) Previous ArticleNext Article Read MoreAbout the coverClose modalView large imageVolume 40,Issue 18,15 September 2021This month's cover highlights the article Host autophagy mediates organ wasting and nutrient mobilization for tumor growth by R. Khezri, P. Holland, T. A. Schoborg, T. E. Rusten and colleagues. The majority of late stage cancer patients suffer cancer cachexia with host metabolic reprogramming and muscle wasting. In this study, whole body X-ray micro computed tomography, metabolomics and stable isotope tracing demonstrate that autophagy in host organs drives wasting and nutrient mobilization utilized for tumor growth in a Drosophila model of cachexia-like wasting. Image shows side view 3D-renderings based on m-CT with muscles (green), fat body (blue) and tumor (red) in control (top) or wasted larva (bottom). (Scientific image by Todd Schoborg, University of Wyoming, USA) Volume 40Issue 1815 September 2021In this issue RelatedDetailsLoading ..." @default.
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