Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200568917> ?p ?o ?g. }
- W4200568917 endingPage "13644" @default.
- W4200568917 startingPage "13644" @default.
- W4200568917 abstract "Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease thought to be principally caused by mutations in sarcomeric proteins. Despite extensive genetic analysis, there are no comprehensive molecular frameworks for how single mutations in contractile proteins result in the diverse assortment of cellular, phenotypic, and pathobiological cascades seen in HCM. Molecular profiling and system biology approaches are powerful tools for elucidating, quantifying, and interpreting dynamic signaling pathways and differential macromolecule expression profiles for a wide range of sample types, including cardiomyopathy. Cutting-edge approaches combine high-performance analytical instrumentation (e.g., mass spectrometry) with computational methods (e.g., bioinformatics) to study the comparative activity of biochemical pathways based on relative abundances of functionally linked proteins of interest. Cardiac research is poised to benefit enormously from the application of this toolkit to cardiac tissue models, which recapitulate key aspects of pathogenesis. In this review, we evaluate state-of-the-art mass-spectrometry-based proteomic and phosphoproteomic technologies and their application to in vitro and ex vivo models of HCM for global mapping of macromolecular alterations driving disease progression, emphasizing their potential for defining the components of basic biological systems, the fundamental mechanistic basis of HCM pathogenesis, and treating the ensuing varied clinical outcomes seen among affected patient cohorts." @default.
- W4200568917 created "2021-12-31" @default.
- W4200568917 creator A5076978787 @default.
- W4200568917 creator A5084941297 @default.
- W4200568917 date "2021-12-20" @default.
- W4200568917 modified "2023-09-26" @default.
- W4200568917 title "Mass-Spectrometry-Based Functional Proteomic and Phosphoproteomic Technologies and Their Application for Analyzing Ex Vivo and In Vitro Models of Hypertrophic Cardiomyopathy" @default.
- W4200568917 cites W1942450988 @default.
- W4200568917 cites W1966140207 @default.
- W4200568917 cites W1966552971 @default.
- W4200568917 cites W1973557736 @default.
- W4200568917 cites W1988373211 @default.
- W4200568917 cites W1999215577 @default.
- W4200568917 cites W2005586092 @default.
- W4200568917 cites W2038189266 @default.
- W4200568917 cites W2046110995 @default.
- W4200568917 cites W2056163657 @default.
- W4200568917 cites W2063028213 @default.
- W4200568917 cites W2070050178 @default.
- W4200568917 cites W2086166251 @default.
- W4200568917 cites W2086614100 @default.
- W4200568917 cites W2089547093 @default.
- W4200568917 cites W2091736982 @default.
- W4200568917 cites W2094160006 @default.
- W4200568917 cites W2094512102 @default.
- W4200568917 cites W2119706727 @default.
- W4200568917 cites W2130410032 @default.
- W4200568917 cites W2134406150 @default.
- W4200568917 cites W2144335262 @default.
- W4200568917 cites W2145013717 @default.
- W4200568917 cites W2149847832 @default.
- W4200568917 cites W2167339045 @default.
- W4200568917 cites W2209876008 @default.
- W4200568917 cites W2336169222 @default.
- W4200568917 cites W2347150262 @default.
- W4200568917 cites W2398320673 @default.
- W4200568917 cites W2531146006 @default.
- W4200568917 cites W2556548281 @default.
- W4200568917 cites W2616299533 @default.
- W4200568917 cites W2737012672 @default.
- W4200568917 cites W2738545992 @default.
- W4200568917 cites W2743978568 @default.
- W4200568917 cites W2747721744 @default.
- W4200568917 cites W2756203218 @default.
- W4200568917 cites W2764024258 @default.
- W4200568917 cites W2770578593 @default.
- W4200568917 cites W2775374549 @default.
- W4200568917 cites W2786635794 @default.
- W4200568917 cites W2792087494 @default.
- W4200568917 cites W2796490355 @default.
- W4200568917 cites W2800692959 @default.
- W4200568917 cites W2806733741 @default.
- W4200568917 cites W2810563415 @default.
- W4200568917 cites W2811435008 @default.
- W4200568917 cites W2885004573 @default.
- W4200568917 cites W2889710563 @default.
- W4200568917 cites W2891044412 @default.
- W4200568917 cites W2898190529 @default.
- W4200568917 cites W2898698430 @default.
- W4200568917 cites W2904205646 @default.
- W4200568917 cites W2905412801 @default.
- W4200568917 cites W2910111050 @default.
- W4200568917 cites W2912084914 @default.
- W4200568917 cites W2943154237 @default.
- W4200568917 cites W2944807100 @default.
- W4200568917 cites W2954064471 @default.
- W4200568917 cites W2955366057 @default.
- W4200568917 cites W2968995168 @default.
- W4200568917 cites W2996171578 @default.
- W4200568917 cites W3005901855 @default.
- W4200568917 cites W3006530715 @default.
- W4200568917 cites W3006925753 @default.
- W4200568917 cites W3011609945 @default.
- W4200568917 cites W3014762786 @default.
- W4200568917 cites W3015790912 @default.
- W4200568917 cites W3025060522 @default.
- W4200568917 cites W3028542501 @default.
- W4200568917 cites W3035054819 @default.
- W4200568917 cites W3041584148 @default.
- W4200568917 cites W3041959295 @default.
- W4200568917 cites W3081581547 @default.
- W4200568917 cites W3088010440 @default.
- W4200568917 cites W3088401235 @default.
- W4200568917 cites W3113044156 @default.
- W4200568917 cites W3115099500 @default.
- W4200568917 cites W3116013621 @default.
- W4200568917 cites W3119506213 @default.
- W4200568917 cites W3125204283 @default.
- W4200568917 cites W3127451872 @default.
- W4200568917 cites W3137182980 @default.
- W4200568917 cites W3175894691 @default.
- W4200568917 cites W3195367705 @default.
- W4200568917 cites W4241149889 @default.
- W4200568917 cites W2912261745 @default.
- W4200568917 doi "https://doi.org/10.3390/ijms222413644" @default.
- W4200568917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34948439" @default.
- W4200568917 hasPublicationYear "2021" @default.
- W4200568917 type Work @default.