Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200572571> ?p ?o ?g. }
- W4200572571 endingPage "203760" @default.
- W4200572571 startingPage "203760" @default.
- W4200572571 abstract "Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin springs. During muscle development many sarcomeres assemble in series into long periodic myofibrils that mechanically connect the attached skeleton elements. Thus, ATP-driven myosin forces can power movement of the skeleton. Here we review muscle and myofibril morphogenesis, with a particular focus on their mechanobiology. We describe recent progress on the molecular structure of sarcomeres and their mechanical connections to the skeleton. We discuss current models predicting how tension coordinates the assembly of key sarcomeric components to periodic myofibrils that then further mature during development. This requires transcriptional feedback mechanisms that may help to coordinate myofibril assembly and maturation states with the transcriptional program. To fuel the varying energy demands of muscles we also discuss the close mechanical interactions of myofibrils with mitochondria and nuclei to optimally support powerful or enduring muscle fibers." @default.
- W4200572571 created "2021-12-31" @default.
- W4200572571 creator A5022036519 @default.
- W4200572571 creator A5043761164 @default.
- W4200572571 date "2021-12-01" @default.
- W4200572571 modified "2023-10-14" @default.
- W4200572571 title "Mechanobiology of muscle and myofibril morphogenesis" @default.
- W4200572571 cites W1508178505 @default.
- W4200572571 cites W1543092426 @default.
- W4200572571 cites W1573544812 @default.
- W4200572571 cites W1766184155 @default.
- W4200572571 cites W1775929968 @default.
- W4200572571 cites W1815860013 @default.
- W4200572571 cites W1847176293 @default.
- W4200572571 cites W184748523 @default.
- W4200572571 cites W187216190 @default.
- W4200572571 cites W1906053604 @default.
- W4200572571 cites W1918469567 @default.
- W4200572571 cites W1940751968 @default.
- W4200572571 cites W1949873766 @default.
- W4200572571 cites W1963623972 @default.
- W4200572571 cites W1967399157 @default.
- W4200572571 cites W1969274786 @default.
- W4200572571 cites W1974959278 @default.
- W4200572571 cites W1979159320 @default.
- W4200572571 cites W1979910530 @default.
- W4200572571 cites W1981088192 @default.
- W4200572571 cites W1984447773 @default.
- W4200572571 cites W1989398936 @default.
- W4200572571 cites W1989739302 @default.
- W4200572571 cites W2001577872 @default.
- W4200572571 cites W2001969173 @default.
- W4200572571 cites W2002966962 @default.
- W4200572571 cites W2005178685 @default.
- W4200572571 cites W2005209296 @default.
- W4200572571 cites W2005326389 @default.
- W4200572571 cites W2006778392 @default.
- W4200572571 cites W2007194592 @default.
- W4200572571 cites W2007886911 @default.
- W4200572571 cites W2008985630 @default.
- W4200572571 cites W2009599957 @default.
- W4200572571 cites W2014538072 @default.
- W4200572571 cites W2016761581 @default.
- W4200572571 cites W2019690260 @default.
- W4200572571 cites W2021616768 @default.
- W4200572571 cites W2022960511 @default.
- W4200572571 cites W2023328902 @default.
- W4200572571 cites W2027428052 @default.
- W4200572571 cites W2027687995 @default.
- W4200572571 cites W2030637965 @default.
- W4200572571 cites W2030747779 @default.
- W4200572571 cites W2031383670 @default.
- W4200572571 cites W2031891203 @default.
- W4200572571 cites W2044788731 @default.
- W4200572571 cites W2048305477 @default.
- W4200572571 cites W2051109754 @default.
- W4200572571 cites W2051723944 @default.
- W4200572571 cites W2058314369 @default.
- W4200572571 cites W2058624823 @default.
- W4200572571 cites W2058846791 @default.
- W4200572571 cites W2058912578 @default.
- W4200572571 cites W2066785881 @default.
- W4200572571 cites W2068277549 @default.
- W4200572571 cites W2068573830 @default.
- W4200572571 cites W2069141055 @default.
- W4200572571 cites W2069197226 @default.
- W4200572571 cites W2073944502 @default.
- W4200572571 cites W2074332558 @default.
- W4200572571 cites W2074891449 @default.
- W4200572571 cites W2076143388 @default.
- W4200572571 cites W2077272494 @default.
- W4200572571 cites W2078418281 @default.
- W4200572571 cites W2078663666 @default.
- W4200572571 cites W2079738147 @default.
- W4200572571 cites W2083844714 @default.
- W4200572571 cites W2084675676 @default.
- W4200572571 cites W2085614873 @default.
- W4200572571 cites W2089114409 @default.
- W4200572571 cites W2092036283 @default.
- W4200572571 cites W2094213556 @default.
- W4200572571 cites W2094961514 @default.
- W4200572571 cites W2102021778 @default.
- W4200572571 cites W2102660274 @default.
- W4200572571 cites W2105851009 @default.
- W4200572571 cites W2107634984 @default.
- W4200572571 cites W2110007427 @default.
- W4200572571 cites W2111975407 @default.
- W4200572571 cites W2112590743 @default.
- W4200572571 cites W2117388317 @default.
- W4200572571 cites W2118202513 @default.
- W4200572571 cites W2120102416 @default.
- W4200572571 cites W2120521980 @default.
- W4200572571 cites W2127054999 @default.
- W4200572571 cites W2127085161 @default.
- W4200572571 cites W2127763097 @default.
- W4200572571 cites W2130025116 @default.
- W4200572571 cites W2133085510 @default.
- W4200572571 cites W2134208433 @default.