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- W4200575730 abstract "Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding laeverin, LVRN, when comparing primary tumors of the breast to the tissue of origin, the normal breast. LVRN was also differentially expressed in the brain metastases of patients with metastatic breast cancer. LVRN mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of LVRN in primary tumors of the breast was correlated with overall survival in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. LVRN may be of relevance to initiation, maintenance or progression of cancers of the female breast." @default.
- W4200575730 created "2021-12-31" @default.
- W4200575730 creator A5024900493 @default.
- W4200575730 date "2021-11-09" @default.
- W4200575730 modified "2023-09-28" @default.
- W4200575730 title "Differential expression of laeverin in cancers of the breast." @default.
- W4200575730 doi "https://doi.org/10.31219/osf.io/534tp" @default.
- W4200575730 hasPublicationYear "2021" @default.
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