FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200577029> ?p ?o ?g. }

• W4200577029 endingPage "105010" @default.
• W4200577029 startingPage "105010" @default.
• W4200577029 abstract "A ruptured anterior cruciate ligament (ACL) is often reconstructed with a multiple-strand autograft of a semitendinosus tendon alone or combined with a gracilis tendon. Up to 10% of patients experience graft rupture. This potentially results from excessive local tissue strains under physiological loading which could either result in direct mechanical failure of the graft or induce mechanobiological weakening. Since the original location in the hamstring tendon cannot be traced back from an autograft rupture site, this study explored whether clinical outcome could be further improved by avoiding specific locations or regions of human semitendinosus and/or gracilis tendons in ACL grafts due to potential mechanical or biochemical inferiority. Additionally, it examined numerically which clinically relevant graft configurations experience the lowest strains - and therefore the lowest rupture risk - when loaded with equal force. Remnant full-length gracilis tendons from human ACL reconstructions and full-length semitendinosus- and ipsilateral gracilis tendons of human cadaveric specimens were subjected to a stress-relaxation test. Locations at high risk of mechanical failure were identified using particle tracking to calculate local axial strains. As biochemical properties, the water-, collagen-, glycosaminoglycan- and DNA content per tissue region (representing graft strands) were determined. A viscoelastic lumped parameter model per tendon region was calculated. These models were applied in clinically relevant virtual graft configurations, which were exposed to physiological loading. Configurations that provided lower stiffness - i.e., experiencing higher strains under equal force - were assumed to be at higher risk of failure. Suitability of the gracilis tendon proper to replace semitendinosus muscle-tendon junction strands was examined. Deviations in local axial strains from the globally applied strain were of similar magnitude as the applied strain. Locations of maximum strains were uniformly distributed over tendon lengths. Biochemical compositions varied between tissue regions, but no trends were detected. Viscoelastic parameters were not significantly different between regions within a tendon, although semitendinosus tendons were stiffer than gracilis tendons. Virtual grafts with a full-length semitendinosus tendon alone or combined with a gracilis tendon displayed the lowest strains, whereas strains increased when gracilis tendon strands were tested for their suitability to replace semitendinosus muscle-tendon junction strands. Locations experiencing high local axial strains - which could increase risk of rupture - were present, but no specific region within any of the investigated graft configurations was found to be mechanically or biochemically deviant. Consequently, no specific tendon region could be indicated to provide a higher risk of rupture for mechanical or biochemical reasons. The semitendinosus tendon provided superior stiffness to a graft compared to the gracilis tendon. Therefore, based on our results it would be recommended to use the semitendinosus tendon, and use the gracilis tendon in cases where further reinforcement of the graft is needed to attain the desired length and cross-sectional area. All these data support current clinical standards." @default.
• W4200577029 created "2021-12-31" @default.
• W4200577029 creator A5003371671 @default.
• W4200577029 creator A5012370081 @default.
• W4200577029 creator A5032116167 @default.
• W4200577029 creator A5038386016 @default.
• W4200577029 creator A5061802287 @default.
• W4200577029 creator A5062220922 @default.
• W4200577029 creator A5064240289 @default.
• W4200577029 creator A5081456981 @default.
• W4200577029 creator A5085927001 @default.
• W4200577029 date "2022-02-01" @default.
• W4200577029 modified "2023-09-30" @default.
• W4200577029 title "Local variations in mechanical properties of human hamstring tendon autografts for anterior cruciate ligament reconstruction do not translate to a mechanically inferior strand" @default.
• W4200577029 cites W1488575885 @default.
• W4200577029 cites W1847393090 @default.
• W4200577029 cites W1892508110 @default.
• W4200577029 cites W1949293128 @default.
• W4200577029 cites W1956299394 @default.
• W4200577029 cites W1966271582 @default.
• W4200577029 cites W1971920106 @default.
• W4200577029 cites W1973007077 @default.
• W4200577029 cites W1973557953 @default.
• W4200577029 cites W1994682353 @default.
• W4200577029 cites W1997261415 @default.
• W4200577029 cites W2004747623 @default.
• W4200577029 cites W2009995486 @default.
• W4200577029 cites W2012892026 @default.
• W4200577029 cites W2013014934 @default.
• W4200577029 cites W2014858273 @default.
• W4200577029 cites W2016024704 @default.
• W4200577029 cites W2021154563 @default.
• W4200577029 cites W2023416936 @default.
• W4200577029 cites W2027241072 @default.
• W4200577029 cites W2028724384 @default.
• W4200577029 cites W2032255522 @default.
• W4200577029 cites W2035469813 @default.
• W4200577029 cites W2036188479 @default.
• W4200577029 cites W2036200739 @default.
• W4200577029 cites W2047094916 @default.
• W4200577029 cites W2058827572 @default.
• W4200577029 cites W2061397539 @default.
• W4200577029 cites W2076803296 @default.
• W4200577029 cites W2078132578 @default.
• W4200577029 cites W2078401392 @default.
• W4200577029 cites W2079424409 @default.
• W4200577029 cites W2079455274 @default.
• W4200577029 cites W2082338645 @default.
• W4200577029 cites W2091565731 @default.
• W4200577029 cites W2095812393 @default.
• W4200577029 cites W2098013710 @default.
• W4200577029 cites W2098797628 @default.
• W4200577029 cites W2111587012 @default.
• W4200577029 cites W2113700702 @default.
• W4200577029 cites W2124123252 @default.
• W4200577029 cites W2129771261 @default.
• W4200577029 cites W2134172796 @default.
• W4200577029 cites W2141621619 @default.
• W4200577029 cites W2143814603 @default.
• W4200577029 cites W2157028970 @default.
• W4200577029 cites W2161106045 @default.
• W4200577029 cites W2169750433 @default.
• W4200577029 cites W2276225265 @default.
• W4200577029 cites W2466256173 @default.
• W4200577029 cites W2590423171 @default.
• W4200577029 cites W2594924336 @default.
• W4200577029 cites W2740556019 @default.
• W4200577029 cites W2742627043 @default.
• W4200577029 cites W2751780311 @default.
• W4200577029 cites W2768030996 @default.
• W4200577029 cites W2790319400 @default.
• W4200577029 cites W2796775428 @default.
• W4200577029 cites W2854626589 @default.
• W4200577029 cites W2917177558 @default.
• W4200577029 cites W2944522072 @default.
• W4200577029 cites W3038174430 @default.
• W4200577029 cites W843495100 @default.
• W4200577029 doi "https://doi.org/10.1016/j.jmbbm.2021.105010" @default.
• W4200577029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34896765" @default.
• W4200577029 hasPublicationYear "2022" @default.
• W4200577029 type Work @default.
• W4200577029 citedByCount "2" @default.
• W4200577029 countsByYear W42005770292022 @default.
• W4200577029 countsByYear W42005770292023 @default.
• W4200577029 crossrefType "journal-article" @default.
• W4200577029 hasAuthorship W4200577029A5003371671 @default.
• W4200577029 hasAuthorship W4200577029A5012370081 @default.
• W4200577029 hasAuthorship W4200577029A5032116167 @default.
• W4200577029 hasAuthorship W4200577029A5038386016 @default.
• W4200577029 hasAuthorship W4200577029A5061802287 @default.
• W4200577029 hasAuthorship W4200577029A5062220922 @default.
• W4200577029 hasAuthorship W4200577029A5064240289 @default.
• W4200577029 hasAuthorship W4200577029A5081456981 @default.
• W4200577029 hasAuthorship W4200577029A5085927001 @default.
• W4200577029 hasBestOaLocation W42005770291 @default.
• W4200577029 hasConcept C105702510 @default.
• W4200577029 hasConcept C136229726 @default.
• W4200577029 hasConcept C141071460 @default.

• next