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• W4200580771 abstract "Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091-1.374, p = 5.58 × 10-4), waist circumference (OR: 1.083, 95% CI: 1.027-1.143, p = 0.003), hypertension (OR: 1.028, 95% CI: 1.016-1.039, p = 1.34 × 10-6) and triglycerides (OR: 1.111, 95% CI: 1.060-1.163, p = 9.35 × 10-6) while negative associated with HDL-C (OR: 0.932, 95% CI: 0.885-0.981, p = 0.007) but not FBG (OR: 1.010, 95% CI: 0.986-1.034, p = 1.34). No causal relationships were identified for MetS and its components on depression risk. The present MR analysis strength the evidence that depression is a risk factor for MetS and its components (waist circumference, hypertension, FBG, triglycerides, and HDL-C). Early diagnosis and prevention of depression are crucial in the management of MetS and its components." @default.
• W4200580771 created "2021-12-31" @default.
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• W4200580771 date "2021-12-13" @default.
• W4200580771 modified "2023-10-03" @default.
• W4200580771 title "The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study" @default.
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• W4200580771 cites W2092771645 @default.
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• W4200580771 cites W2106036991 @default.
• W4200580771 cites W2127768736 @default.
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• W4200580771 cites W2153118028 @default.
• W4200580771 cites W2155054485 @default.
• W4200580771 cites W2155533485 @default.
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• W4200580771 cites W2164957626 @default.
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• W4200580771 cites W2761141539 @default.
• W4200580771 cites W2765953779 @default.
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• W4200580771 doi "https://doi.org/10.1038/s41398-021-01759-z" @default.
• W4200580771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34903730" @default.
• W4200580771 hasPublicationYear "2021" @default.
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