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• W4200581306 abstract "Abstract Tandem repeat expansions (TREs) can cause neurological diseases but their impact in schizophrenia is unclear. Here we analyzed genome sequences of adults with schizophrenia and found that they have a higher burden of TREs that are near exons and rare in the general population, compared with non-psychiatric controls. These TREs are disproportionately found at loci known to be associated with schizophrenia from genome-wide association studies, in individuals with clinically-relevant genetic variants at other schizophrenia loci, and in families where multiple individuals have schizophrenia. Our findings support the involvement of genome-wide rare TREs in the polygenic nature of schizophrenia." @default.
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• W4200581306 date "2021-12-21" @default.
• W4200581306 modified "2023-09-29" @default.
• W4200581306 title "Genome-wide tandem repeat expansions contribute to schizophrenia risk" @default.
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• W4200581306 doi "https://doi.org/10.1101/2021.12.17.21267642" @default.
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