Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200587066> ?p ?o ?g. }
- W4200587066 abstract "Abstract Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3-8-cell stage, posing a significant clinical problem. The mechanisms behind this arrest are unclear. Here, we show that the arrested embryos enter a quiescent-like state, marked by cell cycle arrest, the downregulation of ribosomes and histones and downregulation of MYC and p53 activity. Mechanistically, the arrested embryos can be divided into three types. Type I embryos fail to complete the maternal-zygotic transition, and type II/III embryos have erroneously low levels of glycolysis and variable levels of oxidative phosphorylation. Treatment with resveratrol or nicotinamide riboside (NR) can partially rescue the arrested phenotype. The mechanism of reactivation involves the upregulation of SIRT1, and activation of glycolysis and fatty acid oxidation which forces the embryos out of a quiescent state. Overall, our data reveal how human embryo arrest can be overcome by modulating metabolic pathways." @default.
- W4200587066 created "2021-12-31" @default.
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- W4200587066 date "2021-12-21" @default.
- W4200587066 modified "2023-10-14" @default.
- W4200587066 title "Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problems" @default.
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