FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200587777> ?p ?o ?g. }

• W4200587777 endingPage "2040" @default.
• W4200587777 startingPage "2033" @default.
• W4200587777 abstract "Rationale: Outdoor air pollution contributes to asthma development and exacerbations, yet its effects on airway pathology have not been defined in children. Objectives: To explore the possible link between air pollution and airway pathology, we retrospectively examined the relationship between environmental pollutants and pathological changes in bronchial biopsy specimens from children undergoing a clinically indicated bronchoscopy. Methods: Structural and inflammatory changes (basement membrane [BM] thickness, epithelial loss, eosinophils, neutrophils, macrophages, mast cells, and lymphocytes) were quantified in biopsy specimens by using immunohistochemistry. The association between exposure to particulate matter less than 10 μm in aerodynamic diameter (PM10), SO2 and NO2 and biopsy findings was evaluated by using a generalized additive model with Gamma family to allow for overdispersion, adjusted for atmospheric pressure, temperature, humidity, and wheezing. Results: Overall, 98 children were included (age 5.3 ± 2.9 yr; 53 with wheezing/45 without wheezing). BM thickness increased with prolonged exposure to PM10 (rate ratio [RR], 1.29; 95% confidence interval [CI], 1.09-1.52), particularly in children with wheezing. Prolonged exposure to PM10 was also associated with eosinophilic inflammation in children with wheezing (RR, 3.16; 95% CI, 1.35-7.39). Conversely, in children without wheezing, increased PM10 exposure was associated with a reduction of eosinophilic inflammation (RR, 0.12; 95% CI, 0.02-0.6) and neutrophilic inflammation (RR, 0.36; 95% CI, 0.14-0.89). Moreover, NO2 exposure was also linked to reductions in neutrophil infiltration (RR, 0.57; 95% CI, 0.34-0.93) and eosinophil infiltration (RR, 0.33; 95% CI, 0.14-0.77). Conclusions: Different patterns of association were observed in children with wheezing and in children without wheezing. In children without wheezing, exposure to PM10 and NO2 was linked to reduced eosinophilic and neutrophilic inflammation. Conversely, in children with wheezing, prolonged exposure to PM10 was associated with increased BM thickness and eosinophilic inflammation, suggesting that it might contribute to asthma development by promoting airway remodeling and inflammation." @default.
• W4200587777 created "2021-12-31" @default.
• W4200587777 creator A5007369928 @default.
• W4200587777 creator A5013860328 @default.
• W4200587777 creator A5024168074 @default.
• W4200587777 creator A5026035028 @default.
• W4200587777 creator A5028217242 @default.
• W4200587777 creator A5029891019 @default.
• W4200587777 creator A5039268187 @default.
• W4200587777 creator A5052875930 @default.
• W4200587777 creator A5059577678 @default.
• W4200587777 creator A5069038865 @default.
• W4200587777 date "2021-12-01" @default.
• W4200587777 modified "2023-09-29" @default.
• W4200587777 title "Air Pollution Relates to Airway Pathology in Children with Wheezing" @default.
• W4200587777 cites W1515206777 @default.
• W4200587777 cites W1988601441 @default.
• W4200587777 cites W2012814663 @default.
• W4200587777 cites W2014059528 @default.
• W4200587777 cites W2016025974 @default.
• W4200587777 cites W2028844202 @default.
• W4200587777 cites W2042575137 @default.
• W4200587777 cites W2083753594 @default.
• W4200587777 cites W2096879731 @default.
• W4200587777 cites W2107838068 @default.
• W4200587777 cites W2123537216 @default.
• W4200587777 cites W2133437309 @default.
• W4200587777 cites W2141316016 @default.
• W4200587777 cites W2154704691 @default.
• W4200587777 cites W2162407632 @default.
• W4200587777 cites W2169299753 @default.
• W4200587777 cites W2169345320 @default.
• W4200587777 cites W2171508299 @default.
• W4200587777 cites W2523500877 @default.
• W4200587777 cites W2544064672 @default.
• W4200587777 cites W2594110973 @default.
• W4200587777 cites W2737751510 @default.
• W4200587777 cites W2751348284 @default.
• W4200587777 cites W2802354580 @default.
• W4200587777 cites W2806432812 @default.
• W4200587777 cites W2889247572 @default.
• W4200587777 cites W2895313957 @default.
• W4200587777 cites W2896798862 @default.
• W4200587777 cites W2959532034 @default.
• W4200587777 cites W2965403771 @default.
• W4200587777 cites W2997012635 @default.
• W4200587777 cites W3009477821 @default.
• W4200587777 cites W3014923306 @default.
• W4200587777 cites W3041358129 @default.
• W4200587777 cites W3044582272 @default.
• W4200587777 cites W3079068466 @default.
• W4200587777 cites W4210991698 @default.
• W4200587777 doi "https://doi.org/10.1513/annalsats.202010-1321oc" @default.
• W4200587777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34004126" @default.
• W4200587777 hasPublicationYear "2021" @default.
• W4200587777 type Work @default.
• W4200587777 citedByCount "11" @default.
• W4200587777 countsByYear W42005877772021 @default.
• W4200587777 countsByYear W42005877772022 @default.
• W4200587777 countsByYear W42005877772023 @default.
• W4200587777 crossrefType "journal-article" @default.
• W4200587777 hasAuthorship W4200587777A5007369928 @default.
• W4200587777 hasAuthorship W4200587777A5013860328 @default.
• W4200587777 hasAuthorship W4200587777A5024168074 @default.
• W4200587777 hasAuthorship W4200587777A5026035028 @default.
• W4200587777 hasAuthorship W4200587777A5028217242 @default.
• W4200587777 hasAuthorship W4200587777A5029891019 @default.
• W4200587777 hasAuthorship W4200587777A5039268187 @default.
• W4200587777 hasAuthorship W4200587777A5052875930 @default.
• W4200587777 hasAuthorship W4200587777A5059577678 @default.
• W4200587777 hasAuthorship W4200587777A5069038865 @default.
• W4200587777 hasBestOaLocation W42005877771 @default.
• W4200587777 hasConcept C105922876 @default.
• W4200587777 hasConcept C126322002 @default.
• W4200587777 hasConcept C141071460 @default.
• W4200587777 hasConcept C142724271 @default.
• W4200587777 hasConcept C203014093 @default.
• W4200587777 hasConcept C2775934546 @default.
• W4200587777 hasConcept C2776042228 @default.
• W4200587777 hasConcept C2776914184 @default.
• W4200587777 hasConcept C2777037409 @default.
• W4200587777 hasConcept C2779758542 @default.
• W4200587777 hasConcept C44249647 @default.
• W4200587777 hasConcept C71924100 @default.
• W4200587777 hasConcept C82789193 @default.
• W4200587777 hasConcept C90924648 @default.
• W4200587777 hasConceptScore W4200587777C105922876 @default.
• W4200587777 hasConceptScore W4200587777C126322002 @default.
• W4200587777 hasConceptScore W4200587777C141071460 @default.
• W4200587777 hasConceptScore W4200587777C142724271 @default.
• W4200587777 hasConceptScore W4200587777C203014093 @default.
• W4200587777 hasConceptScore W4200587777C2775934546 @default.
• W4200587777 hasConceptScore W4200587777C2776042228 @default.
• W4200587777 hasConceptScore W4200587777C2776914184 @default.
• W4200587777 hasConceptScore W4200587777C2777037409 @default.
• W4200587777 hasConceptScore W4200587777C2779758542 @default.
• W4200587777 hasConceptScore W4200587777C44249647 @default.
• W4200587777 hasConceptScore W4200587777C71924100 @default.

• next