FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200588289> ?p ?o ?g. }

• W4200588289 abstract "Tumors and infectious agents both benefit from an immunosuppressive environment. Cutibacterium acnes (C. acnes) is a bacterium in the normal skin microbiota, which has the ability to survive intracellularly in macrophages and is significantly more common in prostate cancer tissue compared with normal prostate tissue. This study investigated if prostate cancer tissue culture positive for C. acnes has a higher infiltration of regulatory T-cells (Tregs) and if macrophages stimulated with C. acnes induced the expression of immunosuppressive genes that could be linked to an increase of Tregs in prostate cancer. Real-time PCR and enzyme-linked immunosorbent spot assay (ELISA) were used to examine the expression of immunosuppressive genes in human macrophages stimulated in vitro with C. acnes, and associations between the presence of C. acnes and infiltration of Tregs were investigated by statistically analyzing data generated in two previous studies. The in vitro results demonstrated that macrophages stimulated with C. acnes significantly increased their expression of PD-L1, CCL17, and CCL18 mRNA and protein (p <0.05). In the cohort, Tregs in tumor stroma and tumor epithelia were positively associated with the presence of C. acnes (P = 0.0004 and P = 0.046, respectively). Since the macrophages stimulated with C. acnes in vitro increased the expression of immunosuppressive genes, and prostate cancer patients with prostatic C. acnes infection had higher infiltration of Tregs than their noninfected counterparts, we suggest that C. acnes may contribute to an immunosuppressive tumor environment that is vital for prostate cancer progression. IMPORTANCE In an immune suppressive tumor microenvironment constituted by immunosuppressive cells and immunosuppressive mediators, tumors may improve their ability to give rise to a clinically relevant cancer. In the present study, we found that C. acnes might contribute to an immunosuppressive environment by recruiting Tregs and by increasing the expression of immunosuppressive mediators such as PD-L1, CCL17, and CCL18. We believe that our data add support to the hypothesis of a contributing role of C. acnes in prostate cancer development. If established that C. acnes stimulates prostate cancer progression it may open up avenues for targeted prostate cancer treatment." @default.
• W4200588289 created "2021-12-31" @default.
• W4200588289 creator A5019030748 @default.
• W4200588289 creator A5028411564 @default.
• W4200588289 creator A5028566921 @default.
• W4200588289 creator A5039913920 @default.
• W4200588289 creator A5042363365 @default.
• W4200588289 creator A5059133100 @default.
• W4200588289 date "2021-12-22" @default.
• W4200588289 modified "2023-10-02" @default.
• W4200588289 title "Cutibacterium acnes Induces the Expression of Immunosuppressive Genes in Macrophages and is Associated with an Increase of Regulatory T-Cells in Prostate Cancer" @default.
• W4200588289 cites W1496034605 @default.
• W4200588289 cites W1554690759 @default.
• W4200588289 cites W1572810235 @default.
• W4200588289 cites W1589221135 @default.
• W4200588289 cites W1825182601 @default.
• W4200588289 cites W1966104340 @default.
• W4200588289 cites W1970050676 @default.
• W4200588289 cites W2008819902 @default.
• W4200588289 cites W2018545237 @default.
• W4200588289 cites W2022927515 @default.
• W4200588289 cites W2032268859 @default.
• W4200588289 cites W2059724367 @default.
• W4200588289 cites W2068839905 @default.
• W4200588289 cites W2090859076 @default.
• W4200588289 cites W2105064937 @default.
• W4200588289 cites W2107277218 @default.
• W4200588289 cites W2120234965 @default.
• W4200588289 cites W2127182674 @default.
• W4200588289 cites W2136166312 @default.
• W4200588289 cites W2142774522 @default.
• W4200588289 cites W2150678612 @default.
• W4200588289 cites W2155699474 @default.
• W4200588289 cites W2165909284 @default.
• W4200588289 cites W2192080449 @default.
• W4200588289 cites W2218611209 @default.
• W4200588289 cites W2254907138 @default.
• W4200588289 cites W2418323362 @default.
• W4200588289 cites W2471866068 @default.
• W4200588289 cites W2524516638 @default.
• W4200588289 cites W2560367415 @default.
• W4200588289 cites W2598870398 @default.
• W4200588289 cites W2612051769 @default.
• W4200588289 cites W2767512341 @default.
• W4200588289 cites W2892284685 @default.
• W4200588289 cites W2902954996 @default.
• W4200588289 cites W2914738346 @default.
• W4200588289 cites W2933893622 @default.
• W4200588289 cites W2949990498 @default.
• W4200588289 cites W2974291499 @default.
• W4200588289 cites W2984395743 @default.
• W4200588289 cites W3003392716 @default.
• W4200588289 cites W3014004967 @default.
• W4200588289 cites W3081191881 @default.
• W4200588289 cites W3093270998 @default.
• W4200588289 cites W3106021040 @default.
• W4200588289 cites W3198239584 @default.
• W4200588289 cites W4233591248 @default.
• W4200588289 cites W8586986 @default.
• W4200588289 doi "https://doi.org/10.1128/spectrum.01497-21" @default.
• W4200588289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34937192" @default.
• W4200588289 hasPublicationYear "2021" @default.
• W4200588289 type Work @default.
• W4200588289 citedByCount "5" @default.
• W4200588289 countsByYear W42005882892022 @default.
• W4200588289 countsByYear W42005882892023 @default.
• W4200588289 crossrefType "journal-article" @default.
• W4200588289 hasAuthorship W4200588289A5019030748 @default.
• W4200588289 hasAuthorship W4200588289A5028411564 @default.
• W4200588289 hasAuthorship W4200588289A5028566921 @default.
• W4200588289 hasAuthorship W4200588289A5039913920 @default.
• W4200588289 hasAuthorship W4200588289A5042363365 @default.
• W4200588289 hasAuthorship W4200588289A5059133100 @default.
• W4200588289 hasBestOaLocation W42005882893 @default.
• W4200588289 hasConcept C121332964 @default.
• W4200588289 hasConcept C121608353 @default.
• W4200588289 hasConcept C126322002 @default.
• W4200588289 hasConcept C153400128 @default.
• W4200588289 hasConcept C202751555 @default.
• W4200588289 hasConcept C203014093 @default.
• W4200588289 hasConcept C2776107976 @default.
• W4200588289 hasConcept C2776235491 @default.
• W4200588289 hasConcept C2780192828 @default.
• W4200588289 hasConcept C502942594 @default.
• W4200588289 hasConcept C55493867 @default.
• W4200588289 hasConcept C71924100 @default.
• W4200588289 hasConcept C86803240 @default.
• W4200588289 hasConcept C8891405 @default.
• W4200588289 hasConcept C89423630 @default.
• W4200588289 hasConcept C97355855 @default.
• W4200588289 hasConceptScore W4200588289C121332964 @default.
• W4200588289 hasConceptScore W4200588289C121608353 @default.
• W4200588289 hasConceptScore W4200588289C126322002 @default.
• W4200588289 hasConceptScore W4200588289C153400128 @default.
• W4200588289 hasConceptScore W4200588289C202751555 @default.
• W4200588289 hasConceptScore W4200588289C203014093 @default.
• W4200588289 hasConceptScore W4200588289C2776107976 @default.
• W4200588289 hasConceptScore W4200588289C2776235491 @default.
• W4200588289 hasConceptScore W4200588289C2780192828 @default.
• W4200588289 hasConceptScore W4200588289C502942594 @default.

• next