Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200589426> ?p ?o ?g. }
- W4200589426 endingPage "1959" @default.
- W4200589426 startingPage "1959" @default.
- W4200589426 abstract "Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term functional and cognitive impairment and greatly reduces life expectancy. Early genetic studies focused on tracking variations in genome-wide DNA sequences discovered several polymorphisms and novel susceptibility genes associated with AD. However, despite the numerous risk factors already identified, there is still no fully satisfactory explanation for the mechanisms underlying the onset of the disease. Also, as with other complex human diseases, the causes of low heritability are unclear. Epigenetic mechanisms, in which changes in gene expression do not depend on changes in genotype, have attracted considerable attention in recent years and are key to understanding the processes that influence age-related changes and various neurological diseases. With the recent use of massive sequencing techniques, methods for studying epigenome variations in AD have also evolved tremendously, allowing the discovery of differentially expressed disease traits under different conditions and experimental settings. This is important for understanding disease development and for unlocking new potential AD therapies. In this work, we outline the genomic and epigenomic components involved in the initiation and development of AD and identify potentially effective therapeutic targets for disease control." @default.
- W4200589426 created "2021-12-31" @default.
- W4200589426 creator A5025493217 @default.
- W4200589426 creator A5028661543 @default.
- W4200589426 creator A5032838861 @default.
- W4200589426 creator A5038239046 @default.
- W4200589426 date "2021-12-08" @default.
- W4200589426 modified "2023-10-14" @default.
- W4200589426 title "Advances in Genetics and Epigenetic Alterations in Alzheimer’s Disease: A Notion for Therapeutic Treatment" @default.
- W4200589426 cites W1436533512 @default.
- W4200589426 cites W1494932082 @default.
- W4200589426 cites W1495719268 @default.
- W4200589426 cites W1498115555 @default.
- W4200589426 cites W1551233310 @default.
- W4200589426 cites W1579578067 @default.
- W4200589426 cites W1680905070 @default.
- W4200589426 cites W1770378670 @default.
- W4200589426 cites W1851356616 @default.
- W4200589426 cites W1855414735 @default.
- W4200589426 cites W1877630935 @default.
- W4200589426 cites W1918912400 @default.
- W4200589426 cites W1928655587 @default.
- W4200589426 cites W193357416 @default.
- W4200589426 cites W1949288348 @default.
- W4200589426 cites W1961398302 @default.
- W4200589426 cites W1963919142 @default.
- W4200589426 cites W1966831629 @default.
- W4200589426 cites W1967464880 @default.
- W4200589426 cites W1969911647 @default.
- W4200589426 cites W1973577163 @default.
- W4200589426 cites W1973742293 @default.
- W4200589426 cites W1975806945 @default.
- W4200589426 cites W1976773921 @default.
- W4200589426 cites W1983523416 @default.
- W4200589426 cites W1986531971 @default.
- W4200589426 cites W1989141893 @default.
- W4200589426 cites W1991244004 @default.
- W4200589426 cites W1992116441 @default.
- W4200589426 cites W1992594876 @default.
- W4200589426 cites W1993576110 @default.
- W4200589426 cites W1994440387 @default.
- W4200589426 cites W1997820676 @default.
- W4200589426 cites W1997838879 @default.
- W4200589426 cites W1999659629 @default.
- W4200589426 cites W2000356500 @default.
- W4200589426 cites W2004950789 @default.
- W4200589426 cites W2006345816 @default.
- W4200589426 cites W2009111659 @default.
- W4200589426 cites W2009169574 @default.
- W4200589426 cites W2014623973 @default.
- W4200589426 cites W2016066165 @default.
- W4200589426 cites W2018529998 @default.
- W4200589426 cites W2019028138 @default.
- W4200589426 cites W2020089910 @default.
- W4200589426 cites W2021652661 @default.
- W4200589426 cites W2023155523 @default.
- W4200589426 cites W2029248372 @default.
- W4200589426 cites W2038756976 @default.
- W4200589426 cites W2039056262 @default.
- W4200589426 cites W2039607561 @default.
- W4200589426 cites W2043313707 @default.
- W4200589426 cites W2045153164 @default.
- W4200589426 cites W2046234674 @default.
- W4200589426 cites W2048332130 @default.
- W4200589426 cites W2050996088 @default.
- W4200589426 cites W2055995786 @default.
- W4200589426 cites W2057793596 @default.
- W4200589426 cites W2063272219 @default.
- W4200589426 cites W2072124468 @default.
- W4200589426 cites W2074274706 @default.
- W4200589426 cites W2074750860 @default.
- W4200589426 cites W2080612159 @default.
- W4200589426 cites W2081533023 @default.
- W4200589426 cites W2082429191 @default.
- W4200589426 cites W2083617996 @default.
- W4200589426 cites W2085692902 @default.
- W4200589426 cites W2085995080 @default.
- W4200589426 cites W2087243986 @default.
- W4200589426 cites W2088025160 @default.
- W4200589426 cites W2088148170 @default.
- W4200589426 cites W2089740883 @default.
- W4200589426 cites W2090760765 @default.
- W4200589426 cites W2091303550 @default.
- W4200589426 cites W2092010840 @default.
- W4200589426 cites W2096128947 @default.
- W4200589426 cites W2096165693 @default.
- W4200589426 cites W2096223549 @default.
- W4200589426 cites W2097838704 @default.
- W4200589426 cites W2099943275 @default.
- W4200589426 cites W2100978260 @default.
- W4200589426 cites W2107094473 @default.
- W4200589426 cites W2111337273 @default.
- W4200589426 cites W2115779804 @default.
- W4200589426 cites W2117347068 @default.
- W4200589426 cites W2121312696 @default.
- W4200589426 cites W2121349242 @default.
- W4200589426 cites W2121448546 @default.
- W4200589426 cites W2123047934 @default.