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• W4200591282 startingPage "1083" @default.
• W4200591282 abstract "Peroxynitrite (ONOO-) is a potent reactive nitrogen species that plays a role as a critical mediator in liver injury elicited by drugs such as acetaminophen (APAP). At a therapeutic dosage, most APAP is metabolized by liver cells and then excreted in the urine. However, excessive APAP intake can cause an acute production of ONOO-, which induces mitochondrial oxidative stress and necrosis of the liver cells. Therefore, the ONOO- levels in hepatocytes have been considered as an early sign of hepatotoxicity associated with drug overdosage. Herein, a ratiometric theranostic system based on aggregation-induced emission luminogens (AIEgens) for the visualization of ONOO- and reduction of drug-induced hepatotoxicity is developed. The AIEgen ATV-PPB shows a ratiometric fluorescence response from red to green upon cleavage of arylboronic ester moieties by ONOO- with high sensitivity and selectivity. Meanwhile, experiments reveal that ATV-PPB not only acts as a fluorescent probe for ONOO- but also as an intracellular ONOO- scavenger to reduce the hepatotoxicity under overdose APAP treatment." @default.
• W4200591282 created "2021-12-31" @default.
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• W4200591282 date "2022-01-01" @default.
• W4200591282 modified "2023-10-17" @default.
• W4200591282 title "A ratiometric theranostic system for visualization of ONOO⁻ species and reduction of drug-induced hepatotoxicity" @default.
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• W4200591282 doi "https://doi.org/10.1039/d1bm01675j" @default.
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