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- W4200595910 abstract "Abstract Background: To investigate the effects of dexmedetomidine on perioperative potassium and postoperative rehabilitation. Methods: Totally 124 patients scheduled for elective radical resection of gastrointestinal malignant tumor under general anesthesia were included. and randomly assigned to four groups (n=31): groups D 1 , D 2 and D 3 received dexmedetomidine loading dose 1, 1 and 0.5 μg/kg and maintenance dose 0.25, 0.5 and 0.5 μg/kg/h, respectively, group C received normal saline 50 ml/h for 10 min and maintenance dose 10 ml/h. Serum potassium and lactate changes were recorded at 5 min after arteriovenous puncture (T 1 ), 1 h after surgery beginning (T 6 ), surgery ending (T 7 ) and 1 h into the post-anesthesia care unit (PACU) (T 10 ). Serum potassium was examined at 48 h after surgery (T 11 ). Perioperative rehabilitation indicators were recorded. Results: Compared with basal values, serum potassium concentration in groups C, D 1 and D 2 increased significantly at T 11 ( P =0.003, 0.002, and ˂0.001, respectively) and at T 7 ( P =0.008), T 10 ( P =0.015) and T 11 ( P ˂0.001) in group D 3 . Serum potassium at T 11 in group D 2 was significantly lower than group C ( P =0.032). Serum potassium at T 7 in group D 3 was significantly higher than group D 2 ( P =0.036). There were no significant differences in perioperative rehabilitation indicators in all groups. Conclusions: Dexmedetomidine did not decrease perioperative potassium significantly in patients undergoing radical resection of gastrointestinal malignancy, while its loading dose 0.5 μg/kg and maintenance dose 0.5 μg/kg/h can elevate potassium slightly with no adverse effect on perioperative rehabilitation. Trial registration: This study was retrospectively registered on the clinicaltrials.gov website (registration number: NCT04771637)." @default.
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- W4200595910 date "2021-12-29" @default.
- W4200595910 modified "2023-10-16" @default.
- W4200595910 title "Effects of Dexmedetomidine on Perioperative Serum Potassium and Postoperative Rehabilitation of Patients Undergoing Radical Resection of Gastrointestinal Malignancy" @default.
- W4200595910 doi "https://doi.org/10.21203/rs.3.rs-1169113/v1" @default.
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